Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02975:Or7a41'

406314

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or7a41

Ensembl Gene

ENSMUSG00000060205

Gene Name

olfactory receptor family 7 subfamily A member 41

Synonyms

MOR139-3, Olfr57, GA_x6K02T2QGN0-2777431-2776472, IF12

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

IGL02975

Quality Score

Status

Chromosome

Chromosomal Location

78870557-78871636 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 78870867 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 79 (V79A)

Ref Sequence

ENSEMBL: ENSMUSP00000144814 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082244] [ENSMUST00000203906]

AlphaFold

Q8VGU7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000082244
AA Change: V79A

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000080872
Gene: ENSMUSG00000060205
AA Change: V79A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	308	2.2e-49	PFAM
Pfam:7tm_1	42	291	6e-28	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000203906
AA Change: V79A

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000144814
Gene: ENSMUSG00000060205
AA Change: V79A

Domain	Start	End	E-Value	Type
low complexity region	9	19	N/A	INTRINSIC
Pfam:7tm_4	32	308	2e-49	PFAM
Pfam:7tm_1	42	291	1.9e-23	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A930011G23Rik	T	C	5: 99,381,784 (GRCm39)	D326G	possibly damaging	Het
Abtb3	A	G	10: 85,467,207 (GRCm39)	I721V	probably benign	Het
Ago4	C	T	4: 126,406,312 (GRCm39)		probably null	Het
Ank	A	G	15: 27,467,087 (GRCm39)		probably benign	Het
Ankmy2	C	A	12: 36,243,773 (GRCm39)	S329R	possibly damaging	Het
Aox1	A	G	1: 58,107,550 (GRCm39)	E608G	probably damaging	Het
Car1	G	A	3: 14,842,882 (GRCm39)	L48F	probably benign	Het
Cct8	A	G	16: 87,283,118 (GRCm39)		probably benign	Het
Clasp1	A	T	1: 118,390,277 (GRCm39)	T154S	probably damaging	Het
Clca4a	A	C	3: 144,669,530 (GRCm39)	I340M	possibly damaging	Het
Cnksr3	C	T	10: 7,088,354 (GRCm39)		probably null	Het
Cntrob	T	C	11: 69,210,199 (GRCm39)	T265A	possibly damaging	Het
Ddx5	T	C	11: 106,672,711 (GRCm39)	I605V	probably benign	Het
Eif3i	A	G	4: 129,489,105 (GRCm39)	Y70H	probably damaging	Het
Epb41l5	T	C	1: 119,506,811 (GRCm39)		probably benign	Het
Fah	A	T	7: 84,250,287 (GRCm39)	S90T	probably benign	Het
Fat2	T	A	11: 55,161,020 (GRCm39)	M3237L	probably benign	Het
Fbxw8	A	G	5: 118,215,760 (GRCm39)	Y417H	probably benign	Het
Fmnl2	C	A	2: 52,991,494 (GRCm39)	F336L	probably benign	Het
Gli3	A	G	13: 15,899,153 (GRCm39)	R847G	probably damaging	Het
Gm17509	T	C	13: 117,357,308 (GRCm39)		probably benign	Het
Gm4846	T	A	1: 166,311,449 (GRCm39)	Y470F	possibly damaging	Het
Gm7461	T	C	8: 4,727,847 (GRCm39)		noncoding transcript	Het
Gpatch4	A	T	3: 87,961,743 (GRCm39)	N134I	possibly damaging	Het
Grina	A	G	15: 76,133,185 (GRCm39)	Y251C	probably damaging	Het
Gsn	A	G	2: 35,194,666 (GRCm39)	D654G	probably benign	Het
Hyal5	A	G	6: 24,891,451 (GRCm39)	T422A	probably benign	Het
Iars1	T	A	13: 49,858,325 (GRCm39)	I377N	probably damaging	Het
Ints3	A	T	3: 90,309,144 (GRCm39)		probably benign	Het
Kdm4b	G	A	17: 56,682,996 (GRCm39)		probably null	Het
Kyat1	A	G	2: 30,076,687 (GRCm39)	S276P	probably damaging	Het
Lrrc1	A	G	9: 77,359,929 (GRCm39)	C288R	probably damaging	Het
Mst1r	T	A	9: 107,790,379 (GRCm39)	M664K	probably benign	Het
Neb	A	T	2: 52,188,879 (GRCm39)	I817N	probably damaging	Het
Nudt6	C	A	3: 37,473,667 (GRCm39)	G18V	probably damaging	Het
Or10a49	G	A	7: 108,468,062 (GRCm39)	Q100*	probably null	Het
Or4k52	T	A	2: 111,611,266 (GRCm39)	Y200*	probably null	Het
Pde1c	A	G	6: 56,135,921 (GRCm39)	I341T	probably damaging	Het
Pgm5	T	C	19: 24,812,212 (GRCm39)	I107V	probably benign	Het
Pot1b	G	A	17: 55,969,454 (GRCm39)		probably benign	Het
Prkca	C	T	11: 108,231,503 (GRCm39)	W58*	probably null	Het
Slc12a9	T	C	5: 137,320,705 (GRCm39)	K555R	probably damaging	Het
Smoc2	A	T	17: 14,556,872 (GRCm39)	Q107L	probably damaging	Het
Sytl1	T	A	4: 132,988,343 (GRCm39)	R4S	probably benign	Het
Tbc1d4	A	G	14: 101,695,549 (GRCm39)	L963P	probably damaging	Het
Tfdp2	G	A	9: 96,199,989 (GRCm39)		probably benign	Het
Tmem63a	A	T	1: 180,788,640 (GRCm39)	M326L	probably benign	Het
Vmn2r66	A	G	7: 84,656,182 (GRCm39)	L278P	probably damaging	Het
Wtap	A	G	17: 13,202,398 (GRCm39)	V11A	possibly damaging	Het
Zcchc9	A	T	13: 91,954,172 (GRCm39)	S28T	possibly damaging	Het
Zfp12	C	T	5: 143,229,814 (GRCm39)		probably benign	Het

