Incidental Mutation 'IGL02985:Galr1'
ID 406698
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Galr1
Ensembl Gene ENSMUSG00000024553
Gene Name galanin receptor 1
Synonyms Galnr1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02985
Quality Score
Status
Chromosome 18
Chromosomal Location 82410621-82424902 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 82411855 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 337 (M337K)
Ref Sequence ENSEMBL: ENSMUSP00000066381 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065224]
AlphaFold P56479
Predicted Effect probably benign
Transcript: ENSMUST00000065224
AA Change: M337K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000066381
Gene: ENSMUSG00000024553
AA Change: M337K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srw 38 320 3e-8 PFAM
Pfam:7TM_GPCR_Srsx 44 317 1.5e-11 PFAM
Pfam:7tm_1 50 302 3.6e-56 PFAM
Pfam:7TM_GPCR_Srv 53 319 1.2e-7 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene does not appear to result in a phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actc1 T C 2: 113,878,641 (GRCm39) E318G probably damaging Het
Birc6 T C 17: 74,947,185 (GRCm39) V2968A probably benign Het
Bltp1 T C 3: 37,012,906 (GRCm39) L1862S probably damaging Het
Cfap91 T A 16: 38,118,634 (GRCm39) I722F probably damaging Het
Csgalnact1 A G 8: 68,913,695 (GRCm39) V170A probably benign Het
Dnaaf10 G A 11: 17,179,845 (GRCm39) G282E probably damaging Het
Dph1 A G 11: 75,074,419 (GRCm39) V131A possibly damaging Het
Gm14214 G T 2: 154,611,374 (GRCm39) T160N probably benign Het
Gpatch8 G T 11: 102,372,336 (GRCm39) H401N unknown Het
Higd1a A G 9: 121,681,596 (GRCm39) F20L probably benign Het
Hmcn1 A T 1: 150,547,668 (GRCm39) I2761K probably damaging Het
Hspg2 T A 4: 137,235,114 (GRCm39) Y83N probably damaging Het
Ilvbl C T 10: 78,414,901 (GRCm39) P255S probably benign Het
Kpna2 T C 11: 106,880,163 (GRCm39) Y495C probably benign Het
Krt36 G T 11: 99,994,005 (GRCm39) Q327K probably benign Het
Lrrc34 T C 3: 30,690,444 (GRCm39) M153V probably benign Het
Map9 A T 3: 82,267,209 (GRCm39) R30* probably null Het
Mcf2l A G 8: 13,013,239 (GRCm39) Y48C probably damaging Het
Mfsd13b T A 7: 120,599,395 (GRCm39) I397K probably damaging Het
Mpp7 C A 18: 7,461,637 (GRCm39) probably null Het
Mrgprx2 C T 7: 48,132,245 (GRCm39) C191Y probably damaging Het
Or4c58 A T 2: 89,674,684 (GRCm39) I211N possibly damaging Het
Pabpc4l A G 3: 46,401,017 (GRCm39) V209A possibly damaging Het
Pde7a T A 3: 19,365,047 (GRCm39) H40L probably damaging Het
Phactr3 T C 2: 177,817,250 (GRCm39) V22A probably benign Het
Plcl2 G T 17: 50,994,842 (GRCm39) E1104* probably null Het
Ppp2cb A G 8: 34,105,474 (GRCm39) probably benign Het
Prl3c1 A T 13: 27,383,370 (GRCm39) Y12F probably damaging Het
Prune2 T C 19: 16,993,723 (GRCm39) probably null Het
Rfesd T C 13: 76,156,331 (GRCm39) D25G probably damaging Het
Rxfp1 C A 3: 79,559,533 (GRCm39) M429I possibly damaging Het
Tmf1 A G 6: 97,153,770 (GRCm39) L101P probably damaging Het
Ube2d2b T C 5: 107,978,663 (GRCm39) S105P probably damaging Het
Zfp518a C T 19: 40,902,111 (GRCm39) T680I possibly damaging Het
Other mutations in Galr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01992:Galr1 APN 18 82,411,942 (GRCm39) missense probably damaging 1.00
IGL02047:Galr1 APN 18 82,424,118 (GRCm39) missense probably damaging 1.00
R0147:Galr1 UTSW 18 82,423,695 (GRCm39) missense probably benign 0.01
R0148:Galr1 UTSW 18 82,423,695 (GRCm39) missense probably benign 0.01
R0417:Galr1 UTSW 18 82,423,665 (GRCm39) missense probably damaging 1.00
R1080:Galr1 UTSW 18 82,423,632 (GRCm39) missense probably damaging 1.00
R1481:Galr1 UTSW 18 82,423,866 (GRCm39) missense possibly damaging 0.82
R2422:Galr1 UTSW 18 82,424,048 (GRCm39) missense probably damaging 1.00
R4896:Galr1 UTSW 18 82,412,065 (GRCm39) missense probably damaging 1.00
R5219:Galr1 UTSW 18 82,412,110 (GRCm39) missense probably damaging 1.00
R5272:Galr1 UTSW 18 82,423,761 (GRCm39) missense probably benign 0.06
R5506:Galr1 UTSW 18 82,423,989 (GRCm39) missense possibly damaging 0.95
R5870:Galr1 UTSW 18 82,424,197 (GRCm39) missense probably benign 0.00
R5900:Galr1 UTSW 18 82,411,982 (GRCm39) missense probably damaging 1.00
R7229:Galr1 UTSW 18 82,423,789 (GRCm39) missense probably damaging 1.00
R7408:Galr1 UTSW 18 82,411,990 (GRCm39) missense probably damaging 1.00
R7897:Galr1 UTSW 18 82,424,256 (GRCm39) missense probably benign 0.06
R8551:Galr1 UTSW 18 82,424,191 (GRCm39) missense probably benign 0.31
R8952:Galr1 UTSW 18 82,411,909 (GRCm39) missense probably damaging 0.99
R9632:Galr1 UTSW 18 82,424,103 (GRCm39) missense probably damaging 0.99
R9710:Galr1 UTSW 18 82,424,103 (GRCm39) missense probably damaging 0.99
R9801:Galr1 UTSW 18 82,423,912 (GRCm39) missense possibly damaging 0.77
Z1177:Galr1 UTSW 18 82,423,897 (GRCm39) missense probably benign
Posted On 2016-08-02