Incidental Mutation 'R5277:Snx29'
ID 404022
Institutional Source Beutler Lab
Gene Symbol Snx29
Ensembl Gene ENSMUSG00000071669
Gene Name sorting nexin 29
Synonyms Rundc2a, Gm11170, LOC385605, LOC381035, 4933437K13Rik
MMRRC Submission 042864-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5277 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 11140772-11573336 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 11217688 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 163 (T163I)
Ref Sequence ENSEMBL: ENSMUSP00000111481 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115814] [ENSMUST00000180792]
AlphaFold Q9D3S3
Predicted Effect possibly damaging
Transcript: ENSMUST00000115814
AA Change: T163I

PolyPhen 2 Score 0.819 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000111481
Gene: ENSMUSG00000071669
AA Change: T163I

DomainStartEndE-ValueType
low complexity region 64 74 N/A INTRINSIC
RUN 115 178 7.89e-26 SMART
internal_repeat_1 192 211 2.98e-5 PROSPERO
internal_repeat_1 203 222 2.98e-5 PROSPERO
low complexity region 252 262 N/A INTRINSIC
low complexity region 270 275 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000180792
AA Change: T163I

PolyPhen 2 Score 0.811 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000138025
Gene: ENSMUSG00000071669
AA Change: T163I

DomainStartEndE-ValueType
low complexity region 64 74 N/A INTRINSIC
RUN 115 178 7.89e-26 SMART
internal_repeat_1 192 211 2.63e-5 PROSPERO
internal_repeat_1 203 222 2.63e-5 PROSPERO
low complexity region 252 262 N/A INTRINSIC
low complexity region 270 275 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
low complexity region 445 462 N/A INTRINSIC
coiled coil region 467 548 N/A INTRINSIC
PX 661 764 3.13e-9 SMART
Meta Mutation Damage Score 0.0932 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abi1 T C 2: 22,884,660 (GRCm39) T54A probably damaging Het
Ablim1 T C 19: 57,143,693 (GRCm39) R89G probably damaging Het
Bco1 T A 8: 117,844,128 (GRCm39) probably null Het
Bhmt A T 13: 93,761,393 (GRCm39) M185K possibly damaging Het
Camk2d T C 3: 126,478,390 (GRCm39) probably benign Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Dcaf6 A G 1: 165,251,915 (GRCm39) S70P probably benign Het
Dclre1a C T 19: 56,533,164 (GRCm39) V477I possibly damaging Het
Dnah10 C T 5: 124,905,201 (GRCm39) P4021L probably damaging Het
Dusp10 A G 1: 183,769,204 (GRCm39) N57D possibly damaging Het
Fam13b G A 18: 34,595,243 (GRCm39) R374C probably benign Het
Fyb2 G A 4: 104,872,876 (GRCm39) D686N probably damaging Het
Glra3 G A 8: 56,444,242 (GRCm39) M67I possibly damaging Het
Gm14325 G A 2: 177,474,777 (GRCm39) H102Y possibly damaging Het
Gm6180 A G 8: 42,700,177 (GRCm39) noncoding transcript Het
Grin2c A G 11: 115,144,639 (GRCm39) V629A probably damaging Het
Kif4-ps A T 12: 101,112,186 (GRCm39) noncoding transcript Het
Mc3r T C 2: 172,091,707 (GRCm39) F310L probably damaging Het
Myh4 A G 11: 67,143,180 (GRCm39) D1036G probably damaging Het
Myh6 A G 14: 55,194,019 (GRCm39) I790T probably benign Het
Myo15a C A 11: 60,367,940 (GRCm39) Y233* probably null Het
Nckap5 A T 1: 125,954,277 (GRCm39) C758* probably null Het
Neurog3 T A 10: 61,969,632 (GRCm39) Y36N probably damaging Het
Nlrp4e T C 7: 23,020,863 (GRCm39) L450P probably benign Het
Or52d13 A T 7: 103,110,148 (GRCm39) L84H probably damaging Het
Otog A G 7: 45,896,045 (GRCm39) E170G possibly damaging Het
Ppp2r2b G T 18: 42,874,207 (GRCm39) T41K probably damaging Het
Prmt5 A T 14: 54,747,399 (GRCm39) D459E probably benign Het
Ric8b G A 10: 84,783,516 (GRCm39) V125M probably damaging Het
Rptor A G 11: 119,713,782 (GRCm39) S4G probably damaging Het
Rslcan18 T G 13: 67,246,498 (GRCm39) E371D probably benign Het
Scaf11 A T 15: 96,317,107 (GRCm39) F819Y probably damaging Het
Sema6a A T 18: 47,409,611 (GRCm39) probably benign Het
Sphkap T C 1: 83,253,885 (GRCm39) N1288S probably benign Het
Tmbim7 G A 5: 3,723,192 (GRCm39) probably null Het
Tmem63c T A 12: 87,104,531 (GRCm39) probably null Het
Tmem69 A G 4: 116,410,458 (GRCm39) F171L probably benign Het
Urod A T 4: 116,847,482 (GRCm39) probably benign Het
Vmn1r37 A T 6: 66,708,460 (GRCm39) I29L probably benign Het
Vmn2r102 A G 17: 19,914,393 (GRCm39) T653A possibly damaging Het
Vmn2r75 A C 7: 85,815,500 (GRCm39) S121R probably benign Het
Vwde T C 6: 13,186,995 (GRCm39) T831A probably benign Het
Wdr70 C T 15: 8,006,465 (GRCm39) W362* probably null Het
