Incidental Mutation 'IGL02875:Cdk1'
ID 406207
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk1
Ensembl Gene ENSMUSG00000019942
Gene Name cyclin dependent kinase 1
Synonyms Cdc2, Cdc2a, p34
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02875
Quality Score
Status
Chromosome 10
Chromosomal Location 69170976-69188742 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to G at 69178366 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119085 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020099] [ENSMUST00000119827] [ENSMUST00000152448]
AlphaFold P11440
Predicted Effect probably benign
Transcript: ENSMUST00000020099
SMART Domains Protein: ENSMUSP00000020099
Gene: ENSMUSG00000019942

DomainStartEndE-ValueType
S_TKc 4 287 7.87e-104 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119827
SMART Domains Protein: ENSMUSP00000113184
Gene: ENSMUSG00000019942

DomainStartEndE-ValueType
S_TKc 4 287 7.87e-104 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123458
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124054
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129444
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149474
Predicted Effect probably benign
Transcript: ENSMUST00000152448
SMART Domains Protein: ENSMUSP00000119085
Gene: ENSMUSG00000019942

DomainStartEndE-ValueType
Pfam:Pkinase 4 200 8.7e-65 PFAM
Pfam:Pkinase_Tyr 5 200 6.9e-35 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a null allele die prior to E1.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 T C 2: 69,122,293 (GRCm39) I397V possibly damaging Het
Asph A G 4: 9,595,380 (GRCm39) S281P probably damaging Het
Bdnf T C 2: 109,554,196 (GRCm39) V150A probably damaging Het
Birc6 T C 17: 74,896,713 (GRCm39) V1053A probably damaging Het
Btg4 T A 9: 51,030,446 (GRCm39) F182Y probably benign Het
Casc3 T G 11: 98,712,378 (GRCm39) V139G probably damaging Het
Ccno C A 13: 113,124,586 (GRCm39) P52Q possibly damaging Het
Daam2 A C 17: 49,771,056 (GRCm39) I887S probably damaging Het
Dmrta1 A G 4: 89,579,985 (GRCm39) D315G possibly damaging Het
Dnah6 T C 6: 73,115,698 (GRCm39) I1515V probably damaging Het
Dock7 A T 4: 98,864,231 (GRCm39) I1241K probably benign Het
Fam180a T C 6: 35,290,617 (GRCm39) D122G probably damaging Het
Gm11992 C T 11: 9,002,887 (GRCm39) probably benign Het
Il1b A G 2: 129,209,171 (GRCm39) I153T probably benign Het
Kntc1 C A 5: 123,916,340 (GRCm39) probably null Het
Krt77 T C 15: 101,777,584 (GRCm39) D157G probably damaging Het
Lmbr1 A G 5: 29,497,186 (GRCm39) S72P probably damaging Het
Mphosph9 T A 5: 124,421,800 (GRCm39) probably null Het
Mpp4 C T 1: 59,175,993 (GRCm39) probably null Het
Ncbp2 T A 16: 31,772,971 (GRCm39) L36Q probably damaging Het
Or2b7 T A 13: 21,740,172 (GRCm39) S7C probably damaging Het
Or4a72 T C 2: 89,405,896 (GRCm39) Y58C probably damaging Het
Or8b3 A G 9: 38,314,472 (GRCm39) M101V probably damaging Het
Oscp1 A G 4: 125,970,601 (GRCm39) D130G probably damaging Het
Pls1 A T 9: 95,636,404 (GRCm39) M615K possibly damaging Het
Prep C A 10: 45,034,529 (GRCm39) H680Q probably damaging Het
Rad1 T C 15: 10,493,365 (GRCm39) I264T probably benign Het
Rhbdf1 A G 11: 32,163,293 (GRCm39) V393A possibly damaging Het
Skint3 A T 4: 112,113,079 (GRCm39) I230L possibly damaging Het
Slc9b1 T A 3: 135,080,167 (GRCm39) probably benign Het
Slfn3 T C 11: 83,104,253 (GRCm39) Y375H probably damaging Het
Ssrp1 T A 2: 84,871,264 (GRCm39) I257N probably damaging Het
Svep1 A G 4: 58,082,821 (GRCm39) probably benign Het
Tcl1b2 T C 12: 105,120,358 (GRCm39) *118Q probably null Het
Thsd7b A G 1: 129,879,130 (GRCm39) Y989C probably damaging Het
Trim58 C T 11: 58,531,292 (GRCm39) probably benign Het
Vmn2r42 T C 7: 8,197,852 (GRCm39) T256A probably benign Het
Other mutations in Cdk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02343:Cdk1 APN 10 69,176,331 (GRCm39) missense probably benign
IGL03295:Cdk1 APN 10 69,178,373 (GRCm39) missense possibly damaging 0.88
R0064:Cdk1 UTSW 10 69,180,907 (GRCm39) missense probably benign 0.34
R0064:Cdk1 UTSW 10 69,180,907 (GRCm39) missense probably benign 0.34
R0413:Cdk1 UTSW 10 69,180,929 (GRCm39) missense probably benign 0.00
R1635:Cdk1 UTSW 10 69,174,377 (GRCm39) missense probably damaging 1.00
R4173:Cdk1 UTSW 10 69,180,991 (GRCm39) missense probably benign 0.19
R5154:Cdk1 UTSW 10 69,176,298 (GRCm39) unclassified probably benign
R6847:Cdk1 UTSW 10 69,174,358 (GRCm39) missense probably benign
R8222:Cdk1 UTSW 10 69,176,426 (GRCm39) missense probably benign 0.00
R8755:Cdk1 UTSW 10 69,176,435 (GRCm39) missense probably benign 0.02
R9681:Cdk1 UTSW 10 69,178,449 (GRCm39) missense possibly damaging 0.89
RF023:Cdk1 UTSW 10 69,176,328 (GRCm39) missense possibly damaging 0.69
Posted On 2016-08-02