Incidental Mutation 'IGL02875:Btg4'
ID 406191
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Btg4
Ensembl Gene ENSMUSG00000032056
Gene Name BTG anti-proliferation factor 4
Synonyms PC3B
Accession Numbers
Essential gene? Probably non essential (E-score: 0.242) question?
Stock # IGL02875
Quality Score
Status
Chromosome 9
Chromosomal Location 51013486-51031224 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 51030446 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 182 (F182Y)
Ref Sequence ENSEMBL: ENSMUSP00000149181 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114431] [ENSMUST00000213117] [ENSMUST00000213680] [ENSMUST00000214452]
AlphaFold O70552
Predicted Effect probably benign
Transcript: ENSMUST00000114431
AA Change: F182Y

PolyPhen 2 Score 0.170 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000110074
Gene: ENSMUSG00000032056
AA Change: F182Y

DomainStartEndE-ValueType
btg1 1 108 7.37e-64 SMART
low complexity region 138 153 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213117
Predicted Effect probably benign
Transcript: ENSMUST00000213680
AA Change: F182Y

PolyPhen 2 Score 0.170 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect probably benign
Transcript: ENSMUST00000214452
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T C 2: 69,122,293 (GRCm39) I397V possibly damaging Het
Asph A G 4: 9,595,380 (GRCm39) S281P probably damaging Het
Bdnf T C 2: 109,554,196 (GRCm39) V150A probably damaging Het
Birc6 T C 17: 74,896,713 (GRCm39) V1053A probably damaging Het
Casc3 T G 11: 98,712,378 (GRCm39) V139G probably damaging Het
Ccno C A 13: 113,124,586 (GRCm39) P52Q possibly damaging Het
Cdk1 T G 10: 69,178,366 (GRCm39) probably benign Het
Daam2 A C 17: 49,771,056 (GRCm39) I887S probably damaging Het
Dmrta1 A G 4: 89,579,985 (GRCm39) D315G possibly damaging Het
Dnah6 T C 6: 73,115,698 (GRCm39) I1515V probably damaging Het
Dock7 A T 4: 98,864,231 (GRCm39) I1241K probably benign Het
Fam180a T C 6: 35,290,617 (GRCm39) D122G probably damaging Het
Gm11992 C T 11: 9,002,887 (GRCm39) probably benign Het
Il1b A G 2: 129,209,171 (GRCm39) I153T probably benign Het
Kntc1 C A 5: 123,916,340 (GRCm39) probably null Het
Krt77 T C 15: 101,777,584 (GRCm39) D157G probably damaging Het
Lmbr1 A G 5: 29,497,186 (GRCm39) S72P probably damaging Het
Mphosph9 T A 5: 124,421,800 (GRCm39) probably null Het
Mpp4 C T 1: 59,175,993 (GRCm39) probably null Het
Ncbp2 T A 16: 31,772,971 (GRCm39) L36Q probably damaging Het
Or2b7 T A 13: 21,740,172 (GRCm39) S7C probably damaging Het
Or4a72 T C 2: 89,405,896 (GRCm39) Y58C probably damaging Het
Or8b3 A G 9: 38,314,472 (GRCm39) M101V probably damaging Het
Oscp1 A G 4: 125,970,601 (GRCm39) D130G probably damaging Het
Pls1 A T 9: 95,636,404 (GRCm39) M615K possibly damaging Het
Prep C A 10: 45,034,529 (GRCm39) H680Q probably damaging Het
Rad1 T C 15: 10,493,365 (GRCm39) I264T probably benign Het
Rhbdf1 A G 11: 32,163,293 (GRCm39) V393A possibly damaging Het
Skint3 A T 4: 112,113,079 (GRCm39) I230L possibly damaging Het
Slc9b1 T A 3: 135,080,167 (GRCm39) probably benign Het
Slfn3 T C 11: 83,104,253 (GRCm39) Y375H probably damaging Het
Ssrp1 T A 2: 84,871,264 (GRCm39) I257N probably damaging Het
Svep1 A G 4: 58,082,821 (GRCm39) probably benign Het
Tcl1b2 T C 12: 105,120,358 (GRCm39) *118Q probably null Het
Thsd7b A G 1: 129,879,130 (GRCm39) Y989C probably damaging Het
Trim58 C T 11: 58,531,292 (GRCm39) probably benign Het
Vmn2r42 T C 7: 8,197,852 (GRCm39) T256A probably benign Het
Other mutations in Btg4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1741:Btg4 UTSW 9 51,027,910 (GRCm39) missense probably benign 0.24
R1876:Btg4 UTSW 9 51,028,489 (GRCm39) missense probably damaging 1.00
R6794:Btg4 UTSW 9 51,030,651 (GRCm39) missense possibly damaging 0.72
R7384:Btg4 UTSW 9 51,030,413 (GRCm39) missense probably benign 0.13
R7606:Btg4 UTSW 9 51,029,307 (GRCm39) missense probably damaging 1.00
R7877:Btg4 UTSW 9 51,029,240 (GRCm39) missense probably benign 0.00
R8094:Btg4 UTSW 9 51,030,445 (GRCm39) missense probably benign 0.04
R8231:Btg4 UTSW 9 51,027,868 (GRCm39) missense possibly damaging 0.80
R9576:Btg4 UTSW 9 51,030,436 (GRCm39) missense probably damaging 0.96
R9594:Btg4 UTSW 9 51,030,560 (GRCm39) missense probably damaging 1.00
Z1176:Btg4 UTSW 9 51,030,475 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02