Incidental Mutation 'R5227:Mov10'
ID 402661
Institutional Source Beutler Lab
Gene Symbol Mov10
Ensembl Gene ENSMUSG00000002227
Gene Name Mov10 RISC complex RNA helicase
Synonyms Mov-10
MMRRC Submission 042800-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.317) question?
Stock # R5227 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 104702152-104725879 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 104709894 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 331 (T331A)
Ref Sequence ENSEMBL: ENSMUSP00000128246 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002297] [ENSMUST00000106774] [ENSMUST00000106775] [ENSMUST00000136148] [ENSMUST00000166979] [ENSMUST00000168015]
AlphaFold P23249
Predicted Effect probably benign
Transcript: ENSMUST00000002297
AA Change: T331A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000002297
Gene: ENSMUSG00000002227
AA Change: T331A

DomainStartEndE-ValueType
low complexity region 297 312 N/A INTRINSIC
low complexity region 338 353 N/A INTRINSIC
AAA 517 699 5.72e-3 SMART
low complexity region 953 970 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106774
SMART Domains Protein: ENSMUSP00000102386
Gene: ENSMUSG00000002227

DomainStartEndE-ValueType
low complexity region 297 312 N/A INTRINSIC
low complexity region 338 353 N/A INTRINSIC
AAA 517 699 5.72e-3 SMART
low complexity region 953 970 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106775
AA Change: T404A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000102387
Gene: ENSMUSG00000002227
AA Change: T404A

DomainStartEndE-ValueType
low complexity region 297 312 N/A INTRINSIC
low complexity region 338 353 N/A INTRINSIC
AAA 517 699 5.72e-3 SMART
low complexity region 953 970 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000136148
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145414
Predicted Effect probably benign
Transcript: ENSMUST00000166979
AA Change: T404A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000126897
Gene: ENSMUSG00000002227
AA Change: T404A

DomainStartEndE-ValueType
low complexity region 61 75 N/A INTRINSIC
low complexity region 370 385 N/A INTRINSIC
low complexity region 411 426 N/A INTRINSIC
AAA 590 772 5.72e-3 SMART
low complexity region 1026 1043 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168015
AA Change: T331A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000128246
Gene: ENSMUSG00000002227
AA Change: T331A