Zfat A G 15: 68,037,758 (GRCm39) C906R probably damaging Het
Zfp7 T C 15: 76,765,403 (GRCm39) V32A probably damaging Het
Other mutations in Snx29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00733:Snx29 APN 16 11,221,366 (GRCm39) missense probably damaging 0.97
IGL02207:Snx29 APN 16 11,556,216 (GRCm39) missense probably damaging 1.00
PIT1430001:Snx29 UTSW 16 11,221,488 (GRCm39) missense probably benign 0.00
PIT4810001:Snx29 UTSW 16 11,218,845 (GRCm39) missense probably damaging 1.00
R0240:Snx29 UTSW 16 11,478,417 (GRCm39) missense probably damaging 1.00
R0240:Snx29 UTSW 16 11,478,417 (GRCm39) missense probably damaging 1.00
R0276:Snx29 UTSW 16 11,556,237 (GRCm39) missense probably benign 0.01
R0506:Snx29 UTSW 16 11,213,167 (GRCm39) missense probably benign 0.15
R0621:Snx29 UTSW 16 11,223,651 (GRCm39) splice site probably null
R0975:Snx29 UTSW 16 11,165,735 (GRCm39) missense possibly damaging 0.66
R1225:Snx29 UTSW 16 11,238,550 (GRCm39) intron probably benign
R1406:Snx29 UTSW 16 11,217,657 (GRCm39) missense probably benign 0.38
R1406:Snx29 UTSW 16 11,217,657 (GRCm39) missense probably benign 0.38
R1452:Snx29 UTSW 16 11,449,335 (GRCm39) missense probably damaging 1.00
R1515:Snx29 UTSW 16 11,217,701 (GRCm39) critical splice donor site probably null
R1874:Snx29 UTSW 16 11,185,545 (GRCm39) missense probably benign 0.01
R1953:Snx29 UTSW 16 11,217,647 (GRCm39) nonsense probably null
R1978:Snx29 UTSW 16 11,185,588 (GRCm39) missense probably benign 0.23
R2054:Snx29 UTSW 16 11,449,356 (GRCm39) missense probably damaging 1.00
R2105:Snx29 UTSW 16 11,328,898 (GRCm39) missense possibly damaging 0.72
R2128:Snx29 UTSW 16 11,218,835 (GRCm39) missense probably damaging 0.98
R2152:Snx29 UTSW 16 11,218,707 (GRCm39) missense possibly damaging 0.95
R2912:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R2913:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R2914:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R4468:Snx29 UTSW 16 11,238,565 (GRCm39) splice site probably null
R4469:Snx29 UTSW 16 11,238,565 (GRCm39) splice site probably null
R4612:Snx29 UTSW 16 11,265,359 (GRCm39) missense probably damaging 0.99
R4744:Snx29 UTSW 16 11,167,773 (GRCm39) nonsense probably null
R4798:Snx29 UTSW 16 11,238,600 (GRCm39) missense probably damaging 1.00
R5000:Snx29 UTSW 16 11,221,371 (GRCm39) missense probably damaging 0.99
R5165:Snx29 UTSW 16 11,238,639 (GRCm39) missense probably damaging 0.98
R5207:Snx29 UTSW 16 11,556,227 (GRCm39) missense probably damaging 1.00
R5235:Snx29 UTSW 16 11,231,110 (GRCm39) missense possibly damaging 0.94
R5274:Snx29 UTSW 16 11,556,268 (GRCm39) missense probably damaging 1.00
R5462:Snx29 UTSW 16 11,328,876 (GRCm39) missense possibly damaging 0.89
R5655:Snx29 UTSW 16 11,573,185 (GRCm39) missense probably damaging 1.00
R6036:Snx29 UTSW 16 11,556,301 (GRCm39) splice site probably null
R6036:Snx29 UTSW 16 11,556,301 (GRCm39) splice site probably null
R6326:Snx29 UTSW 16 11,221,430 (GRCm39) missense probably benign
R6576:Snx29 UTSW 16 11,532,920 (GRCm39) critical splice donor site probably null
R7406:Snx29 UTSW 16 11,573,180 (GRCm39) missense probably damaging 1.00
R7552:Snx29 UTSW 16 11,238,649 (GRCm39) critical splice donor site probably null
R7555:Snx29 UTSW 16 11,218,806 (GRCm39) missense probably benign 0.02
R7736:Snx29 UTSW 16 11,185,588 (GRCm39) missense probably benign 0.23
R7962:Snx29 UTSW 16 11,231,221 (GRCm39) critical splice donor site probably null
R8101:Snx29 UTSW 16 11,389,580 (GRCm39) missense probably benign 0.16
R8415:Snx29 UTSW 16 11,265,291 (GRCm39) missense probably damaging 1.00
R8549:Snx29 UTSW 16 11,532,920 (GRCm39) critical splice donor site probably null
R9010:Snx29 UTSW 16 11,449,391 (GRCm39) missense probably benign 0.00
R9091:Snx29 UTSW 16 11,213,155 (GRCm39) missense probably benign 0.33
R9099:Snx29 UTSW 16 11,478,435 (GRCm39) missense probably damaging 1.00
R9176:Snx29 UTSW 16 11,236,728 (GRCm39) missense probably benign
R9258:Snx29 UTSW 16 11,532,799 (GRCm39) missense possibly damaging 0.78
R9270:Snx29 UTSW 16 11,213,155 (GRCm39) missense probably benign 0.33
R9672:Snx29 UTSW 16 11,478,515 (GRCm39) missense probably benign 0.00
R9778:Snx29 UTSW 16 11,223,609 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- AGACCAAACTTCTTCTGGGTG -3'
(R):5'- TTTACAGTTCACCTGCCAGGC -3'

Sequencing Primer
(F):5'- GTGACAGACCAGGCGGG -3'
(R):5'- TCTTCAACCAAGTGCATCATCCG -3'
Posted On 2016-07-22