Incidental Mutation 'R5302:Vmn1r22'
ID |
404296 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r22
|
Ensembl Gene |
ENSMUSG00000115091 |
Gene Name |
vomeronasal 1 receptor 22 |
Synonyms |
V1rc23 |
MMRRC Submission |
042885-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.095)
|
Stock # |
R5302 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
6 |
Chromosomal Location |
57877067-57877975 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 57877960 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Aspartic acid
at position 6
(N6D)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154301
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177435]
[ENSMUST00000227342]
[ENSMUST00000227650]
[ENSMUST00000228076]
[ENSMUST00000228257]
[ENSMUST00000228322]
[ENSMUST00000228905]
|
AlphaFold |
Q8R2D1 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000177435
AA Change: N6D
PolyPhen 2
Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000135207 Gene: ENSMUSG00000114982 AA Change: N6D
Domain | Start | End | E-Value | Type |
Pfam:V1R
|
28 |
293 |
3.9e-57 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000227342
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227650
AA Change: N6D
PolyPhen 2
Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228076
AA Change: N6D
PolyPhen 2
Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228257
AA Change: N6D
PolyPhen 2
Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228322
AA Change: N6D
PolyPhen 2
Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228905
|
Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 96.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 41 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca12 |
A |
G |
1: 71,323,111 (GRCm39) |
V1657A |
possibly damaging |
Het |
Abca8b |
C |
A |
11: 109,868,639 (GRCm39) |
G175V |
probably damaging |
Het |
Acot5 |
A |
G |
12: 84,120,215 (GRCm39) |
Y190C |
probably damaging |
Het |
Ascc3 |
T |
A |
10: 50,583,873 (GRCm39) |
Y941N |
probably benign |
Het |
BC035947 |
A |
T |
1: 78,488,599 (GRCm39) |
M1K |
probably null |
Het |
C2cd5 |
A |
G |
6: 143,019,482 (GRCm39) |
C278R |
probably benign |
Het |
Cd200r1 |
G |
T |
16: 44,613,172 (GRCm39) |
L259F |
possibly damaging |
Het |
Clcn4 |
A |
G |
7: 7,297,050 (GRCm39) |
V136A |
possibly damaging |
Het |
Cntnap5a |
T |
C |
1: 116,085,300 (GRCm39) |
S413P |
probably benign |
Het |
Corin |
T |
A |
5: 72,473,441 (GRCm39) |
E748D |
probably benign |
Het |
Crtc2 |
G |
T |
3: 90,168,325 (GRCm39) |
G356V |
probably damaging |
Het |
D1Pas1 |
T |
A |
1: 186,701,642 (GRCm39) |
Y524N |
probably damaging |
Het |
Dlgap4 |
T |
C |
2: 156,602,818 (GRCm39) |
S147P |
probably damaging |
Het |
Eif1ad16 |
T |
A |
12: 87,985,316 (GRCm39) |
I76F |
probably damaging |
Het |
Enpp1 |
A |
T |
10: 24,527,288 (GRCm39) |
I633N |
probably benign |
Het |
Gm3095 |
A |
G |
14: 15,170,367 (GRCm39) |
D72G |
probably null |
Het |
Gm5449 |
C |
T |
13: 53,679,787 (GRCm39) |
|
noncoding transcript |
Het |
Gpx7 |
T |
C |
4: 108,258,111 (GRCm39) |
T161A |
probably benign |
Het |
Grip1 |
T |
C |
10: 119,855,982 (GRCm39) |
L236P |
probably damaging |
Het |
H2-Q2 |
G |
T |
17: 35,563,885 (GRCm39) |
R255S |
probably damaging |
Het |
Il17rc |
G |
T |
6: 113,459,997 (GRCm39) |
A648S |
possibly damaging |
Het |
Klhl12 |
A |
G |
1: 134,417,189 (GRCm39) |
E540G |
possibly damaging |
Het |
Mcm10 |
T |
C |
2: 5,012,181 (GRCm39) |
I135V |
probably benign |
Het |
Mrps26 |
C |
A |
2: 130,406,087 (GRCm39) |
T100K |
probably benign |
Het |
Nid2 |
A |
G |
