Incidental Mutation 'R5192:Becn2'
ID 405081
Institutional Source Beutler Lab
Gene Symbol Becn2
Ensembl Gene
Gene Name beclin 2
Synonyms Gm38100, LOC226720, Gm104
MMRRC Submission 042768-MU
Accession Numbers
Essential gene? Not available question?
Stock # R5192 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 175747895-175749791 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 175748408 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 158 (D158G)
Ref Sequence ENSEMBL: ENSMUSP00000144267 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000194391] [ENSMUST00000201297]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000194391
AA Change: D158G

PolyPhen 2 Score 0.242 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000144267
Gene: ENSMUSG00000104158
AA Change: D158G

DomainStartEndE-ValueType
low complexity region 12 26 N/A INTRINSIC
Pfam:APG6 126 440 1.2e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201297
AA Change: D158G

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000143887
Gene: ENSMUSG00000104158
AA Change: D158G

DomainStartEndE-ValueType
low complexity region 12 26 N/A INTRINSIC
Pfam:APG6 126 440 6.1e-95 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic and preweaning lethality with imapired basal and starvation-induced autophagy. Mice heterozygous for this allele exhibit increased susteptibility to obesity, insulin resistance and impaired glucosetolerance. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef25 A G 10: 127,020,978 (GRCm39) S303P probably damaging Het
Babam1 T C 8: 71,856,897 (GRCm39) V286A probably damaging Het
Cep192 T C 18: 67,968,075 (GRCm39) I853T probably benign Het
Cfap43 A T 19: 47,814,364 (GRCm39) W157R probably damaging Het
Dnah17 T C 11: 117,925,185 (GRCm39) T3883A possibly damaging Het
Dzip1 C T 14: 119,148,805 (GRCm39) M291I probably damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fbxw19 T C 9: 109,313,496 (GRCm39) Y234C probably benign Het
Gask1a T G 9: 121,794,727 (GRCm39) S294A probably benign Het
Gm9988 T C 8: 88,865,001 (GRCm39) probably benign Het
Gstm1 A G 3: 107,922,259 (GRCm39) probably null Het
Hsfy2 T A 1: 56,675,894 (GRCm39) K214N probably benign Het
Kat6a G A 8: 23,401,729 (GRCm39) R366H probably damaging Het
Kctd4 A G 14: 76,200,127 (GRCm39) T33A probably benign Het
Klrh1 T C 6: 129,748,721 (GRCm39) T99A probably benign Het
Marchf10 T C 11: 105,262,752 (GRCm39) H735R possibly damaging Het
Myo1g T C 11: 6,464,816 (GRCm39) D486G probably damaging Het
Or1e16 AGCGGTCGTAGGC AGC 11: 73,286,480 (GRCm39) probably null Het
Or5d46 A G 2: 88,170,092 (GRCm39) Y61C possibly damaging Het
Or8b1 T C 9: 38,400,101 (GRCm39) Y259H possibly damaging Het
Pif1 G T 9: 65,495,374 (GRCm39) A95S probably benign Het
Plppr2 T C 9: 21,852,428 (GRCm39) F104S probably damaging Het
Prep T C 10: 45,029,207 (GRCm39) Y536H probably benign Het
Slc22a30 G A 19: 8,321,757 (GRCm39) Q436* probably null Het
Tmtc2 G A 10: 105,026,038 (GRCm39) P810L probably damaging Het
Tollip C T 7: 141,445,854 (GRCm39) R9H probably damaging Het
Vmn2r57 A T 7: 41,077,363 (GRCm39) S268T probably damaging Het
Vps51 A G 19: 6,120,497 (GRCm39) V472A possibly damaging Het
Zfp608 C A 18: 55,031,569 (GRCm39) K790N probably damaging Het
Zfp661 A G 2: 127,418,982 (GRCm39) V386A possibly damaging Het
Other mutations in Becn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3623:Becn2 UTSW 1 175,748,197 (GRCm39) missense possibly damaging 0.88
R3922:Becn2 UTSW 1 175,748,852 (GRCm39) missense probably benign 0.00
R3925:Becn2 UTSW 1 175,748,852 (GRCm39) missense probably benign 0.00
R3926:Becn2 UTSW 1 175,748,852 (GRCm39) missense probably benign 0.00
R5275:Becn2 UTSW 1 175,748,336 (GRCm39) missense probably benign 0.07
R5666:Becn2 UTSW 1 175,749,179 (GRCm39) missense probably damaging 1.00
R5670:Becn2 UTSW 1 175,749,179 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCCTCCATGAGAACTATGAAC -3'
(R):5'- AAACAGAGTACTCGACCCTGTG -3'

Sequencing Primer
(F):5'- TCCATGAGAACTATGAACACTATCC -3'
(R):5'- GACCCTGTGCTGCTCATG -3'
Posted On 2016-07-22