Incidental Mutation 'IGL02975:Tfdp2'
ID 406350
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tfdp2
Ensembl Gene ENSMUSG00000032411
Gene Name transcription factor Dp 2
Synonyms A330080J22Rik, DP3, DP-3, 1110029I05Rik, DP3
Accession Numbers
Essential gene? Probably essential (E-score: 0.950) question?
Stock # IGL02975
Quality Score
Status
Chromosome 9
Chromosomal Location 96078348-96205699 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) G to A at 96199989 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000034982] [ENSMUST00000165120] [ENSMUST00000165768] [ENSMUST00000179065] [ENSMUST00000179416] [ENSMUST00000185644] [ENSMUST00000188008] [ENSMUST00000189606] [ENSMUST00000188750]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000034982
AA Change: E375K
SMART Domains Protein: ENSMUSP00000034982
Gene: ENSMUSG00000032411
AA Change: E375K

DomainStartEndE-ValueType
Pfam:E2F_TDP 66 147 3.8e-29 PFAM
DP 154 298 1.69e-87 SMART
low complexity region 345 361 N/A INTRINSIC
low complexity region 371 385 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000165120
AA Change: E300K
SMART Domains Protein: ENSMUSP00000132934
Gene: ENSMUSG00000032411
AA Change: E300K

DomainStartEndE-ValueType
Pfam:E2F_TDP 1 72 3.2e-25 PFAM
DP 79 223 1.69e-87 SMART
low complexity region 270 286 N/A INTRINSIC
low complexity region 296 310 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000165768
AA Change: E376K
SMART Domains Protein: ENSMUSP00000128260
Gene: ENSMUSG00000032411
AA Change: E376K

DomainStartEndE-ValueType
E2F_TDP 66 148 1.39e-33 SMART
DP 155 299 1.69e-87 SMART
low complexity region 346 362 N/A INTRINSIC
low complexity region 372 386 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000179065
AA Change: E349K
SMART Domains Protein: ENSMUSP00000136817
Gene: ENSMUSG00000032411
AA Change: E349K

DomainStartEndE-ValueType
Pfam:E2F_TDP 40 121 3.9e-29 PFAM
DP 128 272 1.69e-87 SMART
low complexity region 319 335 N/A INTRINSIC
low complexity region 345 359 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000179416
AA Change: E375K
SMART Domains Protein: ENSMUSP00000137176
Gene: ENSMUSG00000032411
AA Change: E375K

DomainStartEndE-ValueType
Pfam:E2F_TDP 66 147 3.8e-29 PFAM
DP 154 298 1.69e-87 SMART
low complexity region 345 361 N/A INTRINSIC
low complexity region 371 385 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000185644
AA Change: E375K
SMART Domains Protein: ENSMUSP00000140061
Gene: ENSMUSG00000032411
AA Change: E375K

DomainStartEndE-ValueType
Pfam:E2F_TDP 66 147 3.8e-29 PFAM
DP 154 298 1.69e-87 SMART
low complexity region 345 361 N/A INTRINSIC
low complexity region 371 385 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000188008
AA Change: E360K
SMART Domains Protein: ENSMUSP00000139848
Gene: ENSMUSG00000032411
AA Change: E360K

DomainStartEndE-ValueType
Pfam:E2F_TDP 50 132 1e-26 PFAM
DP 139 283 8e-92 SMART
low complexity region 330 346 N/A INTRINSIC
low complexity region 356 365 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000189606
AA Change: E360K
SMART Domains Protein: ENSMUSP00000141084
Gene: ENSMUSG00000032411
AA Change: E360K

DomainStartEndE-ValueType
Pfam:E2F_TDP 50 132 1e-26 PFAM
DP 139 283 8e-92 SMART
low complexity region 330 346 N/A INTRINSIC
low complexity region 356 365 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000188750
AA Change: E436K
SMART Domains Protein: ENSMUSP00000139926
Gene: ENSMUSG00000032411
AA Change: E436K

DomainStartEndE-ValueType
Pfam:E2F_TDP 127 208 1.3e-26 PFAM
DP 215 359 8e-92 SMART
low complexity region 406 422 N/A INTRINSIC
low complexity region 432 446 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000191133
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Allele List at MGI

 All alleles(416) : Targeted, other(1) Gene trapped(415)

SNPs within 2kb(416 from dbSNP Build 128)  

Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik T C 5: 99,381,784 (GRCm39) D326G possibly damaging Het
Abtb3 A G 10: 85,467,207 (GRCm39) I721V probably benign Het
Ago4 C T 4: 126,406,312 (GRCm39) probably null Het
Ank A G 15: 27,467,087 (GRCm39) probably benign Het
Ankmy2 C A 12: 36,243,773 (GRCm39) S329R possibly damaging Het
Aox1 A G 1: 58,107,550 (GRCm39) E608G probably damaging Het
Car1 G A 3: 14,842,882 (GRCm39) L48F probably benign Het
Cct8 A G 16: 87,283,118 (GRCm39) probably benign Het
Clasp1 A T 1: 118,390,277 (GRCm39) T154S probably damaging Het
Clca4a A C 3: 144,669,530 (GRCm39) I340M possibly damaging Het
Cnksr3 C T 10: 7,088,354 (GRCm39) probably null Het
Cntrob T C 11: 69,210,199 (GRCm39) T265A possibly damaging Het
Ddx5 T C 11: 106,672,711 (GRCm39) I605V probably benign Het
Eif3i A G 4: 129,489,105 (GRCm39) Y70H probably damaging Het
Epb41l5 T C 1: 119,506,811 (GRCm39) probably benign Het
Fah A T 7: 84,250,287 (GRCm39) S90T probably benign Het
Fat2 T A 11: 55,161,020 (GRCm39) M3237L probably benign Het
Fbxw8 A G 5: 118,215,760 (GRCm39) Y417H probably benign Het
Fmnl2 C A 2: 52,991,494 (GRCm39) F336L probably benign Het
Gli3 A G 13: 15,899,153 (GRCm39) R847G probably damaging Het
Gm17509 T C 13: 117,357,308 (GRCm39) probably benign Het
Gm4846 T A 1: 166,311,449 (GRCm39) Y470F possibly damaging Het
Gm7461 T C 8: 4,727,847 (GRCm39) noncoding transcript Het
Gpatch4 A T 3: 87,961,743 (GRCm39) N134I possibly damaging Het
Grina A G 15: 76,133,185 (GRCm39) Y251C probably damaging Het
Gsn A G 2: 35,194,666 (GRCm39) D654G probably benign Het
Hyal5 A G 6: 24,891,451 (GRCm39) T422A probably benign Het
Iars1 T A 13: 49,858,325 (GRCm39) I377N probably damaging Het
Ints3 A T 3: 90,309,144 (GRCm39) probably benign Het
Kdm4b G A 17: 56,682,996 (GRCm39) probably null Het
Kyat1 A G 2: 30,076,687 (GRCm39) S276P probably damaging Het
Lrrc1 A G 9: 77,359,929 (GRCm39) C288R probably damaging Het
Mst1r T A 9: 107,790,379 (GRCm39) M664K probably benign Het
Neb A T 2: 52,188,879 (GRCm39) I817N probably damaging Het
Nudt6 C A 3: 37,473,667 (GRCm39) G18V probably damaging Het
Or10a49 G A 7: 108,468,062 (GRCm39) Q100* probably null Het
Or4k52 T A 2: 111,611,266 (GRCm39) Y200* probably null Het
Or7a41 T C 10: 78,870,867 (GRCm39) V79A possibly damaging Het
Pde1c A G 6: 56,135,921 (GRCm39) I341T probably damaging Het
Pgm5 T C 19: 24,812,212 (GRCm39) I107V probably benign Het
Pot1b G A 17: 55,969,454 (GRCm39) probably benign Het
Prkca C T 11: 108,231,503 (GRCm39) W58* probably null Het
Slc12a9 T C 5: 137,320,705 (GRCm39) K555R probably damaging Het
Smoc2 A T 17: 14,556,872 (GRCm39) Q107L probably damaging Het
Sytl1 T A 4: 132,988,343 (GRCm39) R4S probably benign Het
Tbc1d4 A G 14: 101,695,549 (GRCm39) L963P probably damaging Het
Tmem63a A T 1: 180,788,640 (GRCm39) M326L probably benign Het
Vmn2r66 A G 7: 84,656,182 (GRCm39) L278P probably damaging Het
Wtap A G 17: 13,202,398 (GRCm39) V11A possibly damaging Het
Zcchc9 A T 13: 91,954,172 (GRCm39) S28T possibly damaging Het
Zfp12 C T 5: 143,229,814 (GRCm39) probably benign Het
Other mutations in Tfdp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01566:Tfdp2 APN 9 96,177,083 (GRCm39) missense probably damaging 1.00
IGL01737:Tfdp2 APN 9 96,182,465 (GRCm39) missense possibly damaging 0.79
IGL02725:Tfdp2 APN 9 96,169,748 (GRCm39) missense possibly damaging 0.50
IGL02754:Tfdp2 APN 9 96,199,592 (GRCm39) missense probably benign 0.08
I2289:Tfdp2 UTSW 9 96,199,848 (GRCm39) nonsense probably null
R0329:Tfdp2 UTSW 9 96,188,946 (GRCm39) missense probably damaging 1.00
R0330:Tfdp2 UTSW 9 96,188,946 (GRCm39) missense probably damaging 1.00
R0478:Tfdp2 UTSW 9 96,172,636 (GRCm39) missense probably benign 0.01
R1843:Tfdp2 UTSW 9 96,199,857 (GRCm39) missense possibly damaging 0.90
R1851:Tfdp2 UTSW 9 96,179,762 (GRCm39) missense probably damaging 1.00
R2121:Tfdp2 UTSW 9 96,177,067 (GRCm39) missense probably damaging 1.00
R2432:Tfdp2 UTSW 9 96,192,643 (GRCm39) missense probably damaging 1.00
R4635:Tfdp2 UTSW 9 96,179,727 (GRCm39) missense probably damaging 1.00
R5970:Tfdp2 UTSW 9 96,199,627 (GRCm39) missense unknown
R7488:Tfdp2 UTSW 9 96,179,695 (GRCm39) missense probably damaging 1.00
R7905:Tfdp2 UTSW 9 96,192,659 (GRCm39) missense
R8222:Tfdp2 UTSW 9 96,192,666 (GRCm39) missense possibly damaging 0.59
R8986:Tfdp2 UTSW 9 96,172,637 (GRCm39) missense probably damaging 0.98
R9544:Tfdp2 UTSW 9 96,169,663 (GRCm39) missense probably damaging 1.00
R9588:Tfdp2 UTSW 9 96,169,663 (GRCm39) missense probably damaging 1.00
Z1177:Tfdp2 UTSW 9 96,188,911 (GRCm39) missense possibly damaging 0.96
Posted On 2016-08-02