Incidental Mutation 'R5317:Plac8'
ID 405865
Institutional Source Beutler Lab
Gene Symbol Plac8
Ensembl Gene ENSMUSG00000029322
Gene Name placenta-specific 8
Synonyms D5Wsu111e, C15, onzin
MMRRC Submission 042900-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5317 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 100701591-100720111 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 100704345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000108531 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031264] [ENSMUST00000097437] [ENSMUST00000112910]
AlphaFold Q9JI48
Predicted Effect probably null
Transcript: ENSMUST00000031264
SMART Domains Protein: ENSMUSP00000031264
Gene: ENSMUSG00000029322

DomainStartEndE-ValueType
Pfam:PLAC8 23 102 4.3e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000097437
SMART Domains Protein: ENSMUSP00000108533
Gene: ENSMUSG00000029322

DomainStartEndE-ValueType
Pfam:PLAC8 23 103 1.3e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000112910
SMART Domains Protein: ENSMUSP00000108531
Gene: ENSMUSG00000029322

DomainStartEndE-ValueType
Pfam:PLAC8 23 103 1.3e-19 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.6%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit decreased neutrophil capacity for intracellular bacteria killing and impaired brown adipose tissue and thermoregulation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arih1 A C 9: 59,300,619 (GRCm39) H542Q probably benign Het
Ccn4 T G 15: 66,789,131 (GRCm39) S206A probably benign Het
Cnot8 T C 11: 58,004,029 (GRCm39) S155P probably damaging Het
Dcc C T 18: 71,517,226 (GRCm39) E810K possibly damaging Het
Dmrt2 T C 19: 25,650,844 (GRCm39) V10A probably benign Het
Dnah17 G A 11: 118,018,109 (GRCm39) R129W possibly damaging Het
Eif4a3 G T 11: 119,185,490 (GRCm39) H117N probably damaging Het
Fhip2a T A 19: 57,370,141 (GRCm39) probably null Het
Gpr179 T A 11: 97,228,671 (GRCm39) Q1161H probably damaging Het
Grm1 T G 10: 10,622,443 (GRCm39) M427L possibly damaging Het
Grxcr2 T A 18: 42,131,916 (GRCm39) H51L probably damaging Het
Il1rn C T 2: 24,239,554 (GRCm39) T150I probably benign Het
Kcnc4 C T 3: 107,366,055 (GRCm39) R51H probably damaging Het
Kcnh3 T C 15: 99,125,822 (GRCm39) S160P probably benign Het
Lrrc37 T C 11: 103,504,971 (GRCm39) I2332M possibly damaging Het
Mcm9 G A 10: 53,414,330 (GRCm39) P250L probably damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Mtmr2 T C 9: 13,704,475 (GRCm39) F201L probably benign Het
Or8s5 G A 15: 98,238,246 (GRCm39) A208V probably benign Het
Pan3 T C 5: 147,480,020 (GRCm39) probably null Het
Pcdhgb7 T A 18: 37,885,887 (GRCm39) D352E probably benign Het
Pdgfa A G 5: 138,974,102 (GRCm39) probably null Het
Pkhd1 T C 1: 20,520,528 (GRCm39) D1938G probably damaging Het
Rab11fip3 T C 17: 26,287,052 (GRCm39) E367G possibly damaging Het
Sgo2a C T 1: 58,054,683 (GRCm39) P289L probably benign Het
Slc22a18 T C 7: 143,052,896 (GRCm39) Y374H probably damaging Het
Slco2a1 T C 9: 102,956,778 (GRCm39) V530A probably benign Het
Spty2d1 A T 7: 46,648,049 (GRCm39) S293R possibly damaging Het
Stt3b G T 9: 115,081,578 (GRCm39) Y569* probably null Het
Tas2r140 A G 6: 133,032,543 (GRCm39) Y72H probably benign Het
Usp35 C T 7: 96,960,846 (GRCm39) R860H probably damaging Het
Vmn2r130 T A 17: 23,282,557 (GRCm39) M79K probably benign Het
Vsig10l T C 7: 43,114,247 (GRCm39) S190P probably damaging Het
Wwc2 C T 8: 48,300,590 (GRCm39) D958N unknown Het
Zfp318 AAGAAGG A 17: 46,723,463 (GRCm39) probably benign Het
Other mutations in Plac8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0021:Plac8 UTSW 5 100,704,434 (GRCm39) missense probably benign 0.03
R0021:Plac8 UTSW 5 100,704,434 (GRCm39) missense probably benign 0.03
R1023:Plac8 UTSW 5 100,704,447 (GRCm39) missense probably benign 0.07
R5213:Plac8 UTSW 5 100,704,371 (GRCm39) missense probably benign
R5522:Plac8 UTSW 5 100,710,584 (GRCm39) missense probably benign 0.06
R6735:Plac8 UTSW 5 100,710,485 (GRCm39) splice site probably null
X0024:Plac8 UTSW 5 100,707,706 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTGGTAAGTTGCTTCATTCATAGACC -3'
(R):5'- GGCTCTCCTTAAAATGCCCC -3'

Sequencing Primer
(F):5'- TCTGGTAAGTTTGTAAAATGTCACC -3'
(R):5'- GCTCTCCTTAAAATGCCCCAAAAAC -3'
Posted On 2016-07-22