Incidental Mutation 'R5303:Or51a43'
ID 404351
Institutional Source Beutler Lab
Gene Symbol Or51a43
Ensembl Gene ENSMUSG00000110012
Gene Name olfactory receptor family 51 subfamily A member 43
Synonyms Olfr644, MOR13-1, GA_x6K02T2PBJ9-6803062-6802118
MMRRC Submission 042886-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.240) question?
Stock # R5303 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 103717292-103718236 bp(-) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) T to C at 103718239 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000149600 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077417] [ENSMUST00000077417] [ENSMUST00000077417] [ENSMUST00000138055] [ENSMUST00000213184] [ENSMUST00000213991]
AlphaFold Q8VH21
Predicted Effect probably benign
Transcript: ENSMUST00000077417
SMART Domains Protein: ENSMUSP00000076633
Gene: ENSMUSG00000110012

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2e-122 PFAM
Pfam:7TM_GPCR_Srsx 37 256 5.9e-8 PFAM
Pfam:7tm_1 43 294 1.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077417
SMART Domains Protein: ENSMUSP00000076633
Gene: ENSMUSG00000110012

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2e-122 PFAM
Pfam:7TM_GPCR_Srsx 37 256 5.9e-8 PFAM
Pfam:7tm_1 43 294 1.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000077417
SMART Domains Protein: ENSMUSP00000076633
Gene: ENSMUSG00000110012