DomainStartEndE-ValueType
low complexity region 297 312 N/A INTRINSIC
low complexity region 338 353 N/A INTRINSIC
AAA 517 699 5.72e-3 SMART
low complexity region 953 970 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196161
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196211
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 99.0%
  • 10x: 98.2%
  • 20x: 97.2%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout is embryonic lethal. Heterozygous knockout leads to reduced dendritic branching of neurons, which affects anxiety- and/or activity-related behavior. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 T C 17: 84,999,249 (GRCm39) L115P probably damaging Het
Adgrb3 A C 1: 25,133,033 (GRCm39) M481R possibly damaging Het
Adgrd1 C A 5: 129,199,647 (GRCm39) N161K probably benign Het
Alx4 T A 2: 93,507,725 (GRCm39) V340D probably damaging Het
Arid1a A G 4: 133,407,716 (GRCm39) S2264P unknown Het
Azi2 A T 9: 117,876,526 (GRCm39) H14L probably damaging Het
Camsap2 A G 1: 136,202,629 (GRCm39) probably benign Het
Ccpg1 T A 9: 72,919,354 (GRCm39) L323* probably null Het
Cpsf1 A T 15: 76,483,148 (GRCm39) I943N probably damaging Het
Crebrf T A 17: 26,978,739 (GRCm39) Y476N probably damaging Het
Defb10 T A 8: 22,351,894 (GRCm39) Y46* probably null Het
Dock3 A G 9: 106,863,269 (GRCm39) L703P probably damaging Het
Ebf2 A T 14: 67,484,518 (GRCm39) I181F probably damaging Het
Eif3e T A 15: 43,114,917 (GRCm39) M420L probably benign Het
Emilin3 T A 2: 160,751,185 (GRCm39) Q188L probably damaging Het
Fbxl4 C T 4: 22,376,840 (GRCm39) T92M probably damaging Het
Fer1l6 C T 15: 58,453,752 (GRCm39) Q687* probably null Het
Fkrp T C 7: 16,544,635 (GRCm39) E409G possibly damaging Het
Fzd9 T C 5: 135,278,460 (GRCm39) D475G probably benign Het
Gabbr1 C T 17: 37,380,958 (GRCm39) T767I possibly damaging Het
Gdf2 G A 14: 33,663,451 (GRCm39) probably null Het
Gpatch1 T C 7: 35,008,776 (GRCm39) N82D probably benign Het
Heg1 T A 16: 33,583,961 (GRCm39) L1256Q probably damaging Het
Ireb2 T A 9: 54,803,885 (GRCm39) probably null Het
Kansl1 T G 11: 104,247,640 (GRCm39) H570P probably benign Het
Kcna10 T G 3: 107,101,744 (GRCm39) M125R probably damaging Het
Lrp1b T G 2: 40,741,805 (GRCm39) I3041L possibly damaging Het
Mbtd1 T C 11: 93,815,474 (GRCm39) F354S possibly damaging Het
Mideas A T 12: 84,199,661 (GRCm39) F1020I probably benign Het
Ms4a8a A T 19: 11,045,780 (GRCm39) S243T probably damaging Het
Ndufa11 T C 17: 57,024,867 (GRCm39) S10P probably benign Het
Olfml3 A G 3: 103,643,737 (GRCm39) Y215H possibly damaging Het
Or2t45 T A 11: 58,669,705 (GRCm39) F251I possibly damaging Het
Or56b2j A G 7: 104,353,529 (GRCm39) I252V possibly damaging Het
Pclo T C 5: 14,763,574 (GRCm39) S4016P probably benign Het
Pcyox1 G C 6: 86,368,726 (GRCm39) A264G probably damaging Het
Pdzrn3 C T 6: 101,130,272 (GRCm39) D515N probably damaging Het
Pnisr A G 4: 21,874,587 (GRCm39) probably benign Het
Prc1 T C 7: 79,962,927 (GRCm39) S574P probably damaging Het
Ranbp3l T A 15: 9,037,186 (GRCm39) V16D probably damaging Het
Rfx1 T C 8: 84,800,687 (GRCm39) V96A probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sfmbt1 T C 14: 30,537,211 (GRCm39) probably null Het
Siglecf T C 7: 43,001,364 (GRCm39) Y111H probably damaging Het
Snx14 G A 9: 88,280,347 (GRCm39) T536I possibly damaging Het
Spindoc A G 19: 7,351,512 (GRCm39) V204A probably benign Het
Sptbn5 A G 2: 119,915,812 (GRCm39) probably benign Het
Swt1 G A 1: 151,278,727 (GRCm39) Q227* probably null Het
Tg A G 15: 66,631,416 (GRCm39) I562V possibly damaging Het
Trip11 T A 12: 101,851,179 (GRCm39) I677F probably damaging Het
Vmn1r49 G A 6: 90,049,753 (GRCm39) T83I probably benign Het
Vmn1r90 T C 7: 14,295,601 (GRCm39) K166E possibly damaging Het
Vmn2r124 T C 17: 18,269,819 (GRCm39) I25T possibly damaging Het
