Incidental Mutation 'IGL02992:Dpp7'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpp7
Ensembl Gene ENSMUSG00000026958
Gene Namedipeptidylpeptidase 7
Accession Numbers

Genbank: NM_031843.2; Ensembl: ENSMUST00000028332

Is this an essential gene? Probably non essential (E-score: 0.091) question?
Stock #IGL02992
Quality Score
Chromosomal Location25352276-25356359 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 25354577 bp
Amino Acid Change Aspartic acid to Glycine at position 264 (D264G)
Ref Sequence ENSEMBL: ENSMUSP00000028332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028332] [ENSMUST00000042390]
Predicted Effect possibly damaging
Transcript: ENSMUST00000028332
AA Change: D264G

PolyPhen 2 Score 0.648 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000028332
Gene: ENSMUSG00000026958
AA Change: D264G

signal peptide 1 33 N/A INTRINSIC
Pfam:Peptidase_S28 48 475 2.3e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000042390
SMART Domains Protein: ENSMUSP00000036996
Gene: ENSMUSG00000036646

low complexity region 3 11 N/A INTRINSIC
low complexity region 29 42 N/A INTRINSIC
transmembrane domain 49 71 N/A INTRINSIC
Pfam:Glyco_hydro_47 215 654 9.5e-167 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125248
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131665
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135473
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139108
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139971
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144218
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149953
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150305
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310035C23Rik T A 1: 105,719,464 L684M possibly damaging Het
Abca4 A G 3: 122,128,286 K1164E probably damaging Het
Arhgap42 G A 9: 8,998,248 probably benign Het
Arhgef12 T C 9: 42,999,077 D612G probably damaging Het
Cpne3 T C 4: 19,532,486 D309G probably benign Het
Daw1 T C 1: 83,197,213 probably benign Het
Daxx T A 17: 33,911,748 C246S probably damaging Het
Dync2h1 T A 9: 7,137,074 H1472L probably benign Het
Fastkd2 T C 1: 63,737,924 probably benign Het
Fcrls T G 3: 87,259,466 R73S probably damaging Het
Gatb A G 3: 85,618,916 D367G probably damaging Het
Gm20547 T A 17: 34,857,119 E654V probably damaging Het
Gm839 T A 6: 89,212,527 noncoding transcript Het
Gtf2ird2 A T 5: 134,217,614 M905L possibly damaging Het
Hoxb2 A T 11: 96,353,084 I174F probably damaging Het
Hrh3 A G 2: 180,100,815 V308A probably benign Het
Ints9 A G 14: 64,980,164 K47E probably benign Het
Irak3 A T 10: 120,182,661 Y61N probably damaging Het
Itpr1 A G 6: 108,381,315 E614G probably damaging Het
Lgals3 A T 14: 47,385,525 I214L probably benign Het
Msh4 G T 3: 153,872,325 T444K possibly damaging Het
Myh7b C A 2: 155,621,410 Q521K probably damaging Het
Naip5 T A 13: 100,223,028 I567F probably damaging Het
Nf1 A G 11: 79,434,933 probably benign Het
Nlrc3 C T 16: 3,954,023 probably benign Het
Nlrc5 A C 8: 94,506,573 E1353A possibly damaging Het
Nr1h3 T A 2: 91,190,566 I260F probably damaging Het
Pcnx G A 12: 81,964,120 R1211Q probably damaging Het
Pde10a A G 17: 8,949,461 K605E probably damaging Het
Pdzd2 T C 15: 12,382,622 E1215G possibly damaging Het
Pex12 A G 11: 83,297,927 S81P probably damaging Het
Pik3c2b C A 1: 133,066,980 Y227* probably null Het
Ppef2 C T 5: 92,235,900 W450* probably null Het
Prkg2 T G 5: 99,024,506 S117R probably benign Het
Prl3d2 A T 13: 27,127,283 E179D probably benign Het
Rxfp2 T C 5: 150,051,556 V210A probably benign Het
Scn10a T C 9: 119,609,560 T1748A possibly damaging Het
Sept10 T C 10: 59,192,178 N107S possibly damaging Het
Smu1 T A 4: 40,739,550 N420I probably damaging Het
Sos1 A G 17: 80,419,016 F835L probably benign Het
Spg11 T C 2: 122,058,398 D2164G probably damaging Het
Svbp A G 4: 119,195,930 E8G probably damaging Het
Tgm3 T A 2: 130,041,979 M519K probably damaging Het
Tspan12 A G 6: 21,799,877 probably null Het
Vps52 T C 17: 33,958,350 V122A probably damaging Het
Wipf1 T C 2: 73,434,083 Y458C probably damaging Het
Zfp369 T A 13: 65,294,451 D286E possibly damaging Het
Other mutations in Dpp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01637:Dpp7 APN 2 25354613 missense probably benign 0.01
IGL02897:Dpp7 APN 2 25353672 missense probably damaging 1.00
IGL03069:Dpp7 APN 2 25355723 critical splice acceptor site probably null
1mM(1):Dpp7 UTSW 2 25356140 missense probably benign 0.05
PIT4519001:Dpp7 UTSW 2 25352448 missense probably damaging 0.97
R0051:Dpp7 UTSW 2 25356095 missense possibly damaging 0.80
R0051:Dpp7 UTSW 2 25356095 missense possibly damaging 0.80
R0900:Dpp7 UTSW 2 25356299 missense probably damaging 0.99
R1889:Dpp7 UTSW 2 25353679 synonymous probably null
R1895:Dpp7 UTSW 2 25353679 synonymous probably null
R2055:Dpp7 UTSW 2 25354478 missense possibly damaging 0.84
R4697:Dpp7 UTSW 2 25354919 missense probably benign 0.00
R4832:Dpp7 UTSW 2 25352386 unclassified probably benign
R4887:Dpp7 UTSW 2 25352758 critical splice acceptor site probably null
R5114:Dpp7 UTSW 2 25352737 missense possibly damaging 0.51
R6976:Dpp7 UTSW 2 25354824 critical splice acceptor site probably null
X0058:Dpp7 UTSW 2 25354752 missense probably benign 0.05
Posted On2016-08-02