Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02987:Tet3'

406749

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tet3

Ensembl Gene

ENSMUSG00000034832

Gene Name

tet methylcytosine dioxygenase 3

Synonyms

B430006D22Rik, D230004J03Rik

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.640) question?

Stock #

IGL02987

Quality Score

Status

Chromosome

Chromosomal Location

83339355-83434190 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 83345074 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 1788 (S1788T)

Ref Sequence

ENSEMBL: ENSMUSP00000139630 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089622] [ENSMUST00000186548]

AlphaFold

Q8BG87

Predicted Effect

probably damaging
Transcript: ENSMUST00000089622
AA Change: S1653T

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000087049
Gene: ENSMUSG00000034832
AA Change: S1653T

Domain	Start	End	E-Value	Type
low complexity region	27	38	N/A	INTRINSIC
low complexity region	66	77	N/A	INTRINSIC
low complexity region	115	126	N/A	INTRINSIC
internal_repeat_1	160	277	4.9e-5	PROSPERO
low complexity region	279	297	N/A	INTRINSIC
low complexity region	359	371	N/A	INTRINSIC
low complexity region	418	456	N/A	INTRINSIC
Tet_JBP	858	1570	N/A	SMART
coiled coil region	1579	1603	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000186548
AA Change: S1788T

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000139630
Gene: ENSMUSG00000034832
AA Change: S1788T

Domain	Start	End	E-Value	Type
Pfam:zf-CXXC	49	89	8e-6	PFAM
low complexity region	162	173	N/A	INTRINSIC
low complexity region	201	212	N/A	INTRINSIC
low complexity region	250	261	N/A	INTRINSIC
internal_repeat_1	295	412	5.5e-5	PROSPERO
low complexity region	414	432	N/A	INTRINSIC
low complexity region	494	506	N/A	INTRINSIC
low complexity region	553	591	N/A	INTRINSIC
Tet_JBP	993	1705	N/A	SMART
coiled coil region	1714	1738	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]
PHENOTYPE: Mice inheriting a null allele from a germ cell conditional null mother display impaired reprogramming of the paternal genome resulting in reduced embryo viability. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1e1	T	C	13: 4,643,591 (GRCm39)	D222G	probably damaging	Het
Apbb1ip	T	A	2: 22,757,649 (GRCm39)	Y422*	probably null	Het
Asf1a	T	C	10: 53,473,367 (GRCm39)	F28L	probably damaging	Het
Atp6v1c1	T	A	15: 38,690,806 (GRCm39)	M319K	possibly damaging	Het
Bsn	A	G	9: 108,003,503 (GRCm39)	S301P	probably benign	Het
Cds1	A	G	5: 101,960,391 (GRCm39)	I281V	possibly damaging	Het
Col4a4	T	C	1: 82,476,646 (GRCm39)		probably benign	Het
Coq2	G	A	5: 100,811,554 (GRCm39)	Q103*	probably null	Het
Dgkh	A	G	14: 78,827,312 (GRCm39)		probably null	Het
Dnah9	A	G	11: 65,746,098 (GRCm39)	I4005T	probably damaging	Het
Dnah9	C	A	11: 65,732,099 (GRCm39)	R4269L	probably benign	Het
F2rl1	T	A	13: 95,650,741 (GRCm39)	Q47L	probably benign	Het
Fhod3	T	C	18: 25,246,610 (GRCm39)	V1272A	possibly damaging	Het
Gdpd4	T	C	7: 97,610,758 (GRCm39)		probably benign	Het
Gfral	A	G	9: 76,104,583 (GRCm39)	V143A	possibly damaging	Het
Gltp	A	C	5: 114,812,243 (GRCm39)	F88V	probably benign	Het
Hectd1	T	G	12: 51,791,550 (GRCm39)	K2565T	probably damaging	Het
Jade2	A	G	11: 51,721,308 (GRCm39)	S207P	probably damaging	Het
Khdc3	A	G	9: 73,009,948 (GRCm39)	I53V	possibly damaging	Het
Lce1a1	T	C	3: 92,554,409 (GRCm39)	T22A	unknown	Het
Lgals9	A	T	11: 78,858,303 (GRCm39)	H196Q	possibly damaging	Het
Lrrc37a	A	T	11: 103,391,239 (GRCm39)	N1395K	probably benign	Het
Mast1	C	T	8: 85,652,348 (GRCm39)	V268I	possibly damaging	Het
Myh11	T	G	16: 14,050,396 (GRCm39)	E523A	probably damaging	Het
Napb	T	C	2: 148,539,431 (GRCm39)		probably null	Het
Nlrp4e	G	A	7: 23,000,858 (GRCm39)	R51H	probably damaging	Het
Ola1	T	C	2: 72,987,242 (GRCm39)	D130G	probably benign	Het
Or8c13	A	T	9: 38,091,919 (GRCm39)	S67T	possibly damaging	Het
Pard3	G	A	8: 128,115,972 (GRCm39)	C687Y	probably damaging	Het
Rassf9	A	G	10: 102,381,109 (GRCm39)	T164A	possibly damaging	Het
Sema3a	A	G	5: 13,615,863 (GRCm39)	Y429C	probably damaging	Het
Slc25a54	T	C	3: 109,023,653 (GRCm39)	V416A	probably benign	Het
Slc30a5	T	C	13: 100,940,423 (GRCm39)	T631A	probably damaging	Het
Sorl1	A	T	9: 41,952,349 (GRCm39)	C736S	probably damaging	Het
Trim42	A	G	9: 97,247,868 (GRCm39)	V276A	probably benign	Het

