Incidental Mutation 'R5302:Vmn1r22'
ID 404296
Institutional Source Beutler Lab
Gene Symbol Vmn1r22
Ensembl Gene ENSMUSG00000115091
Gene Name vomeronasal 1 receptor 22
Synonyms V1rc23
MMRRC Submission 042885-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.095) question?
Stock # R5302 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 57877067-57877975 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 57877960 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 6 (N6D)
Ref Sequence ENSEMBL: ENSMUSP00000154301 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000177435] [ENSMUST00000227342] [ENSMUST00000227650] [ENSMUST00000228076] [ENSMUST00000228257] [ENSMUST00000228322] [ENSMUST00000228905]
AlphaFold Q8R2D1
Predicted Effect possibly damaging
Transcript: ENSMUST00000177435
AA Change: N6D

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000135207
Gene: ENSMUSG00000114982
AA Change: N6D

DomainStartEndE-ValueType
Pfam:V1R 28 293 3.9e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227342
Predicted Effect possibly damaging
Transcript: ENSMUST00000227650
AA Change: N6D

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228076
AA Change: N6D

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228257
AA Change: N6D

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect possibly damaging
Transcript: ENSMUST00000228322
AA Change: N6D

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
Predicted Effect probably benign
Transcript: ENSMUST00000228905
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,323,111 (GRCm39) V1657A possibly damaging Het
Abca8b C A 11: 109,868,639 (GRCm39) G175V probably damaging Het
Acot5 A G 12: 84,120,215 (GRCm39) Y190C probably damaging Het
Ascc3 T A 10: 50,583,873 (GRCm39) Y941N probably benign Het
BC035947 A T 1: 78,488,599 (GRCm39) M1K probably null Het
C2cd5 A G 6: 143,019,482 (GRCm39) C278R probably benign Het
Cd200r1 G T 16: 44,613,172 (GRCm39) L259F possibly damaging Het
Clcn4 A G 7: 7,297,050 (GRCm39) V136A possibly damaging Het
Cntnap5a T C 1: 116,085,300 (GRCm39) S413P probably benign Het
Corin T A 5: 72,473,441 (GRCm39) E748D probably benign Het
Crtc2 G T 3: 90,168,325 (GRCm39) G356V probably damaging Het
D1Pas1 T A 1: 186,701,642 (GRCm39) Y524N probably damaging Het
Dlgap4 T C 2: 156,602,818 (GRCm39) S147P probably damaging Het
Eif1ad16 T A 12: 87,985,316 (GRCm39) I76F probably damaging Het
Enpp1 A T 10: 24,527,288 (GRCm39) I633N probably benign Het
Gm3095 A G 14: 15,170,367 (GRCm39) D72G probably null Het
Gm5449 C T 13: 53,679,787 (GRCm39) noncoding transcript Het
Gpx7 T C 4: 108,258,111 (GRCm39) T161A probably benign Het
Grip1 T C 10: 119,855,982 (GRCm39) L236P probably damaging Het
H2-Q2 G T 17: 35,563,885 (GRCm39) R255S probably damaging Het
Il17rc G T 6: 113,459,997 (GRCm39) A648S possibly damaging Het
Klhl12 A G 1: 134,417,189 (GRCm39) E540G possibly damaging Het
Mcm10 T C 2: 5,012,181 (GRCm39) I135V probably benign Het
Mrps26 C A 2: 130,406,087 (GRCm39) T100K probably benign Het