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 2e-122 PFAM
Pfam:7TM_GPCR_Srsx 37 256 5.9e-8 PFAM
Pfam:7tm_1 43 294 1.4e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213184
Predicted Effect probably benign
Transcript: ENSMUST00000213991
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 95.9%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik C G 3: 124,199,999 (GRCm39) G531A probably damaging Het
4921504E06Rik A G 2: 19,521,110 (GRCm39) Y256H possibly damaging Het
Abcc12 C A 8: 87,236,415 (GRCm39) R1133L probably benign Het
Acss3 T A 10: 106,920,712 (GRCm39) T133S possibly damaging Het
Adra1d G A 2: 131,388,169 (GRCm39) P462L possibly damaging Het
Ank2 A T 3: 126,739,453 (GRCm39) probably benign Het
Arid2 G A 15: 96,290,349 (GRCm39) R1748Q probably damaging Het
B3glct C T 5: 149,677,488 (GRCm39) probably benign Het
C3ar1 A T 6: 122,826,794 (GRCm39) S474R probably damaging Het
Cd1d1 A G 3: 86,905,427 (GRCm39) F189L probably benign Het
Cd46 T C 1: 194,744,707 (GRCm39) I344V probably benign Het
Chrna1 T C 2: 73,396,618 (GRCm39) M426V probably benign Het
Cinp G A 12: 110,843,295 (GRCm39) T139M probably damaging Het
Cplane1 G A 15: 8,290,174 (GRCm39) probably null Het
Disp2 T C 2: 118,641,329 (GRCm39) probably benign Het
Dnaaf6rt G A 1: 31,262,537 (GRCm39) R173H probably damaging Het
Eapp G A 12: 54,739,703 (GRCm39) P38L probably damaging Het
Eif4g3 T C 4: 137,853,873 (GRCm39) S480P probably benign Het
Epb41l3 G C 17: 69,564,444 (GRCm39) E390Q probably damaging Het
Fermt1 T C 2: 132,753,259 (GRCm39) probably null Het
Foxf2 T A 13: 31,810,463 (GRCm39) F134Y possibly damaging Het
Foxp2 T A 6: 15,324,636 (GRCm39) C95S probably benign Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gria1 A G 11: 57,133,851 (GRCm39) T577A probably benign Het
Hal A G 10: 93,352,227 (GRCm39) probably benign Het
Hdac7 C A 15: 97,695,899 (GRCm39) E670D probably damaging Het
Islr2 A T 9: 58,115,558 (GRCm39) probably benign Het
Itpr3 T C 17: 27,335,663 (GRCm39) Y2258H probably benign Het
Mical3 G T 6: 120,936,941 (GRCm39) T1195K probably benign Het
Myh1 T C 11: 67,092,843 (GRCm39) S46P probably benign Het
Mylk3 T A 8: 86,077,105 (GRCm39) I444F probably damaging Het
Nlrc3 A T 16: 3,781,478 (GRCm39) C644S probably benign Het
Notch1 C T 2: 26,368,631 (GRCm39) V553M probably benign Het
Or10g9 A G 9: 39,911,884 (GRCm39) I213T probably damaging Het
Or4a72 T A 2: 89,405,345 (GRCm39) I242F possibly damaging Het
Or5b102 T A 19: 13,041,139 (GRCm39) Y121* probably null Het
Postn A G 3: 54,285,018 (GRCm39) T669A probably damaging Het
Ppp5c G T 7: 16,739,209 (GRCm39) Q472K probably benign Het
Qsox1 T C 1: 155,655,039 (GRCm39) H708R probably benign Het
Rhbdl2 A G 4: 123,704,014 (GRCm39) probably benign Het
Ryr1 C T 7: 28,767,907 (GRCm39) E2884K probably damaging Het
Saysd1 T C 14: 20,133,026 (GRCm39) T44A probably benign Het
Septin14 T A 5: 129,766,712 (GRCm39) M290L possibly damaging Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Slc38a8 C A 8: 120,212,780 (GRCm39) V294L possibly damaging Het
Spdye4b C T 5: 143,188,158 (GRCm39) T217I probably benign Het
Sugp2 T A 8: 70,694,827 (GRCm39) probably benign Het
Syne1 T C 10: 5,370,464 (GRCm39) T232A probably benign Het
Tbc1d5 A T 17: 51,043,228 (GRCm39) D753E probably benign Het
Tmed1 G T 9: 21,421,343 (GRCm39) Q44K possibly damaging Het
Ttc6 T A 12: 57,622,606 (GRCm39) S2T possibly damaging Het
Ube4b T C 4: 149,468,260 (GRCm39) D172G probably damaging Het
Vmn1r235 C A 17: 21,482,268 (GRCm39) Q198K probably benign Het
Wdfy3 T C 5: 102,100,849 (GRCm39) H256R probably damaging Het
Zfat A T 15: 67,982,335 (GRCm39) H1059Q probably damaging Het
Zfp758 A G 17: 22,593,842 (GRCm39) I77M probably benign Het
Zfp850 C T 7: 27,707,838 (GRCm39) A2T probably damaging Het
Zfyve1 A T 12: 83,621,830 (GRCm39) N188K probably damaging Het
Zyg11a C T 4: 108,041,629 (GRCm39) probably null Het
Other mutations in Or51a43
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01614:Or51a43 APN 7 103,717,576 (GRCm39) missense probably benign 0.00
IGL02937:Or51a43 APN 7 103,718,056 (GRCm39) missense probably damaging 0.99
IGL03188:Or51a43 APN 7 103,717,945 (GRCm39) missense possibly damaging 0.89
FR4737:Or51a43 UTSW 7 103,720,499 (GRCm39) start gained probably benign
R0467:Or51a43 UTSW 7 103,717,332 (GRCm39) missense probably benign 0.07
R1310:Or51a43 UTSW 7 103,717,805 (GRCm39) missense probably benign
R1457:Or51a43 UTSW 7 103,717,666 (GRCm39) missense probably damaging 1.00
R1619:Or51a43 UTSW 7 103,717,738 (GRCm39) missense probably damaging 1.00
R1874:Or51a43 UTSW 7 103,717,336 (GRCm39) missense probably null 1.00
R2428:Or51a43 UTSW 7 103,717,675 (GRCm39) nonsense probably null
R2922:Or51a43 UTSW 7 103,717,794 (GRCm39) missense probably benign 0.09
R2923:Or51a43 UTSW 7 103,717,794 (GRCm39) missense probably benign 0.09
R3929:Or51a43 UTSW 7 103,717,791 (GRCm39) missense probably benign 0.06
R4500:Or51a43 UTSW 7 103,717,402 (GRCm39) missense probably damaging 1.00
R5035:Or51a43 UTSW 7 103,717,614 (GRCm39) missense possibly damaging 0.95
R5464:Or51a43 UTSW 7 103,717,674 (GRCm39) missense possibly damaging 0.72
R5722:Or51a43 UTSW 7 103,717,930 (GRCm39) missense probably damaging 1.00
R5742:Or51a43 UTSW 7 103,717,412 (GRCm39) missense probably damaging 0.97
R6874:Or51a43 UTSW 7 103,717,396 (GRCm39) missense possibly damaging 0.50
R6940:Or51a43 UTSW 7 103,717,620 (GRCm39) missense possibly damaging 0.82
R7848:Or51a43 UTSW 7 103,717,302 (GRCm39) missense probably benign
R8343:Or51a43 UTSW 7 103,717,383 (GRCm39) missense probably damaging 1.00
R8714:Or51a43 UTSW 7 103,717,483 (GRCm39) missense probably damaging 0.97
R8866:Or51a43 UTSW 7 103,718,119 (GRCm39) missense probably damaging 0.99
R8909:Or51a43 UTSW 7 103,718,032 (GRCm39) missense probably damaging 1.00
R8966:Or51a43 UTSW 7 103,718,139 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACACACCAAGGTCATTTCCTG -3'
(R):5'- AATGAGCTCATTAGGGCAGC -3'

Sequencing Primer
(F):5'- TCATTTCCTGACAGCAGAGATAGG -3'
(R):5'- GCTCATTAGGGCAGCTCAAAG -3'
Posted On 2016-07-22