14: 19,829,769 (GRCm39) |
T687A |
probably benign |
Het |
Npas3 |
A |
T |
12: 54,115,619 (GRCm39) |
D829V |
probably damaging |
Het |
Ocln |
T |
C |
13: 100,642,807 (GRCm39) |
D176G |
probably damaging |
Het |
Or11h6 |
A |
G |
14: 50,879,776 (GRCm39) |
|
probably null |
Het |
Pax3 |
A |
C |
1: 78,098,249 (GRCm39) |
M380R |
possibly damaging |
Het |
Pcdha3 |
A |
G |
18: 37,081,208 (GRCm39) |
E650G |
probably damaging |
Het |
Pdcd11 |
C |
A |
19: 47,096,083 (GRCm39) |
H668N |
probably damaging |
Het |
Polr3b |
T |
C |
10: 84,535,264 (GRCm39) |
Y858H |
possibly damaging |
Het |
Pus10 |
T |
C |
11: 23,617,416 (GRCm39) |
|
probably null |
Het |
Raver1 |
T |
C |
9: 20,986,677 (GRCm39) |
D739G |
probably damaging |
Het |
Skic3 |
G |
A |
13: 76,295,886 (GRCm39) |
E1050K |
possibly damaging |
Het |
Slc26a11 |
T |
C |
11: 119,254,276 (GRCm39) |
L198P |
probably damaging |
Het |
Slc44a3 |
A |
G |
3: 121,303,962 (GRCm39) |
V258A |
probably damaging |
Het |
Socs7 |
T |
A |
11: 97,280,025 (GRCm39) |
I524N |
probably damaging |
Het |
Steap4 |
T |
A |
5: 8,025,547 (GRCm39) |
L36* |
probably null |
Het |
Svep1 |
G |
C |
4: 58,096,183 (GRCm39) |
T1479S |
possibly damaging |
Het |
Ttn |
C |
A |
2: 76,547,619 (GRCm39) |
V32184F |
probably damaging |
Het |
|
Other mutations in Vmn1r22 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
R0089:Vmn1r22
|
UTSW |
6 |
57,877,513 (GRCm39) |
missense |
probably benign |
0.06 |
R0415:Vmn1r22
|
UTSW |
6 |
57,877,317 (GRCm39) |
missense |
probably benign |
0.18 |
R1132:Vmn1r22
|
UTSW |
6 |
57,877,826 (GRCm39) |
missense |
probably benign |
0.43 |
R1609:Vmn1r22
|
UTSW |
6 |
57,877,733 (GRCm39) |
nonsense |
probably null |
|
R1666:Vmn1r22
|
UTSW |
6 |
57,877,704 (GRCm39) |
missense |
probably benign |
0.07 |
R1668:Vmn1r22
|
UTSW |
6 |
57,877,704 (GRCm39) |
missense |
probably benign |
0.07 |
R1708:Vmn1r22
|
UTSW |
6 |
57,877,481 (GRCm39) |
missense |
possibly damaging |
0.46 |
R1796:Vmn1r22
|
UTSW |
6 |
57,877,134 (GRCm39) |
missense |
probably damaging |
1.00 |
R2359:Vmn1r22
|
UTSW |
6 |
57,877,974 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R4600:Vmn1r22
|
UTSW |
6 |
57,877,860 (GRCm39) |
missense |
probably damaging |
1.00 |
R5560:Vmn1r22
|
UTSW |
6 |
57,877,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R6026:Vmn1r22
|
UTSW |
6 |
57,877,390 (GRCm39) |
missense |
probably benign |
0.00 |
R6066:Vmn1r22
|
UTSW |
6 |
57,877,864 (GRCm39) |
missense |
probably benign |
0.01 |
R6343:Vmn1r22
|
UTSW |
6 |
57,877,563 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6639:Vmn1r22
|
UTSW |
6 |
57,877,699 (GRCm39) |
missense |
probably benign |
0.01 |
R7106:Vmn1r22
|
UTSW |
6 |
57,877,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R7683:Vmn1r22
|
UTSW |
6 |
57,877,404 (GRCm39) |
missense |
probably damaging |
1.00 |
R8126:Vmn1r22
|
UTSW |
6 |
57,877,669 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9216:Vmn1r22
|
UTSW |
6 |
57,877,257 (GRCm39) |
missense |
possibly damaging |
0.93 |
R9486:Vmn1r22
|
UTSW |
6 |
57,877,404 (GRCm39) |
missense |
probably damaging |
1.00 |
R9707:Vmn1r22
|
UTSW |
6 |
57,877,890 (GRCm39) |
missense |
probably benign |
0.37 |
R9722:Vmn1r22
|
UTSW |
6 |
57,877,631 (GRCm39) |
missense |
probably benign |
0.04 |
S24628:Vmn1r22
|
UTSW |
6 |
57,877,317 (GRCm39) |
missense |
probably benign |
0.18 |
|
Predicted Primers |
PCR Primer
(F):5'- AGTGACTCAAATAAGTCTGAAAGCC -3'
(R):5'- TTGGAGGGTATATAACAATGTAGGC -3'
Sequencing Primer
(F):5'- CAAATATCCCCTGCAGTGAGG -3'
(R):5'- CTGTGAGGTGAATCATAAGTTT -3'
|
Posted On |
2016-07-22 |