Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02981:Zbtb6'

406539

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zbtb6

Ensembl Gene

ENSMUSG00000066798

Gene Name

zinc finger and BTB domain containing 6

Synonyms

Zfp482, A830092L04Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.202) question?

Stock #

IGL02981

Quality Score

Status

Chromosome

Chromosomal Location

37315512-37320931 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 37319176 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 251 (Q251*)

Ref Sequence

ENSEMBL: ENSMUSP00000108554 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053098] [ENSMUST00000067043] [ENSMUST00000112932]

AlphaFold

Q8K088

Predicted Effect

probably null
Transcript: ENSMUST00000053098
AA Change: Q251*

SMART Domains

Protein: ENSMUSP00000056100
Gene: ENSMUSG00000066798
AA Change: Q251*

Domain	Start	End	E-Value	Type
BTB	33	127	2.67e-16	SMART
Blast:BTB	161	196	1e-5	BLAST
ZnF_C2H2	300	322	7.15e-2	SMART
ZnF_C2H2	325	347	1.58e-3	SMART
ZnF_C2H2	353	375	3.63e-3	SMART
ZnF_C2H2	381	404	8.81e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000067043

SMART Domains

Protein: ENSMUSP00000070071
Gene: ENSMUSG00000050714

Domain	Start	End	E-Value	Type
BTB	33	127	4.38e-12	SMART
low complexity region	169	179	N/A	INTRINSIC
ZnF_C2H2	273	295	1.36e-2	SMART
ZnF_C2H2	298	320	1.4e-4	SMART
ZnF_C2H2	326	348	2.99e-4	SMART
ZnF_C2H2	354	377	2.09e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000112932
AA Change: Q251*

SMART Domains

Protein: ENSMUSP00000108554
Gene: ENSMUSG00000066798
AA Change: Q251*

Domain	Start	End	E-Value	Type
BTB	33	127	2.67e-16	SMART
Blast:BTB	161	196	1e-5	BLAST
ZnF_C2H2	300	322	7.15e-2	SMART
ZnF_C2H2	325	347	1.58e-3	SMART
ZnF_C2H2	353	375	3.63e-3	SMART
ZnF_C2H2	381	404	8.81e-2	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd12	A	G	2: 150,675,044 (GRCm39)	S392P	probably benign	Het
Adam23	G	A	1: 63,610,112 (GRCm39)	V705I	probably damaging	Het
Ank2	T	G	3: 126,728,211 (GRCm39)	D794A	possibly damaging	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Aqr	T	C	2: 113,965,305 (GRCm39)		probably benign	Het
Atp9b	A	G	18: 80,797,504 (GRCm39)	V857A	possibly damaging	Het
Banp	T	C	8: 122,705,303 (GRCm39)	Y58H	possibly damaging	Het
Cacna1e	T	A	1: 154,347,171 (GRCm39)	N999Y	probably benign	Het
Cd14	T	C	18: 36,859,532 (GRCm39)		probably benign	Het
Crmp1	T	C	5: 37,443,770 (GRCm39)	I447T	probably damaging	Het
Dip2a	A	G	10: 76,112,255 (GRCm39)	V1090A	possibly damaging	Het
Ep400	T	A	5: 110,903,969 (GRCm39)	H210L	possibly damaging	Het
Ep400	T	A	5: 110,839,476 (GRCm39)		probably benign	Het
Fam243	T	C	16: 92,117,757 (GRCm39)	N177S	probably benign	Het
Fbxw26	A	G	9: 109,573,862 (GRCm39)	F97L	probably benign	Het
Fut8	C	A	12: 77,521,812 (GRCm39)	P484T	probably damaging	Het
Golph3	A	G	15: 12,349,550 (GRCm39)	E190G	probably benign	Het
Hectd1	A	T	12: 51,815,670 (GRCm39)	D1472E	possibly damaging	Het
Hnrnpdl	T	C	5: 100,184,958 (GRCm39)	I298V	possibly damaging	Het
Jakmip2	C	A	18: 43,695,595 (GRCm39)		probably null	Het
Kcnj5	G	A	9: 32,233,877 (GRCm39)	T146I	probably damaging	Het
Lyst	T	G	13: 13,809,496 (GRCm39)	F389V	probably damaging	Het
Myo1b	A	G	1: 51,817,532 (GRCm39)	S577P	probably damaging	Het
Myo3b	T	C	2: 69,938,969 (GRCm39)	V114A	probably damaging	Het
Or10a2	C	A	7: 106,673,758 (GRCm39)	T241N	probably damaging	Het
Pappa2	C	T	1: 158,678,714 (GRCm39)	G901R	probably benign	Het
Patz1	T	C	11: 3,240,656 (GRCm39)	Y15H	probably damaging	Het
Pdp2	T	C	8: 105,320,267 (GRCm39)	W39R	probably benign	Het
Poc5	T	C	13: 96,538,265 (GRCm39)		probably null	Het
Pou3f1	A	G	4: 124,552,236 (GRCm39)	D246G	probably damaging	Het
Pramel5	T	A	4: 143,999,430 (GRCm39)	Y219F	probably benign	Het
Prrc2c	C	T	1: 162,532,748 (GRCm39)		probably benign	Het
Ptpn13	A	G	5: 103,676,670 (GRCm39)	K678E	probably damaging	Het
Rps2	T	C	17: 24,940,698 (GRCm39)	F271L	probably benign	Het
Serpina3k	C	A	12: 104,307,250 (GRCm39)	Q161K	probably benign	Het
Serpinb6b	A	G	13: 33,155,589 (GRCm39)	T101A	probably benign	Het
Tprkb	T	A	6: 85,904,861 (GRCm39)	D112E	probably benign	Het
Tubal3	A	G	13: 3,983,257 (GRCm39)	T346A	probably benign	Het
Vwde	A	G	6: 13,193,112 (GRCm39)	F409S	possibly damaging	Het