Nid2 A G 14: 19,829,769 (GRCm39) T687A probably benign Het
Npas3 A T 12: 54,115,619 (GRCm39) D829V probably damaging Het
Ocln T C 13: 100,642,807 (GRCm39) D176G probably damaging Het
Or11h6 A G 14: 50,879,776 (GRCm39) probably null Het
Pax3 A C 1: 78,098,249 (GRCm39) M380R possibly damaging Het
Pcdha3 A G 18: 37,081,208 (GRCm39) E650G probably damaging Het
Pdcd11 C A 19: 47,096,083 (GRCm39) H668N probably damaging Het
Polr3b T C 10: 84,535,264 (GRCm39) Y858H possibly damaging Het
Pus10 T C 11: 23,617,416 (GRCm39) probably null Het
Raver1 T C 9: 20,986,677 (GRCm39) D739G probably damaging Het
Skic3 G A 13: 76,295,886 (GRCm39) E1050K possibly damaging Het
Slc26a11 T C 11: 119,254,276 (GRCm39) L198P probably damaging Het
Slc44a3 A G 3: 121,303,962 (GRCm39) V258A probably damaging Het
Socs7 T A 11: 97,280,025 (GRCm39) I524N probably damaging Het
Steap4 T A 5: 8,025,547 (GRCm39) L36* probably null Het
Svep1 G C 4: 58,096,183 (GRCm39) T1479S possibly damaging Het
Ttn C A 2: 76,547,619 (GRCm39) V32184F probably damaging Het
Other mutations in Vmn1r22
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0089:Vmn1r22 UTSW 6 57,877,513 (GRCm39) missense probably benign 0.06
R0415:Vmn1r22 UTSW 6 57,877,317 (GRCm39) missense probably benign 0.18
R1132:Vmn1r22 UTSW 6 57,877,826 (GRCm39) missense probably benign 0.43
R1609:Vmn1r22 UTSW 6 57,877,733 (GRCm39) nonsense probably null
R1666:Vmn1r22 UTSW 6 57,877,704 (GRCm39) missense probably benign 0.07
R1668:Vmn1r22 UTSW 6 57,877,704 (GRCm39) missense probably benign 0.07
R1708:Vmn1r22 UTSW 6 57,877,481 (GRCm39) missense possibly damaging 0.46
R1796:Vmn1r22 UTSW 6 57,877,134 (GRCm39) missense probably damaging 1.00
R2359:Vmn1r22 UTSW 6 57,877,974 (GRCm39) start codon destroyed probably null 1.00
R4600:Vmn1r22 UTSW 6 57,877,860 (GRCm39) missense probably damaging 1.00
R5560:Vmn1r22 UTSW 6 57,877,723 (GRCm39) missense probably damaging 1.00
R6026:Vmn1r22 UTSW 6 57,877,390 (GRCm39) missense probably benign 0.00
R6066:Vmn1r22 UTSW 6 57,877,864 (GRCm39) missense probably benign 0.01
R6343:Vmn1r22 UTSW 6 57,877,563 (GRCm39) missense possibly damaging 0.65
R6639:Vmn1r22 UTSW 6 57,877,699 (GRCm39) missense probably benign 0.01
R7106:Vmn1r22 UTSW 6 57,877,296 (GRCm39) missense probably damaging 1.00
R7683:Vmn1r22 UTSW 6 57,877,404 (GRCm39) missense probably damaging 1.00
R8126:Vmn1r22 UTSW 6 57,877,669 (GRCm39) missense possibly damaging 0.85
R9216:Vmn1r22 UTSW 6 57,877,257 (GRCm39) missense possibly damaging 0.93
R9486:Vmn1r22 UTSW 6 57,877,404 (GRCm39) missense probably damaging 1.00
R9707:Vmn1r22 UTSW 6 57,877,890 (GRCm39) missense probably benign 0.37
R9722:Vmn1r22 UTSW 6 57,877,631 (GRCm39) missense probably benign 0.04
S24628:Vmn1r22 UTSW 6 57,877,317 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- AGTGACTCAAATAAGTCTGAAAGCC -3'
(R):5'- TTGGAGGGTATATAACAATGTAGGC -3'

Sequencing Primer
(F):5'- CAAATATCCCCTGCAGTGAGG -3'
(R):5'- CTGTGAGGTGAATCATAAGTTT -3'
Posted On 2016-07-22