Incidental Mutation 'R5277:Fyb2'
ID 403991
Institutional Source Beutler Lab
Gene Symbol Fyb2
Ensembl Gene ENSMUSG00000078612
Gene Name FYN binding protein 2
Synonyms 1700024P16Rik
MMRRC Submission 042864-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R5277 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 104770653-104874060 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 104872876 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Asparagine at position 686 (D686N)
Ref Sequence ENSEMBL: ENSMUSP00000102416 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106803] [ENSMUST00000106804]
AlphaFold A2A995
Predicted Effect probably damaging
Transcript: ENSMUST00000106803
AA Change: D750N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102415
Gene: ENSMUSG00000078612
AA Change: D750N

DomainStartEndE-ValueType
low complexity region 120 132 N/A INTRINSIC
low complexity region 340 349 N/A INTRINSIC
low complexity region 442 459 N/A INTRINSIC
low complexity region 537 549 N/A INTRINSIC
low complexity region 567 578 N/A INTRINSIC
low complexity region 682 697 N/A INTRINSIC
SH3 735 791 3.82e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000106804
AA Change: D686N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102416
Gene: ENSMUSG00000078612
AA Change: D686N

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
low complexity region 276 285 N/A INTRINSIC
low complexity region 378 395 N/A INTRINSIC
low complexity region 473 485 N/A INTRINSIC
low complexity region 503 514 N/A INTRINSIC
low complexity region 618 633 N/A INTRINSIC
SH3 671 727 3.82e0 SMART
Meta Mutation Damage Score 0.1493 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi1 T C 2: 22,884,660 (GRCm39) T54A probably damaging Het
Ablim1 T C 19: 57,143,693 (GRCm39) R89G probably damaging Het
Bco1 T A 8: 117,844,128 (GRCm39) probably null Het
Bhmt A T 13: 93,761,393 (GRCm39) M185K possibly damaging Het
Camk2d T C 3: 126,478,390 (GRCm39) probably benign Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Dcaf6 A G 1: 165,251,915 (GRCm39) S70P probably benign Het
Dclre1a C T 19: 56,533,164 (GRCm39) V477I possibly damaging Het
Dnah10 C T 5: 124,905,201 (GRCm39) P4021L probably damaging Het
Dusp10 A G 1: 183,769,204 (GRCm39) N57D possibly damaging Het
Fam13b G A 18: 34,595,243 (GRCm39) R374C probably benign Het
Glra3 G A 8: 56,444,242 (GRCm39) M67I possibly damaging Het
Gm14325 G A 2: 177,474,777 (GRCm39) H102Y possibly damaging Het
Gm6180 A G 8: 42,700,177 (GRCm39) noncoding transcript Het
Grin2c A G 11: 115,144,639 (GRCm39) V629A probably damaging Het
Kif4-ps A T 12: 101,112,186 (GRCm39) noncoding transcript Het
Mc3r T C 2: 172,091,707 (GRCm39) F310L probably damaging Het
Myh4 A G 11: 67,143,180 (GRCm39) D1036G probably damaging Het
Myh6 A G 14: 55,194,019 (GRCm39) I790T probably benign Het
Myo15a C A 11: 60,367,940 (GRCm39) Y233* probably null Het
Nckap5 A T 1: 125,954,277 (GRCm39) C758* probably null Het
Neurog3 T A 10: 61,969,632 (GRCm39) Y36N probably damaging Het
Nlrp4e T C 7: 23,020,863 (GRCm39) L450P probably benign Het
Or52d13 A T 7: 103,110,148 (GRCm39) L84H probably damaging Het
Otog A G 7: 45,896,045 (GRCm39) E170G possibly damaging Het
Ppp2r2b G T 18: 42,874,207 (GRCm39) T41K probably damaging Het
Prmt5 A T 14: 54,747,399 (GRCm39) D459E probably benign Het
Ric8b G A 10: 84,783,516 (GRCm39) V125M probably damaging Het
Rptor A G 11: 119,713,782 (GRCm39) S4G probably damaging Het
Rslcan18 T G 13: 67,246,498 (GRCm39) E371D probably benign Het
Scaf11 A T 15: 96,317,107 (GRCm39) F819Y probably damaging Het
Sema6a A T 18: 47,409,611 (GRCm39) probably benign Het
Snx29 C T 16: 11,217,688 (GRCm39) T163I possibly damaging Het
Sphkap T C 1: 83,253,885 (GRCm39) N1288S probably benign Het
Tmbim7 G A 5: 3,723,192 (GRCm39) probably null Het
Tmem63c T A 12: 87,104,531 (GRCm39) probably null Het
Tmem69 A G 4: 116,410,458 (GRCm39) F171L probably benign Het
Urod A T 4: 116,847,482 (GRCm39) probably benign Het
Vmn1r37 A T 6: 66,708,460 (GRCm39) I29L probably benign Het
