Incidental Mutation 'IGL02976:Mocos'
ID 406380
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mocos
Ensembl Gene ENSMUSG00000039616
Gene Name molybdenum cofactor sulfurase
Synonyms 1110018O12Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # IGL02976
Quality Score
Status
Chromosome 18
Chromosomal Location 24786748-24834632 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24799626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 287 (K287E)
Ref Sequence ENSEMBL: ENSMUSP00000063609 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068006]
AlphaFold Q14CH1
Predicted Effect possibly damaging
Transcript: ENSMUST00000068006
AA Change: K287E

PolyPhen 2 Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000063609
Gene: ENSMUSG00000039616
AA Change: K287E

DomainStartEndE-ValueType
Pfam:Aminotran_5 50 481 7.5e-29 PFAM
Pfam:MOSC_N 569 689 1.1e-32 PFAM
Pfam:MOSC 715 853 3.7e-21 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH; MIM 607633) and aldehyde oxidase (AOX1; MIM 602841), which is required for their enzymatic activities (Ichida et al., 2001 [PubMed 11302742]).[supplied by OMIM, Feb 2010]
Allele List at MGI

All alleles(11) : Targeted(1) Gene trapped(10)

Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9630041A04Rik A G 9: 101,816,845 (GRCm39) T84A possibly damaging Het
Adgrd1 T A 5: 129,208,661 (GRCm39) S288T probably benign Het
Ano7 T A 1: 93,330,395 (GRCm39) D806E possibly damaging Het
Arl6 A G 16: 59,444,259 (GRCm39) L79P probably damaging Het
Card6 A T 15: 5,129,310 (GRCm39) C695* probably null Het
Carmil1 T C 13: 24,276,534 (GRCm39) N610S possibly damaging Het
Cdc40 A G 10: 40,758,917 (GRCm39) V52A probably benign Het
Chd4 G A 6: 125,098,331 (GRCm39) R369H probably damaging Het
Clasp2 C T 9: 113,735,204 (GRCm39) P1031L probably damaging Het
Cldn34d C T X: 75,626,690 (GRCm39) A121T probably benign Het
Clmp A C 9: 40,692,520 (GRCm39) Y263S possibly damaging Het
Cntn5 A G 9: 10,419,104 (GRCm39) probably benign Het
Folh1 A T 7: 86,412,126 (GRCm39) M215K probably benign Het
Fut1 C T 7: 45,268,744 (GRCm39) R233C probably damaging Het
Gcdh A C 8: 85,615,207 (GRCm39) Y398D probably damaging Het
Gm26741 T G 10: 52,234,910 (GRCm39) S16R possibly damaging Het
Jph3 T A 8: 122,479,823 (GRCm39) L167Q probably damaging Het
Jup A G 11: 100,269,192 (GRCm39) V407A probably benign Het
Kif17 C T 4: 137,996,374 (GRCm39) A117V probably damaging Het
Lyl1 C T 8: 85,429,300 (GRCm39) P3L possibly damaging Het
Magi2 C T 5: 20,739,473 (GRCm39) P349S probably damaging Het
Mlycd T C 8: 120,128,224 (GRCm39) M177T possibly damaging Het
Morc2b T A 17: 33,356,497 (GRCm39) H425L possibly damaging Het
Mrpl9 T A 3: 94,355,084 (GRCm39) probably benign Het
Myo3a G A 2: 22,434,494 (GRCm39) W825* probably null Het
Npas2 T C 1: 39,326,565 (GRCm39) S17P probably damaging Het
Nrk A G X: 137,892,817 (GRCm39) I1174V probably benign Het
Or1e32 A G 11: 73,705,143 (GRCm39) I255T probably damaging Het
Or4d11 A T 19: 12,013,337 (GRCm39) Y256* probably null Het
Or4k2 G A 14: 50,423,889 (GRCm39) Q262* probably null Het
Parpbp A G 10: 87,947,456 (GRCm39) probably null Het
Pcdh10 T C 3: 45,334,448 (GRCm39) V254A possibly damaging Het
Plod1 C T 4: 147,997,778 (GRCm39) V644I probably damaging Het
Ptpn1 T C 2: 167,813,704 (GRCm39) V149A probably benign Het
Rassf4 T C 6: 116,615,209 (GRCm39) E320G probably damaging Het
Rgl2 T A 17: 34,152,936 (GRCm39) D448E possibly damaging Het
Rnf32 C T 5: 29,411,710 (GRCm39) probably null Het
Rpa1 T A 11: 75,203,628 (GRCm39) D358V probably damaging Het
Sdk2 T C 11: 113,742,668 (GRCm39) N747S probably damaging Het
Slc17a4 A C 13: 24,089,407 (GRCm39) M170R probably damaging Het
Slc5a4a G A 10: 76,006,527 (GRCm39) V310M possibly damaging Het
Spag9 G A 11: 93,974,779 (GRCm39) R463H probably benign Het
Spmip5 A T 19: 58,777,552 (GRCm39) V78E probably benign Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Syt10 A G 15: 89,698,682 (GRCm39) S221P probably benign Het
Tlk1 T A 2: 70,551,935 (GRCm39) K579* probably null Het
Tubgcp3 T C 8: 12,682,300 (GRCm39) Y673C probably damaging Het
Vmn1r223 T C 13: 23,434,165 (GRCm39) F253S probably damaging Het
Vmn2r83 T C 10: 79,304,832 (GRCm39) M14T probably benign Het
