|Institutional Source||Beutler Lab|
|Gene Name||C-reactive protein, pentraxin-related|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5213 (G1)|
|Chromosomal Location||172698055-172833031 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 172698519 bp|
|Amino Acid Change||Histidine to Arginine at position 57 (H57R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000044665 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000038495]|
|Predicted Effect||probably benign
AA Change: H57R
PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
AA Change: H57R
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Crp||
(F):5'- ATCAGGATCAGGGTAGCTGTG -3'
(R):5'- GTTGGAGCCTCAGGAATCTCTG -3'
(F):5'- TTGATCCCAAACTCTACCTGTAAGGG -3'
(R):5'- GGAATCTCTGAAACCATGAATCG -3'