Incidental Mutation 'IGL02986:Ccng1'
ID 406744
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccng1
Ensembl Gene ENSMUSG00000020326
Gene Name cyclin G1
Synonyms cyclin G
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # IGL02986
Quality Score
Status
Chromosome 11
Chromosomal Location 40639379-40646044 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) A to G at 40641690 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000020576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020576]
AlphaFold P51945
Predicted Effect probably benign
Transcript: ENSMUST00000020576
SMART Domains Protein: ENSMUSP00000020576
Gene: ENSMUSG00000020326

DomainStartEndE-ValueType
CYCLIN 56 142 3.63e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151359
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Depending on the allele, homozygous mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(4)

Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agrn A G 4: 156,263,311 (GRCm39) V264A possibly damaging Het
Akr1c6 G T 13: 4,486,414 (GRCm39) V74L probably benign Het
Atp10a T G 7: 58,478,469 (GRCm39) V1504G probably benign Het
Celsr3 A T 9: 108,718,454 (GRCm39) probably null Het
Coro1b T C 19: 4,199,470 (GRCm39) V43A possibly damaging Het
Dab1 A G 4: 104,336,418 (GRCm39) T5A probably benign Het
Dennd5a C T 7: 109,534,731 (GRCm39) A47T probably benign Het
Dgkb A G 12: 38,150,399 (GRCm39) T69A possibly damaging Het
Dhx37 G A 5: 125,496,379 (GRCm39) P721L probably damaging Het
Efr3b T C 12: 4,016,495 (GRCm39) N641D probably benign Het
Espnl A T 1: 91,272,572 (GRCm39) Q600L probably benign Het
Esyt1 A G 10: 128,352,626 (GRCm39) V693A probably damaging Het
Fscn2 A G 11: 120,258,176 (GRCm39) D366G possibly damaging Het
Gcsam C A 16: 45,440,366 (GRCm39) F136L probably benign Het
Gm10643 A T 8: 84,790,887 (GRCm39) probably benign Het
Habp2 A T 19: 56,299,624 (GRCm39) D174V probably benign Het
Hgfac T C 5: 35,201,207 (GRCm39) V210A probably benign Het
Hipk3 T C 2: 104,264,086 (GRCm39) D804G probably damaging Het
L3mbtl1 T C 2: 162,812,225 (GRCm39) W757R probably damaging Het
Lrrfip2 A G 9: 110,990,461 (GRCm39) probably null Het
Ly75 T C 2: 60,138,535 (GRCm39) D1444G probably damaging Het
Mars1 A G 10: 127,133,438 (GRCm39) V765A probably benign Het
Med1 A G 11: 98,047,086 (GRCm39) probably benign Het
Msln G A 17: 25,971,907 (GRCm39) probably benign Het
Nup188 T A 2: 30,197,645 (GRCm39) probably null Het
Or1p1c T G 11: 74,160,928 (GRCm39) F238V possibly damaging Het
Or7e173 A T 9: 19,939,007 (GRCm39) F76I probably benign Het
Otop2 T A 11: 115,220,393 (GRCm39) M411K probably benign Het
Picalm A G 7: 89,856,793 (GRCm39) I649M probably benign Het
Plekha8 T C 6: 54,606,851 (GRCm39) L382P probably damaging Het
Pspn A G 17: 57,306,853 (GRCm39) probably benign Het
Rnf215 A G 11: 4,089,793 (GRCm39) T269A probably damaging Het
Rps6kc1 A T 1: 190,566,258 (GRCm39) L329Q probably damaging Het
Srms T A 2: 180,854,290 (GRCm39) R92S possibly damaging Het
Ssxb10 C A X: 8,201,845 (GRCm39) S157* probably null Het
Tfap2c T C 2: 172,399,171 (GRCm39) S448P probably damaging Het
Thsd7b A G 1: 129,843,352 (GRCm39) N855D probably benign Het
Timeless A C 10: 128,085,629 (GRCm39) D887A possibly damaging Het
Tyms T C 5: 30,266,997 (GRCm39) Y169C probably damaging Het
Unc45b T A 11: 82,808,005 (GRCm39) C207S probably damaging Het
Utp20 A G 10: 88,611,147 (GRCm39) F1390S probably damaging Het
Vmn2r53 A T 7: 12,315,393 (GRCm39) probably benign Het
Zfp369 A T 13: 65,428,095 (GRCm39) D18V probably damaging Het
Other mutations in Ccng1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Ccng1 APN 11 40,644,885 (GRCm39) missense probably benign 0.00
IGL01875:Ccng1 APN 11 40,643,183 (GRCm39) missense probably benign 0.09
G5030:Ccng1 UTSW 11 40,644,629 (GRCm39) splice site probably benign
R1375:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1377:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1715:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R3620:Ccng1 UTSW 11 40,642,992 (GRCm39) missense probably benign 0.01
R3857:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R3858:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R5082:Ccng1 UTSW 11 40,643,015 (GRCm39) missense possibly damaging 0.77
R5172:Ccng1 UTSW 11 40,642,113 (GRCm39) missense probably benign
R5521:Ccng1 UTSW 11 40,643,093 (GRCm39) missense possibly damaging 0.87
R7431:Ccng1 UTSW 11 40,644,745 (GRCm39) missense possibly damaging 0.74
R7961:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8009:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8794:Ccng1 UTSW 11 40,644,826 (GRCm39) missense probably benign
R9036:Ccng1 UTSW 11 40,643,078 (GRCm39) missense possibly damaging 0.55
R9530:Ccng1 UTSW 11 40,644,885 (GRCm39) missense probably benign 0.00
T0975:Ccng1 UTSW 11 40,644,871 (GRCm39) missense probably benign
Posted On 2016-08-02