Zfp59 A G 7: 27,552,821 (GRCm39) D91G probably benign Het
Other mutations in Mocos
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00310:Mocos APN 18 24,793,101 (GRCm39) missense possibly damaging 0.88
IGL01859:Mocos APN 18 24,799,717 (GRCm39) splice site probably benign
IGL01884:Mocos APN 18 24,816,273 (GRCm39) missense probably damaging 1.00
IGL02174:Mocos APN 18 24,828,953 (GRCm39) missense probably benign 0.00
IGL02966:Mocos APN 18 24,809,668 (GRCm39) missense probably damaging 1.00
buteo UTSW 18 24,799,467 (GRCm39) missense probably damaging 0.98
swainson UTSW 18 24,812,447 (GRCm39) missense probably damaging 1.00
P0008:Mocos UTSW 18 24,812,663 (GRCm39) missense probably benign 0.32
PIT4810001:Mocos UTSW 18 24,819,759 (GRCm39) missense probably damaging 1.00
R0131:Mocos UTSW 18 24,812,819 (GRCm39) missense probably benign 0.01
R0131:Mocos UTSW 18 24,812,819 (GRCm39) missense probably benign 0.01
R0132:Mocos UTSW 18 24,812,819 (GRCm39) missense probably benign 0.01
R0265:Mocos UTSW 18 24,799,333 (GRCm39) missense probably benign 0.01
R0737:Mocos UTSW 18 24,822,044 (GRCm39) missense probably damaging 0.98
R1231:Mocos UTSW 18 24,812,758 (GRCm39) missense probably benign 0.01
R1351:Mocos UTSW 18 24,793,107 (GRCm39) missense probably damaging 1.00
R1699:Mocos UTSW 18 24,816,273 (GRCm39) missense probably damaging 1.00
R1853:Mocos UTSW 18 24,829,026 (GRCm39) missense probably damaging 1.00
R2190:Mocos UTSW 18 24,797,114 (GRCm39) missense probably benign 0.01
R2350:Mocos UTSW 18 24,799,713 (GRCm39) splice site probably benign
R2680:Mocos UTSW 18 24,809,686 (GRCm39) missense probably damaging 1.00
R3840:Mocos UTSW 18 24,809,681 (GRCm39) missense probably damaging 1.00
R3841:Mocos UTSW 18 24,809,681 (GRCm39) missense probably damaging 1.00
R3847:Mocos UTSW 18 24,809,719 (GRCm39) missense probably damaging 0.99
R4059:Mocos UTSW 18 24,812,447 (GRCm39) missense probably damaging 1.00
R4158:Mocos UTSW 18 24,807,303 (GRCm39) missense probably damaging 0.99
R4205:Mocos UTSW 18 24,799,248 (GRCm39) missense possibly damaging 0.88
R4514:Mocos UTSW 18 24,816,269 (GRCm39) missense probably damaging 0.99
R4589:Mocos UTSW 18 24,787,095 (GRCm39) missense probably damaging 0.99
R4667:Mocos UTSW 18 24,799,491 (GRCm39) missense probably benign 0.11
R4668:Mocos UTSW 18 24,799,491 (GRCm39) missense probably benign 0.11
R5162:Mocos UTSW 18 24,787,109 (GRCm39) missense probably damaging 0.98
R5187:Mocos UTSW 18 24,825,611 (GRCm39) missense probably damaging 0.97
R5533:Mocos UTSW 18 24,807,357 (GRCm39) missense probably damaging 1.00
R5629:Mocos UTSW 18 24,797,142 (GRCm39) critical splice donor site probably null
R5661:Mocos UTSW 18 24,799,052 (GRCm39) splice site probably null
R5952:Mocos UTSW 18 24,834,444 (GRCm39) missense possibly damaging 0.91
R5987:Mocos UTSW 18 24,819,750 (GRCm39) missense probably damaging 1.00
R6173:Mocos UTSW 18 24,809,639 (GRCm39) missense probably benign 0.03
R6209:Mocos UTSW 18 24,799,672 (GRCm39) missense probably benign 0.41
R6376:Mocos UTSW 18 24,834,542 (GRCm39) missense possibly damaging 0.50
R6416:Mocos UTSW 18 24,834,513 (GRCm39) missense probably damaging 0.99
R6452:Mocos UTSW 18 24,828,998 (GRCm39) missense probably benign 0.02
R6520:Mocos UTSW 18 24,799,447 (GRCm39) missense probably benign 0.01
R6631:Mocos UTSW 18 24,832,988 (GRCm39) missense probably benign 0.03
R6669:Mocos UTSW 18 24,799,467 (GRCm39) missense probably damaging 0.98
R7114:Mocos UTSW 18 24,799,572 (GRCm39) missense probably damaging 1.00
R7366:Mocos UTSW 18 24,809,673 (GRCm39) missense probably damaging 1.00
R7690:Mocos UTSW 18 24,797,082 (GRCm39) missense probably damaging 1.00
R7955:Mocos UTSW 18 24,799,216 (GRCm39) missense probably damaging 1.00
R8458:Mocos UTSW 18 24,799,314 (GRCm39) missense probably benign 0.00
R8762:Mocos UTSW 18 24,812,554 (GRCm39) missense probably damaging 0.99
R9072:Mocos UTSW 18 24,797,089 (GRCm39) missense probably damaging 0.98
R9073:Mocos UTSW 18 24,797,089 (GRCm39) missense probably damaging 0.98
R9192:Mocos UTSW 18 24,812,594 (GRCm39) missense probably benign 0.00
R9781:Mocos UTSW 18 24,828,939 (GRCm39) missense probably benign 0.02
Z1176:Mocos UTSW 18 24,803,690 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02