Mutagenetix > Incidental Mutation

Incidental Mutation 'R5077:Vmn1r19'

401932

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r19

Ensembl Gene

ENSMUSG00000115799

Gene Name

vomeronasal 1 receptor 19

Synonyms

V1rc27

MMRRC Submission

042666-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R5077 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57381449-57382375 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57382026 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 193 (I193T)

Ref Sequence

ENSEMBL: ENSMUSP00000087264 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089830]

AlphaFold

Q8R2C7

Predicted Effect

probably benign
Transcript: ENSMUST00000089830
AA Change: I193T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000087264
Gene: ENSMUSG00000115799
AA Change: I193T

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	6.6e-58	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.7%

Validation Efficiency

93% (51/55)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam34l	A	G	8: 44,080,200 (GRCm39)	V8A	possibly damaging	Het
Agbl4	A	T	4: 111,423,939 (GRCm39)	M322L	probably benign	Het
Ankrd55	A	G	13: 112,492,522 (GRCm39)	K231R	probably benign	Het
Asap1	A	C	15: 63,999,272 (GRCm39)	M534R	probably damaging	Het
B4galnt2	T	A	11: 95,767,140 (GRCm39)		probably benign	Het
Cacna1e	A	T	1: 154,437,475 (GRCm39)		probably null	Het
Cacna1h	T	C	17: 25,594,224 (GRCm39)	I2311M	probably benign	Het
Capn2	G	T	1: 182,300,138 (GRCm39)	D617E	possibly damaging	Het
Catsper1	A	G	19: 5,385,998 (GRCm39)	D77G	probably damaging	Het
Cdc42bpa	A	T	1: 179,922,098 (GRCm39)		probably benign	Het
Cdca8	T	C	4: 124,820,470 (GRCm39)	K109E	probably damaging	Het
Dbx1	A	G	7: 49,283,242 (GRCm39)	S223P	probably damaging	Het
Dlg4	A	G	11: 69,917,852 (GRCm39)	N45S	possibly damaging	Het
Dlgap2	T	G	8: 14,872,691 (GRCm39)	V723G	probably benign	Het
Efl1	C	A	7: 82,307,295 (GRCm39)	Q64K	probably damaging	Het
Eml1	T	A	12: 108,472,871 (GRCm39)		probably benign	Het
Fbxw16	A	G	9: 109,270,117 (GRCm39)		probably null	Het
Gm10800	A	T	2: 98,497,379 (GRCm39)	L80M	probably benign	Het
H4c16	A	G	6: 136,781,113 (GRCm39)	Y89H	probably benign	Het
Insig2	A	T	1: 121,239,964 (GRCm39)	V112E	probably damaging	Het
Kcnip3	A	G	2: 127,307,797 (GRCm39)	S123P	probably damaging	Het
Map3k9	T	C	12: 81,780,851 (GRCm39)		probably null	Het
Myo16	T	C	8: 10,372,658 (GRCm39)	V119A	probably damaging	Het
Naa25	G	A	5: 121,562,639 (GRCm39)	V474M	probably benign	Het
Nckap1	A	T	2: 80,379,277 (GRCm39)	V219E	probably damaging	Het
Niban1	A	G	1: 151,590,274 (GRCm39)	I523V	probably benign	Het
Nrp1	G	T	8: 129,227,154 (GRCm39)		probably null	Het
Nsun4	A	T	4: 115,905,781 (GRCm39)	D58E	probably benign	Het
Obscn	G	T	11: 58,934,883 (GRCm39)	A5249D	probably damaging	Het
Or8k53	A	T	2: 86,177,683 (GRCm39)	H142Q	probably benign	Het
Osmr	A	T	15: 6,873,874 (GRCm39)	Y174*	probably null	Het
Pi4k2a	T	C	19: 42,108,275 (GRCm39)		probably null	Het
Pram1	C	T	17: 33,863,878 (GRCm39)	Q572*	probably null	Het
Prdm5	C	A	6: 65,756,158 (GRCm39)	T25K	probably damaging	Het
Psen1	T	C	12: 83,771,439 (GRCm39)	Y240H	probably damaging	Het
Pygl	C	T	12: 70,248,666 (GRCm39)	G318S	probably benign	Het
Rbck1	A	C	2: 152,160,371 (GRCm39)	M436R	probably benign	Het
Resf1	T	G	6: 149,227,528 (GRCm39)	S191R	probably benign	Het
Rmnd1	T	C	10: 4,377,488 (GRCm39)	N64D	possibly damaging	Het
Rsph4a	A	G	10: 33,784,275 (GRCm39)	D299G	probably damaging	Het
Sema4c	T	C	1: 36,590,812 (GRCm39)	S480G	probably benign	Het
Srp68	T	C	11: 116,136,638 (GRCm39)	D552G	probably damaging	Het
Syde2	G	T	3: 145,707,764 (GRCm39)	A568S	probably damaging	Het
Szrd1	G	T	4: 140,867,092 (GRCm39)		probably null	Het
Szt2	A	T	4: 118,226,813 (GRCm39)		probably null	Het
Tbc1d31	A	G	15: 57,818,797 (GRCm39)	E800G	probably benign	Het
Tmprss11d	C	A	5: 86,457,122 (GRCm39)		probably null	Het
Usp37	A	G	1: 74,480,720 (GRCm39)	V895A	probably damaging	Het
Vmn2r102	T	C	17: 19,897,834 (GRCm39)	V283A	probably benign	Het
Vps13d	C	T	4: 144,814,811 (GRCm39)	G3180D	probably damaging	Het
Xirp2	A	C	2: 67,344,821 (GRCm39)	D2354A	probably benign	Het
Zc3h14	T	A	12: 98,723,465 (GRCm39)		probably null	Het

