Incidental Mutation 'R5300:Ly86'
ID 405615
Institutional Source Beutler Lab
Gene Symbol Ly86
Ensembl Gene ENSMUSG00000021423
Gene Name lymphocyte antigen 86
Synonyms MD-1, MD1
MMRRC Submission 042883-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R5300 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 37529276-37603012 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 37602588 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 160 (T160I)
Ref Sequence ENSEMBL: ENSMUSP00000021860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021860]
AlphaFold O88188
PDB Structure Crystal structure of mouse MD-1 in complex with phosphatidylcholine [X-RAY DIFFRACTION]
Crystal structure of mouse RP105/MD-1 complex [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000021860
AA Change: T160I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000021860
Gene: ENSMUSG00000021423
AA Change: T160I

DomainStartEndE-ValueType
ML 42 159 4.29e-26 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189445
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190684
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank1 A G 8: 23,622,517 (GRCm39) K1644E probably benign Het
C7 C A 15: 5,061,432 (GRCm39) G306W probably damaging Het
Ccdc185 A G 1: 182,575,645 (GRCm39) V348A probably benign Het
Cfap58 A T 19: 47,929,595 (GRCm39) I19F probably benign Het
Dnaaf2 C G 12: 69,245,002 (GRCm39) V20L probably damaging Het
Dpy19l3 A G 7: 35,426,735 (GRCm39) Y58H probably damaging Het
Dsc1 T C 18: 20,227,917 (GRCm39) S480G probably damaging Het
Eno4 G A 19: 58,943,982 (GRCm39) probably null Het
Gm136 T G 4: 34,750,930 (GRCm39) K114N probably damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lrrc37a T A 11: 103,347,784 (GRCm39) L2970F unknown Het
Mfsd4b1 A C 10: 39,879,027 (GRCm39) F290C probably benign Het
Minar1 A T 9: 89,485,252 (GRCm39) S48R probably damaging Het
Nbeal1 T G 1: 60,274,718 (GRCm39) Y376* probably null Het
Nipbl A T 15: 8,380,981 (GRCm39) S604T probably benign Het
Pml A C 9: 58,154,302 (GRCm39) N190K probably damaging Het
Rin3 C A 12: 102,335,929 (GRCm39) F533L probably benign Het
Scamp1 A G 13: 94,340,670 (GRCm39) V233A probably damaging Het
Sppl2c A T 11: 104,077,901 (GRCm39) N234Y possibly damaging Het
Tfap2b A G 1: 19,298,677 (GRCm39) K278R probably damaging Het
Tg A G 15: 66,550,704 (GRCm39) Y278C probably damaging Het
Trdn A G 10: 33,071,978 (GRCm39) E215G probably damaging Het
Tssk6 T C 8: 70,355,285 (GRCm39) S110P probably benign Het
Vmn2r15 A T 5: 109,441,974 (GRCm39) L153Q probably damaging Het
Wdr17 C T 8: 55,134,434 (GRCm39) G349R probably damaging Het
Zfp667 A G 7: 6,307,635 (GRCm39) H101R probably benign Het
Zfp772 A T 7: 7,207,157 (GRCm39) M178K probably benign Het
Other mutations in Ly86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02693:Ly86 APN 13 37,559,005 (GRCm39) missense probably damaging 1.00
R0082:Ly86 UTSW 13 37,602,513 (GRCm39) critical splice acceptor site probably null
R4605:Ly86 UTSW 13 37,558,987 (GRCm39) missense possibly damaging 0.81
R4642:Ly86 UTSW 13 37,560,877 (GRCm39) missense possibly damaging 0.53
R4665:Ly86 UTSW 13 37,559,010 (GRCm39) missense probably damaging 0.98
R4904:Ly86 UTSW 13 37,599,496 (GRCm39) missense possibly damaging 0.94
R5112:Ly86 UTSW 13 37,559,013 (GRCm39) missense probably damaging 1.00
R7145:Ly86 UTSW 13 37,560,986 (GRCm39) missense probably damaging 1.00
R7258:Ly86 UTSW 13 37,529,473 (GRCm39) missense probably benign
R8524:Ly86 UTSW 13 37,560,869 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACAGGTTCAGTACAGAAACTTCTTG -3'
(R):5'- TCTGGGAACATCTGTCCCTG -3'

Sequencing Primer
(F):5'- GGTGGGCAGATACACAATCCTTG -3'
(R):5'- GAACATCTGTCCCTGGAGCTAAG -3'
Posted On 2016-07-22