Other mutations in Tet3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00929:Tet3	APN	6	83,345,637 (GRCm39)	missense	probably benign	0.06
IGL01396:Tet3	APN	6	83,346,620 (GRCm39)	nonsense	probably null
IGL02344:Tet3	APN	6	83,380,815 (GRCm39)	missense	probably benign	0.04
IGL03126:Tet3	APN	6	83,353,769 (GRCm39)	missense	probably damaging	1.00
IGL03155:Tet3	APN	6	83,345,365 (GRCm39)	missense	probably damaging	1.00
IGL03286:Tet3	APN	6	83,352,760 (GRCm39)	missense	probably damaging	1.00
Reedy	UTSW	6	83,345,066 (GRCm39)	nonsense	probably null
P0033:Tet3	UTSW	6	83,345,494 (GRCm39)	missense	probably damaging	1.00
R0131:Tet3	UTSW	6	83,345,770 (GRCm39)	missense	probably damaging	1.00
R0295:Tet3	UTSW	6	83,346,121 (GRCm39)	missense	probably benign	0.14
R0504:Tet3	UTSW	6	83,350,776 (GRCm39)	missense	probably damaging	1.00
R0524:Tet3	UTSW	6	83,356,924 (GRCm39)	missense	probably damaging	1.00
R1061:Tet3	UTSW	6	83,350,305 (GRCm39)	missense	probably damaging	0.99
R1160:Tet3	UTSW	6	83,381,434 (GRCm39)	missense	probably benign	0.00
R1550:Tet3	UTSW	6	83,363,010 (GRCm39)	missense	probably damaging	0.97
R1640:Tet3	UTSW	6	83,346,297 (GRCm39)	missense	probably benign	0.44
R1658:Tet3	UTSW	6	83,346,039 (GRCm39)	missense	probably benign	0.44
R1746:Tet3	UTSW	6	83,345,050 (GRCm39)	missense	probably damaging	1.00
R1761:Tet3	UTSW	6	83,380,641 (GRCm39)	missense	probably damaging	0.99
R1832:Tet3	UTSW	6	83,380,627 (GRCm39)	missense	probably benign
R1835:Tet3	UTSW	6	83,381,145 (GRCm39)	missense	possibly damaging	0.95
R1932:Tet3	UTSW	6	83,381,361 (GRCm39)	missense	possibly damaging	0.94
R2014:Tet3	UTSW	6	83,363,057 (GRCm39)	missense	probably damaging	1.00
R2230:Tet3	UTSW	6	83,346,453 (GRCm39)	missense	probably damaging	1.00
R2232:Tet3	UTSW	6	83,346,453 (GRCm39)	missense	probably damaging	1.00
R2922:Tet3	UTSW	6	83,345,494 (GRCm39)	missense	probably damaging	1.00
R3429:Tet3	UTSW	6	83,380,401 (GRCm39)	missense	probably damaging	1.00
R3430:Tet3	UTSW	6	83,380,401 (GRCm39)	missense	probably damaging	1.00
R4291:Tet3	UTSW	6	83,350,181 (GRCm39)	missense	probably damaging	1.00
R4349:Tet3	UTSW	6	83,380,257 (GRCm39)	missense	probably benign
R4809:Tet3	UTSW	6	83,379,928 (GRCm39)	missense	probably benign
R4846:Tet3	UTSW	6	83,353,865 (GRCm39)	nonsense	probably null
R5039:Tet3	UTSW	6	83,352,878 (GRCm39)	missense	probably damaging	1.00
