Incidental Mutation 'IGL02986:Zfp369'
ID406738
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp369
Ensembl Gene ENSMUSG00000021514
Gene Namezinc finger protein 369
SynonymsB930030B22Rik, NRIF2, D230020H11Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.189) question?
Stock #IGL02986
Quality Score
Status
Chromosome13
Chromosomal Location65278814-65304221 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 65280281 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Valine at position 18 (D18V)
Ref Sequence ENSEMBL: ENSMUSP00000119796 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000126879] [ENSMUST00000130799] [ENSMUST00000155732]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125510
Predicted Effect probably damaging
Transcript: ENSMUST00000126879
AA Change: D39V

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000119114
Gene: ENSMUSG00000021514
AA Change: D39V

DomainStartEndE-ValueType
KRAB 35 95 7.13e-20 SMART
SCAN 178 289 2.57e-39 SMART
KRAB 300 367 1.63e-14 SMART
low complexity region 440 452 N/A INTRINSIC
ZnF_C2H2 701 723 5.42e-2 SMART
ZnF_C2H2 729 751 4.79e-3 SMART
ZnF_C2H2 757 779 1.47e-3 SMART
ZnF_C2H2 785 807 2.43e-4 SMART
ZnF_C2H2 813 835 6.88e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000130799
AA Change: D39V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000116221
Gene: ENSMUSG00000021514
AA Change: D39V

DomainStartEndE-ValueType
KRAB 35 95 7.13e-20 SMART
SCAN 178 289 2.57e-39 SMART
KRAB 300 354 3.54e-15 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000155732
AA Change: D18V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000119796
Gene: ENSMUSG00000021514
AA Change: D18V

DomainStartEndE-ValueType
KRAB 14 70 1.36e-16 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn A G 4: 156,178,854 V264A possibly damaging Het
Akr1c6 G T 13: 4,436,415 V74L probably benign Het
Atp10a T G 7: 58,828,721 V1504G probably benign Het
Ccng1 A G 11: 40,750,863 probably benign Het
Celsr3 A T 9: 108,841,255 probably null Het
Coro1b T C 19: 4,149,471 V43A possibly damaging Het
Dab1 A G 4: 104,479,221 T5A probably benign Het
Dennd5a C T 7: 109,935,524 A47T probably benign Het
Dgkb A G 12: 38,100,400 T69A possibly damaging Het
Dhx37 G A 5: 125,419,315 P721L probably damaging Het
Efr3b T C 12: 3,966,495 N641D probably benign Het
Espnl A T 1: 91,344,850 Q600L probably benign Het
Esyt1 A G 10: 128,516,757 V693A probably damaging Het
Fscn2 A G 11: 120,367,350 D366G possibly damaging Het
Gcsam C A 16: 45,620,003 F136L probably benign Het
Gm10643 A T 8: 84,064,258 probably benign Het
Habp2 A T 19: 56,311,192 D174V probably benign Het
Hgfac T C 5: 35,043,863 V210A probably benign Het
Hipk3 T C 2: 104,433,741 D804G probably damaging Het
L3mbtl1 T C 2: 162,970,305 W757R probably damaging Het
Lrrfip2 A G 9: 111,161,393 probably null Het
Ly75 T C 2: 60,308,191 D1444G probably damaging Het
Mars A G 10: 127,297,569 V765A probably benign Het
Med1 A G 11: 98,156,260 probably benign Het
Msln G A 17: 25,752,933 probably benign Het
Nup188 T A 2: 30,307,633 probably null Het
Olfr406 T G 11: 74,270,102 F238V possibly damaging Het
Olfr866 A T 9: 20,027,711 F76I probably benign Het
Otop2 T A 11: 115,329,567 M411K probably benign Het
Picalm A G 7: 90,207,585 I649M probably benign Het
Plekha8 T C 6: 54,629,866 L382P probably damaging Het
Pspn A G 17: 56,999,853 probably benign Het
Rnf215 A G 11: 4,139,793 T269A probably damaging Het
Rps6kc1 A T 1: 190,834,061 L329Q probably damaging Het
Srms T A 2: 181,212,497 R92S possibly damaging Het
Ssxb10 C A X: 8,335,606 S157* probably null Het
Tfap2c T C 2: 172,557,251 S448P probably damaging Het
Thsd7b A G 1: 129,915,615 N855D probably benign Het
Timeless A C 10: 128,249,760 D887A possibly damaging Het
Tyms T C 5: 30,061,999 Y169C probably damaging Het
Unc45b T A 11: 82,917,179 C207S probably damaging Het
Utp20 A G 10: 88,775,285 F1390S probably damaging Het
Vmn2r53 A T 7: 12,581,466 probably benign Het
Other mutations in Zfp369
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00969:Zfp369 APN 13 65297260 missense probably benign 0.41
IGL01393:Zfp369 APN 13 65294474 missense possibly damaging 0.85
IGL02277:Zfp369 APN 13 65284932 missense probably damaging 1.00
IGL02992:Zfp369 APN 13 65294451 missense possibly damaging 0.50
IGL03170:Zfp369 APN 13 65294410 missense probably damaging 0.99
IGL03351:Zfp369 APN 13 65296153 missense possibly damaging 0.95
R0136:Zfp369 UTSW 13 65297202 missense probably benign 0.08
R0600:Zfp369 UTSW 13 65296434 missense probably damaging 0.97
R0646:Zfp369 UTSW 13 65297548 missense probably damaging 1.00
R1190:Zfp369 UTSW 13 65292293 missense probably damaging 0.99
R1191:Zfp369 UTSW 13 65291962 nonsense probably null
R1528:Zfp369 UTSW 13 65292165 missense probably damaging 1.00
R1934:Zfp369 UTSW 13 65297151 missense probably damaging 1.00
R2168:Zfp369 UTSW 13 65296948 missense probably benign 0.01
R4386:Zfp369 UTSW 13 65296992 missense probably benign 0.00
R4928:Zfp369 UTSW 13 65296800 missense possibly damaging 0.91
R5127:Zfp369 UTSW 13 65279033 start gained probably benign
R5549:Zfp369 UTSW 13 65297380 missense probably damaging 1.00
R5740:Zfp369 UTSW 13 65296767 missense probably benign
R5743:Zfp369 UTSW 13 65295680 missense probably benign 0.02
R5840:Zfp369 UTSW 13 65297278 missense possibly damaging 0.46
R6351:Zfp369 UTSW 13 65296230 missense possibly damaging 0.83
R7248:Zfp369 UTSW 13 65296117 missense probably damaging 0.98
R7288:Zfp369 UTSW 13 65285018 critical splice donor site probably null
R7314:Zfp369 UTSW 13 65292104 missense probably damaging 0.97
Posted On2016-08-02