Incidental Mutation 'IGL02987:Asf1a'
ID 406756
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Asf1a
Ensembl Gene ENSMUSG00000019857
Gene Name anti-silencing function 1A histone chaperone
Synonyms 2310079C17Rik
Accession Numbers
Essential gene? Not available question?
Stock # IGL02987
Quality Score
Status
Chromosome 10
Chromosomal Location 53473057-53485321 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 53473367 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 28 (F28L)
Ref Sequence ENSEMBL: ENSMUSP00000020004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020004] [ENSMUST00000075540] [ENSMUST00000219271] [ENSMUST00000219282] [ENSMUST00000220007] [ENSMUST00000219547]
AlphaFold Q9CQE6
Predicted Effect probably damaging
Transcript: ENSMUST00000020004
AA Change: F28L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000020004
Gene: ENSMUSG00000019857
AA Change: F28L

DomainStartEndE-ValueType
Pfam:ASF1_hist_chap 1 154 7.1e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000075540
SMART Domains Protein: ENSMUSP00000074978
Gene: ENSMUSG00000058298

DomainStartEndE-ValueType
low complexity region 22 44 N/A INTRINSIC
low complexity region 62 79 N/A INTRINSIC
low complexity region 81 111 N/A INTRINSIC
MCM 268 761 9.44e-116 SMART
AAA 500 649 2.43e-6 SMART
coiled coil region 789 817 N/A INTRINSIC
low complexity region 884 895 N/A INTRINSIC
low complexity region 1004 1028 N/A INTRINSIC
low complexity region 1045 1056 N/A INTRINSIC
low complexity region 1199 1216 N/A INTRINSIC
low complexity region 1219 1232 N/A INTRINSIC
low complexity region 1246 1255 N/A INTRINSIC
low complexity region 1262 1276 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218043
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218476
Predicted Effect probably benign
Transcript: ENSMUST00000219271
Predicted Effect probably benign
Transcript: ENSMUST00000219282
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219533
Predicted Effect probably benign
Transcript: ENSMUST00000220007
Predicted Effect probably benign
Transcript: ENSMUST00000219547
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220260
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele die at midgestation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akr1e1 T C 13: 4,643,591 (GRCm39) D222G probably damaging Het
Apbb1ip T A 2: 22,757,649 (GRCm39) Y422* probably null Het
Atp6v1c1 T A 15: 38,690,806 (GRCm39) M319K possibly damaging Het
Bsn A G 9: 108,003,503 (GRCm39) S301P probably benign Het
Cds1 A G 5: 101,960,391 (GRCm39) I281V possibly damaging Het
Col4a4 T C 1: 82,476,646 (GRCm39) probably benign Het
Coq2 G A 5: 100,811,554 (GRCm39) Q103* probably null Het
Dgkh A G 14: 78,827,312 (GRCm39) probably null Het
Dnah9 A G 11: 65,746,098 (GRCm39) I4005T probably damaging Het
Dnah9 C A 11: 65,732,099 (GRCm39) R4269L probably benign Het
F2rl1 T A 13: 95,650,741 (GRCm39) Q47L probably benign Het
Fhod3 T C 18: 25,246,610 (GRCm39) V1272A possibly damaging Het
Gdpd4 T C 7: 97,610,758 (GRCm39) probably benign Het
Gfral A G 9: 76,104,583 (GRCm39) V143A possibly damaging Het
Gltp A C 5: 114,812,243 (GRCm39) F88V probably benign Het
Hectd1 T G 12: 51,791,550 (GRCm39) K2565T probably damaging Het
Jade2 A G 11: 51,721,308 (GRCm39) S207P probably damaging Het
Khdc3 A G 9: 73,009,948 (GRCm39) I53V possibly damaging Het
Lce1a1 T C 3: 92,554,409 (GRCm39) T22A unknown Het
Lgals9 A T 11: 78,858,303 (GRCm39) H196Q possibly damaging Het
Lrrc37a A T 11: 103,391,239 (GRCm39) N1395K probably benign Het
Mast1 C T 8: 85,652,348 (GRCm39) V268I possibly damaging Het
Myh11 T G 16: 14,050,396 (GRCm39) E523A probably damaging Het
Napb T C 2: 148,539,431 (GRCm39) probably null Het
Nlrp4e G A 7: 23,000,858 (GRCm39) R51H probably damaging Het
Ola1 T C 2: 72,987,242 (GRCm39) D130G probably benign Het
Or8c13 A T 9: 38,091,919 (GRCm39) S67T possibly damaging Het
Pard3 G A 8: 128,115,972 (GRCm39) C687Y probably damaging Het
Rassf9 A G 10: 102,381,109 (GRCm39) T164A possibly damaging Het
Sema3a A G 5: 13,615,863 (GRCm39) Y429C probably damaging Het
Slc25a54 T C 3: 109,023,653 (GRCm39) V416A probably benign Het
Slc30a5 T C 13: 100,940,423 (GRCm39) T631A probably damaging Het
Sorl1 A T 9: 41,952,349 (GRCm39) C736S probably damaging Het
Tet3 A T 6: 83,345,074 (GRCm39) S1788T probably damaging Het
Trim42 A G 9: 97,247,868 (GRCm39) V276A probably benign Het
Other mutations in Asf1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00538:Asf1a APN 10 53,482,227 (GRCm39) missense probably damaging 1.00
IGL02156:Asf1a APN 10 53,482,239 (GRCm39) missense probably benign 0.25
IGL02819:Asf1a APN 10 53,483,920 (GRCm39) missense probably benign
R5499:Asf1a UTSW 10 53,482,266 (GRCm39) missense probably damaging 1.00
R7562:Asf1a UTSW 10 53,482,283 (GRCm39) nonsense probably null
Posted On 2016-08-02