Other mutations in Zbtb6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01951:Zbtb6	APN	2	37,319,343 (GRCm39)	missense	probably benign	0.38
IGL03390:Zbtb6	APN	2	37,319,584 (GRCm39)	missense	probably damaging	1.00
R0164:Zbtb6	UTSW	2	37,319,600 (GRCm39)	nonsense	probably null
R0164:Zbtb6	UTSW	2	37,319,600 (GRCm39)	nonsense	probably null
R0470:Zbtb6	UTSW	2	37,319,505 (GRCm39)	missense	probably damaging	0.99
R1472:Zbtb6	UTSW	2	37,319,356 (GRCm39)	missense	probably benign
R1606:Zbtb6	UTSW	2	37,319,130 (GRCm39)	missense	probably benign	0.00
R1824:Zbtb6	UTSW	2	37,319,829 (GRCm39)	missense	probably damaging	1.00
R4594:Zbtb6	UTSW	2	37,319,054 (GRCm39)	missense	possibly damaging	0.71
R4838:Zbtb6	UTSW	2	37,318,728 (GRCm39)	nonsense	probably null
R5000:Zbtb6	UTSW	2	37,319,251 (GRCm39)	missense	probably benign
R5816:Zbtb6	UTSW	2	37,319,227 (GRCm39)	missense	probably benign	0.01
R6005:Zbtb6	UTSW	2	37,318,977 (GRCm39)	missense	probably damaging	1.00
R6152:Zbtb6	UTSW	2	37,319,255 (GRCm39)	missense	probably benign	0.18
R6390:Zbtb6	UTSW	2	37,318,690 (GRCm39)	missense	probably benign	0.01
R7657:Zbtb6	UTSW	2	37,319,087 (GRCm39)	missense	probably benign
R7866:Zbtb6	UTSW	2	37,319,577 (GRCm39)	missense	probably damaging	1.00
R8310:Zbtb6	UTSW	2	37,319,896 (GRCm39)	missense	probably benign	0.00
R8969:Zbtb6	UTSW	2	37,318,677 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02