R5233:Tet3	UTSW	6	83,363,045 (GRCm39)	missense	probably damaging	1.00
R5363:Tet3	UTSW	6	83,353,746 (GRCm39)	critical splice donor site	probably null
R5880:Tet3	UTSW	6	83,347,532 (GRCm39)	missense	probably damaging	1.00
R6270:Tet3	UTSW	6	83,352,773 (GRCm39)	missense	possibly damaging	0.86
R6277:Tet3	UTSW	6	83,345,066 (GRCm39)	nonsense	probably null
R6564:Tet3	UTSW	6	83,363,052 (GRCm39)	missense	possibly damaging	0.92
R6622:Tet3	UTSW	6	83,380,426 (GRCm39)	missense	probably benign	0.00
R7089:Tet3	UTSW	6	83,432,006 (GRCm39)	missense	possibly damaging	0.46
R7244:Tet3	UTSW	6	83,347,603 (GRCm39)	missense	probably damaging	1.00
R7251:Tet3	UTSW	6	83,381,038 (GRCm39)	missense	probably benign
R7361:Tet3	UTSW	6	83,345,076 (GRCm39)	missense	probably benign	0.15
R7436:Tet3	UTSW	6	83,345,211 (GRCm39)	small insertion	probably benign
R7438:Tet3	UTSW	6	83,345,211 (GRCm39)	small insertion	probably benign
R7544:Tet3	UTSW	6	83,381,623 (GRCm39)	missense	probably damaging	1.00
R7552:Tet3	UTSW	6	83,345,289 (GRCm39)	missense	probably damaging	1.00
R7942:Tet3	UTSW	6	83,353,956 (GRCm39)	missense	probably damaging	1.00
R8010:Tet3	UTSW	6	83,380,228 (GRCm39)	missense	unknown
R8063:Tet3	UTSW	6	83,379,723 (GRCm39)	missense	probably damaging	1.00
R8307:Tet3	UTSW	6	83,356,909 (GRCm39)	missense	probably damaging	1.00
R9016:Tet3	UTSW	6	83,345,253 (GRCm39)	missense	probably damaging	1.00
R9020:Tet3	UTSW	6	83,381,418 (GRCm39)	missense	probably damaging	1.00
R9377:Tet3	UTSW	6	83,380,596 (GRCm39)	missense	possibly damaging	0.95
R9476:Tet3	UTSW	6	83,381,808 (GRCm39)	critical splice acceptor site	probably null
R9476:Tet3	UTSW	6	83,380,935 (GRCm39)	missense	possibly damaging	0.91
R9510:Tet3	UTSW	6	83,381,808 (GRCm39)	critical splice acceptor site	probably null
R9510:Tet3	UTSW	6	83,380,935 (GRCm39)	missense	possibly damaging	0.91
R9582:Tet3	UTSW	6	83,381,226 (GRCm39)	missense	probably damaging	0.99
R9671:Tet3	UTSW	6	83,381,136 (GRCm39)	missense	possibly damaging	0.89
R9801:Tet3	UTSW	6	83,346,436 (GRCm39)	missense	possibly damaging	0.94
X0004:Tet3	UTSW	6	83,380,405 (GRCm39)	missense	probably benign	0.17
Z1176:Tet3	UTSW	6	83,436,003 (GRCm39)	missense	unknown
Z1176:Tet3	UTSW	6	83,381,332 (GRCm39)	missense	probably damaging	1.00
Z1176:Tet3	UTSW	6	83,347,680 (GRCm39)	missense	probably damaging	1.00
Z1177:Tet3	UTSW	6	83,381,276 (GRCm39)	missense	possibly damaging	0.62

Posted On

2016-08-02