Incidental Mutation 'R5282:Tstd2'
ID 402809
Institutional Source Beutler Lab
Gene Symbol Tstd2
Ensembl Gene ENSMUSG00000035495
Gene Name thiosulfate sulfurtransferase (rhodanese)-like domain containing 2
Synonyms
MMRRC Submission 042867-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.156) question?
Stock # R5282 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 46114746-46138694 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 46120461 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 313 (Y313C)
Ref Sequence ENSEMBL: ENSMUSP00000103401 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107770] [ENSMUST00000107772] [ENSMUST00000107773]
AlphaFold Q3U269
Predicted Effect probably damaging
Transcript: ENSMUST00000107770
AA Change: Y313C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103399
Gene: ENSMUSG00000035495
AA Change: Y313C

DomainStartEndE-ValueType
low complexity region 44 64 N/A INTRINSIC
RHOD 290 392 2.25e-11 SMART
Pfam:Rhodanese_C 396 459 2.4e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000107772
AA Change: Y313C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000103401
Gene: ENSMUSG00000035495
AA Change: Y313C

DomainStartEndE-ValueType
low complexity region 44 64 N/A INTRINSIC
RHOD 290 392 2.25e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107773
SMART Domains Protein: ENSMUSP00000103402
Gene: ENSMUSG00000028328

DomainStartEndE-ValueType
Pfam:Tropomodulin 3 143 6.3e-64 PFAM
PDB:1IO0|A 160 344 1e-115 PDB
SCOP:d1a4ya_ 181 312 3e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157444
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160008
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 96.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700102P08Rik T A 9: 108,270,439 (GRCm39) M1K probably null Het
2810021J22Rik T C 11: 58,771,166 (GRCm39) L216S possibly damaging Het
4933405O20Rik G A 7: 50,249,220 (GRCm39) E85K possibly damaging Het
Agrn A G 4: 156,257,492 (GRCm39) F1153L probably damaging Het
Cbx8 A G 11: 118,929,742 (GRCm39) S284P probably damaging Het
Cep128 A G 12: 91,305,893 (GRCm39) L170P probably damaging Het
Cyp4f14 T A 17: 33,126,959 (GRCm39) T324S probably damaging Het
Daw1 G T 1: 83,170,419 (GRCm39) V244L probably benign Het
Eef2kmt A G 16: 5,063,222 (GRCm39) V306A probably benign Het
Enah A T 1: 181,763,293 (GRCm39) probably null Het
Fam171b T C 2: 83,683,949 (GRCm39) probably null Het
Fsip2 C T 2: 82,808,925 (GRCm39) T1748I possibly damaging Het
Gabrg2 C T 11: 41,862,559 (GRCm39) G175D probably damaging Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Hmcn1 G T 1: 150,458,047 (GRCm39) N33K probably damaging Het
Incenp T A 19: 9,855,770 (GRCm39) E514V unknown Het
Kank3 T C 17: 34,036,917 (GRCm39) S74P probably benign Het
Lrriq1 G T 10: 103,051,206 (GRCm39) N515K probably benign Het
Mfsd13b G A 7: 120,591,056 (GRCm39) D266N probably damaging Het
Neto1 T C 18: 86,422,998 (GRCm39) Y152H probably damaging Het
Nub1 C A 5: 24,900,533 (GRCm39) F145L probably benign Het
Nufip1 T C 14: 76,351,715 (GRCm39) probably null Het
Pard6g T A 18: 80,123,116 (GRCm39) V50E probably benign Het
Polr3a T C 14: 24,505,009 (GRCm39) I1084V possibly damaging Het
Rapgef5 A C 12: 117,703,379 (GRCm39) N431T probably damaging Het
Rassf9 A T 10: 102,381,205 (GRCm39) T196S probably damaging Het
Rrp12 T C 19: 41,865,029 (GRCm39) Y764C probably benign Het
Slfn8 T C 11: 82,908,550 (GRCm39) probably null Het
Smox T A 2: 131,363,026 (GRCm39) V265D probably damaging Het
Sult1b1 T C 5: 87,678,510 (GRCm39) I105V probably benign Het
Sycp2 T C 2: 178,045,554 (GRCm39) D22G probably damaging Het
Tbck G A 3: 132,456,977 (GRCm39) M630I possibly damaging Het
Tenm4 G C 7: 96,486,538 (GRCm39) G965R possibly damaging Het
Trappc10 G A 10: 78,023,694 (GRCm39) T1258I probably damaging Het
Tssk1 G A 16: 17,713,123 (GRCm39) G303S probably benign Het
Usp42 G A 5: 143,707,401 (GRCm39) T260M probably damaging Het
Wdr43 T A 17: 71,955,772 (GRCm39) V479E probably damaging Het
Xpo7 G A 14: 70,921,171 (GRCm39) T599I probably damaging Het
Zfp553 A G 7: 126,836,013 (GRCm39) K523E probably benign Het
Other mutations in Tstd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00232:Tstd2 APN 4 46,120,002 (GRCm39) unclassified probably benign
IGL02832:Tstd2 APN 4 46,124,949 (GRCm39) missense probably damaging 1.00
curative UTSW 4 46,116,960 (GRCm39) missense probably damaging 1.00
R1991:Tstd2 UTSW 4 46,120,563 (GRCm39) missense probably benign 0.00
R2154:Tstd2 UTSW 4 46,129,235 (GRCm39) missense probably damaging 0.98
R4381:Tstd2 UTSW 4 46,119,933 (GRCm39) missense probably benign 0.01
R4643:Tstd2 UTSW 4 46,129,297 (GRCm39) missense possibly damaging 0.92
R4961:Tstd2 UTSW 4 46,120,467 (GRCm39) missense probably damaging 1.00
R5396:Tstd2 UTSW 4 46,135,542 (GRCm39) missense probably benign 0.00
R7196:Tstd2 UTSW 4 46,119,955 (GRCm39) missense probably damaging 1.00
R7535:Tstd2 UTSW 4 46,116,960 (GRCm39) missense probably damaging 1.00
R7991:Tstd2 UTSW 4 46,133,646 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TTTTCTCAGCAGACCTGGAG -3'
(R):5'- GCTTTGATGGAGACGCAGAG -3'

Sequencing Primer
(F):5'- TCAGCAGACCTGGAGCTCAG -3'
(R):5'- CACTTCAGTCAGATTAGGACAGCTAG -3'
Posted On 2016-07-22