Other mutations in Vmn1r19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00948:Vmn1r19	APN	6	57,382,247 (GRCm39)	missense	probably benign	0.03
IGL01287:Vmn1r19	APN	6	57,382,179 (GRCm39)	missense	probably damaging	1.00
IGL01516:Vmn1r19	APN	6	57,381,857 (GRCm39)	missense	probably benign	0.03
IGL01895:Vmn1r19	APN	6	57,382,245 (GRCm39)	missense	probably benign	0.02
IGL02676:Vmn1r19	APN	6	57,382,025 (GRCm39)	missense	possibly damaging	0.94
IGL03040:Vmn1r19	APN	6	57,382,347 (GRCm39)	missense	unknown
IGL03087:Vmn1r19	APN	6	57,381,476 (GRCm39)	missense	probably benign	0.01
PIT4802001:Vmn1r19	UTSW	6	57,382,037 (GRCm39)	missense	probably damaging	1.00
R0319:Vmn1r19	UTSW	6	57,381,600 (GRCm39)	missense	possibly damaging	0.93
R1368:Vmn1r19	UTSW	6	57,381,656 (GRCm39)	missense	probably benign	0.01
R1997:Vmn1r19	UTSW	6	57,382,033 (GRCm39)	missense	probably damaging	1.00
R2920:Vmn1r19	UTSW	6	57,381,909 (GRCm39)	missense	probably benign	0.03
R3857:Vmn1r19	UTSW	6	57,382,098 (GRCm39)	missense	possibly damaging	0.68
R4090:Vmn1r19	UTSW	6	57,381,720 (GRCm39)	missense	probably damaging	1.00
R4547:Vmn1r19	UTSW	6	57,381,774 (GRCm39)	missense	possibly damaging	0.56
R4823:Vmn1r19	UTSW	6	57,382,219 (GRCm39)	nonsense	probably null
R4951:Vmn1r19	UTSW	6	57,381,927 (GRCm39)	missense	probably benign	0.36
R5459:Vmn1r19	UTSW	6	57,381,475 (GRCm39)	nonsense	probably null
R5625:Vmn1r19	UTSW	6	57,382,281 (GRCm39)	missense	probably damaging	1.00
R5690:Vmn1r19	UTSW	6	57,381,780 (GRCm39)	missense	probably benign	0.10
R5761:Vmn1r19	UTSW	6	57,382,338 (GRCm39)	missense	unknown
R6124:Vmn1r19	UTSW	6	57,381,602 (GRCm39)	missense	probably benign	0.02
R6373:Vmn1r19	UTSW	6	57,382,317 (GRCm39)	missense	unknown
R6476:Vmn1r19	UTSW	6	57,381,578 (GRCm39)	missense	probably damaging	0.99
R6938:Vmn1r19	UTSW	6	57,381,992 (GRCm39)	missense	possibly damaging	0.94
R7027:Vmn1r19	UTSW	6	57,381,475 (GRCm39)	nonsense	probably null
R7359:Vmn1r19	UTSW	6	57,382,080 (GRCm39)	missense	probably damaging	0.99
R7568:Vmn1r19	UTSW	6	57,381,813 (GRCm39)	missense	possibly damaging	0.69
R7893:Vmn1r19	UTSW	6	57,381,664 (GRCm39)	missense	probably damaging	1.00
R8481:Vmn1r19	UTSW	6	57,381,932 (GRCm39)	missense	probably damaging	0.99
R8487:Vmn1r19	UTSW	6	57,382,166 (GRCm39)	missense	probably benign	0.03
R8812:Vmn1r19	UTSW	6	57,381,436 (GRCm39)	start gained	probably benign
R8907:Vmn1r19	UTSW	6	57,381,991 (GRCm39)	missense	probably benign
R8976:Vmn1r19	UTSW	6	57,381,719 (GRCm39)	missense	probably benign	0.01
R9277:Vmn1r19	UTSW	6	57,382,322 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GGCTATCACAATCAGTCCCAG -3'
(R):5'- ATGAGATGATGAAGTCCACCC -3'

Sequencing Primer
(F):5'- AATCAGTCCCAGTACCTCTTTGTTGG -3'
(R):5'- GATGATGAAGTCCACCCAGTACATG -3'

Posted On

2016-07-22