Vmn2r102 A G 17: 19,914,393 (GRCm39) T653A possibly damaging Het
Vmn2r75 A C 7: 85,815,500 (GRCm39) S121R probably benign Het
Vwde T C 6: 13,186,995 (GRCm39) T831A probably benign Het
Wdr70 C T 15: 8,006,465 (GRCm39) W362* probably null Het
Zfat A G 15: 68,037,758 (GRCm39) C906R probably damaging Het
Zfp7 T C 15: 76,765,403 (GRCm39) V32A probably damaging Het
Other mutations in Fyb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00664:Fyb2 APN 4 104,872,913 (GRCm39) missense probably damaging 1.00
IGL01155:Fyb2 APN 4 104,856,583 (GRCm39) missense probably benign 0.00
IGL01632:Fyb2 APN 4 104,853,008 (GRCm39) missense probably benign
IGL01746:Fyb2 APN 4 104,802,404 (GRCm39) missense probably benign 0.01
IGL02381:Fyb2 APN 4 104,805,863 (GRCm39) splice site probably benign
IGL02590:Fyb2 APN 4 104,836,250 (GRCm39) missense probably damaging 1.00
IGL02885:Fyb2 APN 4 104,861,118 (GRCm39) missense probably damaging 0.99
IGL03114:Fyb2 APN 4 104,852,975 (GRCm39) missense probably damaging 0.97
IGL03189:Fyb2 APN 4 104,872,939 (GRCm39) missense probably damaging 1.00
IGL03231:Fyb2 APN 4 104,843,460 (GRCm39) nonsense probably null
R0076:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R0662:Fyb2 UTSW 4 104,852,895 (GRCm39) missense possibly damaging 0.46
R0723:Fyb2 UTSW 4 104,873,063 (GRCm39) missense probably benign 0.00
R1216:Fyb2 UTSW 4 104,852,903 (GRCm39) missense possibly damaging 0.86
R1672:Fyb2 UTSW 4 104,808,059 (GRCm39) missense probably benign 0.10
R1710:Fyb2 UTSW 4 104,861,113 (GRCm39) missense probably damaging 1.00
R1900:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R1965:Fyb2 UTSW 4 104,770,846 (GRCm39) missense probably benign 0.00
R2106:Fyb2 UTSW 4 104,802,769 (GRCm39) missense probably benign 0.01
R5191:Fyb2 UTSW 4 104,852,994 (GRCm39) missense possibly damaging 0.88
R5236:Fyb2 UTSW 4 104,805,957 (GRCm39) missense probably benign 0.00
R5502:Fyb2 UTSW 4 104,802,521 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,872,841 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,870,518 (GRCm39) missense probably damaging 1.00
R6167:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R6169:Fyb2 UTSW 4 104,857,713 (GRCm39) missense probably benign 0.16
R6371:Fyb2 UTSW 4 104,852,975 (GRCm39) missense probably damaging 0.97
R6582:Fyb2 UTSW 4 104,802,739 (GRCm39) missense probably benign 0.00
R6713:Fyb2 UTSW 4 104,847,432 (GRCm39) missense probably benign 0.16
R6719:Fyb2 UTSW 4 104,867,656 (GRCm39) missense probably benign 0.07
R7484:Fyb2 UTSW 4 104,870,499 (GRCm39) missense probably benign 0.01
R7534:Fyb2 UTSW 4 104,856,545 (GRCm39) nonsense probably null
R7590:Fyb2 UTSW 4 104,802,443 (GRCm39) missense probably benign 0.01
R7699:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R7700:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R8041:Fyb2 UTSW 4 104,857,681 (GRCm39) missense possibly damaging 0.82
R8298:Fyb2 UTSW 4 104,806,028 (GRCm39) missense probably damaging 0.99
R8300:Fyb2 UTSW 4 104,857,689 (GRCm39) missense probably damaging 1.00
R8755:Fyb2 UTSW 4 104,861,086 (GRCm39) missense unknown
R8817:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R8873:Fyb2 UTSW 4 104,856,538 (GRCm39) missense probably damaging 1.00
R8914:Fyb2 UTSW 4 104,857,700 (GRCm39) missense probably benign 0.09
R9224:Fyb2 UTSW 4 104,853,105 (GRCm39) missense probably benign 0.44
R9434:Fyb2 UTSW 4 104,847,534 (GRCm39) missense probably damaging 0.99
R9512:Fyb2 UTSW 4 104,853,100 (GRCm39) missense probably benign 0.00
R9589:Fyb2 UTSW 4 104,872,833 (GRCm39) missense probably damaging 1.00
R9634:Fyb2 UTSW 4 104,856,579 (GRCm39) nonsense probably null
R9758:Fyb2 UTSW 4 104,802,961 (GRCm39) missense probably benign 0.01
X0018:Fyb2 UTSW 4 104,802,407 (GRCm39) missense probably benign 0.04
Z1176:Fyb2 UTSW 4 104,770,857 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AGGGAGTTCCACTGTAATATCCCC -3'
(R):5'- GAGCACATATCCATCTGTAGAAAC -3'

Sequencing Primer
(F):5'- ATCCCCATCATTTATTTTGTCCATG -3'
(R):5'- CAAAACTCACTTTAGTAACCTGAGAG -3'
Posted On 2016-07-22