Incidental Mutation 'IGL02985:Ppp2cb'
ID 406700
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ppp2cb
Ensembl Gene ENSMUSG00000009630
Gene Name protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Synonyms PP2Ac, D8Ertd766e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02985
Quality Score
Status
Chromosome 8
Chromosomal Location 34089653-34109469 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 34105474 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000092992 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000009774] [ENSMUST00000095349]
AlphaFold P62715
Predicted Effect probably benign
Transcript: ENSMUST00000009774
SMART Domains Protein: ENSMUSP00000009774
Gene: ENSMUSG00000009630

DomainStartEndE-ValueType
PP2Ac 23 293 2.48e-156 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000095349
SMART Domains Protein: ENSMUSP00000092992
Gene: ENSMUSG00000052906

DomainStartEndE-ValueType
transmembrane domain 5 22 N/A INTRINSIC
transmembrane domain 34 56 N/A INTRINSIC
low complexity region 70 81 N/A INTRINSIC
Pfam:UBX 192 271 3.8e-16 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actc1 T C 2: 113,878,641 (GRCm39) E318G probably damaging Het
Birc6 T C 17: 74,947,185 (GRCm39) V2968A probably benign Het
Bltp1 T C 3: 37,012,906 (GRCm39) L1862S probably damaging Het
Cfap91 T A 16: 38,118,634 (GRCm39) I722F probably damaging Het
Csgalnact1 A G 8: 68,913,695 (GRCm39) V170A probably benign Het
Dnaaf10 G A 11: 17,179,845 (GRCm39) G282E probably damaging Het
Dph1 A G 11: 75,074,419 (GRCm39) V131A possibly damaging Het
Galr1 A T 18: 82,411,855 (GRCm39) M337K probably benign Het
Gm14214 G T 2: 154,611,374 (GRCm39) T160N probably benign Het
Gpatch8 G T 11: 102,372,336 (GRCm39) H401N unknown Het
Higd1a A G 9: 121,681,596 (GRCm39) F20L probably benign Het
Hmcn1 A T 1: 150,547,668 (GRCm39) I2761K probably damaging Het
Hspg2 T A 4: 137,235,114 (GRCm39) Y83N probably damaging Het
Ilvbl C T 10: 78,414,901 (GRCm39) P255S probably benign Het
Kpna2 T C 11: 106,880,163 (GRCm39) Y495C probably benign Het
Krt36 G T 11: 99,994,005 (GRCm39) Q327K probably benign Het
Lrrc34 T C 3: 30,690,444 (GRCm39) M153V probably benign Het
Map9 A T 3: 82,267,209 (GRCm39) R30* probably null Het
Mcf2l A G 8: 13,013,239 (GRCm39) Y48C probably damaging Het
Mfsd13b T A 7: 120,599,395 (GRCm39) I397K probably damaging Het
Mpp7 C A 18: 7,461,637 (GRCm39) probably null Het
Mrgprx2 C T 7: 48,132,245 (GRCm39) C191Y probably damaging Het
Or4c58 A T 2: 89,674,684 (GRCm39) I211N possibly damaging Het
Pabpc4l A G 3: 46,401,017 (GRCm39) V209A possibly damaging Het
Pde7a T A 3: 19,365,047 (GRCm39) H40L probably damaging Het
Phactr3 T C 2: 177,817,250 (GRCm39) V22A probably benign Het
Plcl2 G T 17: 50,994,842 (GRCm39) E1104* probably null Het
Prl3c1 A T 13: 27,383,370 (GRCm39) Y12F probably damaging Het
Prune2 T C 19: 16,993,723 (GRCm39) probably null Het
Rfesd T C 13: 76,156,331 (GRCm39) D25G probably damaging Het
Rxfp1 C A 3: 79,559,533 (GRCm39) M429I possibly damaging Het
Tmf1 A G 6: 97,153,770 (GRCm39) L101P probably damaging Het
Ube2d2b T C 5: 107,978,663 (GRCm39) S105P probably damaging Het
Zfp518a C T 19: 40,902,111 (GRCm39) T680I possibly damaging Het
Other mutations in Ppp2cb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01566:Ppp2cb APN 8 34,101,791 (GRCm39) missense probably benign 0.38
IGL03251:Ppp2cb APN 8 34,100,679 (GRCm39) splice site probably benign
Breakthrough UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R0940:Ppp2cb UTSW 8 34,105,689 (GRCm39) splice site probably null
R1688:Ppp2cb UTSW 8 34,105,480 (GRCm39) missense probably benign 0.02
R2187:Ppp2cb UTSW 8 34,100,705 (GRCm39) missense possibly damaging 0.95
R2350:Ppp2cb UTSW 8 34,101,855 (GRCm39) missense probably null 1.00
R4418:Ppp2cb UTSW 8 34,107,077 (GRCm39) missense probably benign
R4566:Ppp2cb UTSW 8 34,100,723 (GRCm39) missense possibly damaging 0.67
R6187:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably damaging 1.00
R6990:Ppp2cb UTSW 8 34,109,161 (GRCm39) missense probably benign 0.01
R7477:Ppp2cb UTSW 8 34,105,502 (GRCm39) missense probably benign 0.01
R9018:Ppp2cb UTSW 8 34,105,787 (GRCm39) missense probably benign 0.17
R9301:Ppp2cb UTSW 8 34,090,038 (GRCm39) missense possibly damaging 0.68
Posted On 2016-08-02