Vps13d A T 4: 144,907,777 (GRCm39) probably null Het
Zfp106 T C 2: 120,354,449 (GRCm39) I170V probably benign Het
Other mutations in Mov10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00498:Mov10 APN 3 104,708,263 (GRCm39) splice site probably benign
IGL01111:Mov10 APN 3 104,708,721 (GRCm39) missense possibly damaging 0.71
IGL01315:Mov10 APN 3 104,703,261 (GRCm39) missense probably damaging 0.98
IGL01463:Mov10 APN 3 104,707,640 (GRCm39) missense probably damaging 1.00
IGL02114:Mov10 APN 3 104,702,634 (GRCm39) unclassified probably benign
IGL02354:Mov10 APN 3 104,711,437 (GRCm39) splice site probably benign
IGL02361:Mov10 APN 3 104,711,437 (GRCm39) splice site probably benign
IGL02692:Mov10 APN 3 104,708,119 (GRCm39) nonsense probably null
IGL03104:Mov10 APN 3 104,704,623 (GRCm39) missense probably damaging 1.00
IGL03121:Mov10 APN 3 104,708,318 (GRCm39) missense probably benign
P0040:Mov10 UTSW 3 104,711,995 (GRCm39) missense probably damaging 1.00
R0025:Mov10 UTSW 3 104,711,919 (GRCm39) missense probably damaging 1.00
R0270:Mov10 UTSW 3 104,702,721 (GRCm39) missense probably benign 0.09
R0747:Mov10 UTSW 3 104,709,812 (GRCm39) missense probably benign 0.41
R1434:Mov10 UTSW 3 104,702,490 (GRCm39) missense probably damaging 1.00
R1482:Mov10 UTSW 3 104,711,862 (GRCm39) missense probably damaging 0.98
R1594:Mov10 UTSW 3 104,702,727 (GRCm39) missense probably damaging 1.00
R1656:Mov10 UTSW 3 104,706,912 (GRCm39) missense probably benign 0.03
R1739:Mov10 UTSW 3 104,707,598 (GRCm39) missense probably damaging 0.98
R1785:Mov10 UTSW 3 104,725,432 (GRCm39) missense possibly damaging 0.73
R1786:Mov10 UTSW 3 104,725,432 (GRCm39) missense possibly damaging 0.73
R1911:Mov10 UTSW 3 104,708,876 (GRCm39) splice site probably benign
R1962:Mov10 UTSW 3 104,704,293 (GRCm39) missense probably damaging 1.00
R1993:Mov10 UTSW 3 104,706,735 (GRCm39) missense probably damaging 1.00
R2095:Mov10 UTSW 3 104,708,847 (GRCm39) missense probably damaging 1.00
R2138:Mov10 UTSW 3 104,711,558 (GRCm39) missense probably benign 0.00
R3107:Mov10 UTSW 3 104,707,040 (GRCm39) missense probably damaging 1.00
R4241:Mov10 UTSW 3 104,704,592 (GRCm39) missense probably benign 0.45
R4280:Mov10 UTSW 3 104,707,095 (GRCm39) missense probably damaging 0.98
R4474:Mov10 UTSW 3 104,725,781 (GRCm39) missense probably damaging 1.00
R5391:Mov10 UTSW 3 104,709,849 (GRCm39) missense probably benign 0.12
R5704:Mov10 UTSW 3 104,706,912 (GRCm39) missense probably benign 0.03
R5819:Mov10 UTSW 3 104,708,828 (GRCm39) missense probably damaging 1.00
R5842:Mov10 UTSW 3 104,706,695 (GRCm39) splice site probably benign
R6059:Mov10 UTSW 3 104,725,266 (GRCm39) utr 3 prime probably benign
R6692:Mov10 UTSW 3 104,725,360 (GRCm39) missense probably damaging 0.97
R7226:Mov10 UTSW 3 104,708,328 (GRCm39) missense probably damaging 1.00
R7426:Mov10 UTSW 3 104,707,368 (GRCm39) splice site probably null
R7633:Mov10 UTSW 3 104,704,381 (GRCm39) missense possibly damaging 0.93
R7637:Mov10 UTSW 3 104,703,201 (GRCm39) missense probably benign 0.26
R7869:Mov10 UTSW 3 104,711,994 (GRCm39) missense probably damaging 1.00
R8684:Mov10 UTSW 3 104,711,690 (GRCm39) missense probably benign
R9008:Mov10 UTSW 3 104,707,332 (GRCm39) missense probably benign 0.09
R9127:Mov10 UTSW 3 104,711,659 (GRCm39) nonsense probably null
R9559:Mov10 UTSW 3 104,708,277 (GRCm39) missense
R9587:Mov10 UTSW 3 104,711,899 (GRCm39) missense probably benign 0.11
R9602:Mov10 UTSW 3 104,708,284 (GRCm39) missense probably benign 0.18
R9606:Mov10 UTSW 3 104,707,664 (GRCm39) missense probably benign 0.00
R9708:Mov10 UTSW 3 104,704,613 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- CAGGTCTGAGTTCTAACCTCCAG -3'
(R):5'- CCAAAGGAGGTTGCTGAGATC -3'

Sequencing Primer
(F):5'- GGGTGAGCAGCCTGGGATTC -3'
(R):5'- TCAAGTAAGTGGCAACCCTTGTG -3'
Posted On 2016-07-22