Other mutations in Or7a41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01347:Or7a41	APN	10	78,871,445 (GRCm39)	missense	probably benign	0.05
IGL02230:Or7a41	APN	10	78,870,876 (GRCm39)	missense	probably damaging	0.99
IGL02283:Or7a41	APN	10	78,871,379 (GRCm39)	missense	probably damaging	1.00
IGL02878:Or7a41	APN	10	78,871,392 (GRCm39)	missense	probably benign	0.23
IGL03259:Or7a41	APN	10	78,871,234 (GRCm39)	nonsense	probably null
R1366:Or7a41	UTSW	10	78,870,876 (GRCm39)	missense	probably damaging	1.00
R1438:Or7a41	UTSW	10	78,871,122 (GRCm39)	missense	possibly damaging	0.88
R1528:Or7a41	UTSW	10	78,871,398 (GRCm39)	missense	probably damaging	0.96
R1601:Or7a41	UTSW	10	78,871,338 (GRCm39)	missense	possibly damaging	0.56
R2032:Or7a41	UTSW	10	78,871,163 (GRCm39)	missense	possibly damaging	0.86
R2112:Or7a41	UTSW	10	78,871,248 (GRCm39)	missense	probably damaging	1.00
R2382:Or7a41	UTSW	10	78,870,968 (GRCm39)	missense	possibly damaging	0.52
R2967:Or7a41	UTSW	10	78,870,887 (GRCm39)	missense	probably damaging	1.00
R3773:Or7a41	UTSW	10	78,871,014 (GRCm39)	missense	possibly damaging	0.95
R3940:Or7a41	UTSW	10	78,871,038 (GRCm39)	missense	probably damaging	1.00
R4405:Or7a41	UTSW	10	78,871,244 (GRCm39)	missense	probably benign
R5944:Or7a41	UTSW	10	78,871,223 (GRCm39)	missense	probably benign	0.00
R6563:Or7a41	UTSW	10	78,871,051 (GRCm39)	missense	possibly damaging	0.67
R6614:Or7a41	UTSW	10	78,870,925 (GRCm39)	nonsense	probably null
R7181:Or7a41	UTSW	10	78,871,287 (GRCm39)	missense	probably damaging	0.98
R7639:Or7a41	UTSW	10	78,871,206 (GRCm39)	missense	probably damaging	0.99
R9427:Or7a41	UTSW	10	78,871,395 (GRCm39)	missense	probably damaging	0.99
R9508:Or7a41	UTSW	10	78,870,933 (GRCm39)	missense	probably damaging	1.00
R9652:Or7a41	UTSW	10	78,871,230 (GRCm39)	missense	probably benign	0.05
R9681:Or7a41	UTSW	10	78,871,577 (GRCm39)	missense	probably benign
R9767:Or7a41	UTSW	10	78,870,765 (GRCm39)	missense	possibly damaging	0.78

Posted On

2016-08-02