Incidental Mutation 'IGL00337:Sstr3'
ID 4074
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sstr3
Ensembl Gene ENSMUSG00000044933
Gene Name somatostatin receptor 3
Synonyms Smstr-3, Smstr3, sst3
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL00337
Quality Score
Status
Chromosome 15
Chromosomal Location 78421208-78428885 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 78424667 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 27 (T27S)
Ref Sequence ENSEMBL: ENSMUSP00000155582 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053239] [ENSMUST00000230400]
AlphaFold P30935
Predicted Effect probably benign
Transcript: ENSMUST00000053239
AA Change: T27S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000058040
Gene: ENSMUSG00000044933
AA Change: T27S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 53 291 1.9e-8 PFAM
Pfam:7TM_GPCR_Srsx 56 337 3.5e-15 PFAM
Pfam:7tm_1 62 322 6.3e-60 PFAM
Pfam:7TM_GPCR_Srv 121 337 9.5e-8 PFAM
coiled coil region 355 388 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000230400
AA Change: T27S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the somatostatin receptor protein family. Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This protein is functionally coupled to adenylyl cyclase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ap1ar A C 3: 127,614,400 (GRCm39) probably benign Het
Ap1ar A T 3: 127,614,401 (GRCm39) probably benign Het
Apip A T 2: 102,922,257 (GRCm39) T208S probably benign Het
Arhgap11a A G 2: 113,672,287 (GRCm39) V227A probably damaging Het
Atrn G T 2: 130,799,999 (GRCm39) V459F probably damaging Het
Cep295 T C 9: 15,237,368 (GRCm39) probably null Het
Cfhr1 A G 1: 139,484,253 (GRCm39) probably benign Het
D5Ertd615e A G 5: 45,320,769 (GRCm39) noncoding transcript Het
Dhx29 A G 13: 113,101,137 (GRCm39) I1227V probably benign Het
Fam98a T C 17: 75,858,742 (GRCm39) D16G probably damaging Het
Frk A G 10: 34,360,239 (GRCm39) D80G probably damaging Het
Gabbr2 A T 4: 46,787,600 (GRCm39) H354Q probably damaging Het
Ggps1 G A 13: 14,228,973 (GRCm39) S70L probably damaging Het
Gm4553 T C 7: 141,718,964 (GRCm39) S155G unknown Het
Hpx T C 7: 105,240,977 (GRCm39) Y432C probably damaging Het
Hyal2 T C 9: 107,449,371 (GRCm39) C376R probably damaging Het
Il10rb G A 16: 91,203,227 (GRCm39) A8T probably benign Het
Ing5 G T 1: 93,733,816 (GRCm39) M1I probably null Het
Kcnc4 C T 3: 107,355,189 (GRCm39) D420N probably benign Het
Kcnj8 T C 6: 142,515,961 (GRCm39) N49D probably damaging Het
Kif26b C A 1: 178,743,213 (GRCm39) A656D probably damaging Het
Klc4 T C 17: 46,946,361 (GRCm39) E488G probably damaging Het
Mtmr4 C T 11: 87,502,750 (GRCm39) H878Y probably benign Het
Ndufaf7 T C 17: 79,254,520 (GRCm39) probably benign Het
Nlrp14 T G 7: 106,781,308 (GRCm39) D168E possibly damaging Het
Ogdhl T C 14: 32,055,669 (GRCm39) F251S probably damaging Het
Or1p1 T C 11: 74,180,213 (GRCm39) V247A probably damaging Het
P2rx5 A T 11: 73,058,318 (GRCm39) probably null Het
Parp14 G A 16: 35,661,445 (GRCm39) T1501I probably benign Het
Prl3c1 C A 13: 27,384,746 (GRCm39) T85K probably damaging Het
Psg27 A G 7: 18,295,729 (GRCm39) Y239H probably damaging Het
Pzp T C 6: 128,493,872 (GRCm39) R300G probably benign Het
Sec16a A G 2: 26,329,499 (GRCm39) S839P probably benign Het
Sphkap T A 1: 83,317,329 (GRCm39) D56V probably damaging Het
Srrt C T 5: 137,294,240 (GRCm39) probably benign Het
Taf1d C A 9: 15,222,899 (GRCm39) S255Y probably damaging Het
Tbc1d15 C A 10: 115,045,546 (GRCm39) E473* probably null Het
Tmem247 T C 17: 87,224,963 (GRCm39) V24A probably benign Het
Txnrd2 T C 16: 18,296,519 (GRCm39) C494R probably damaging Het
Zfp180 A G 7: 23,784,894 (GRCm39) D5G probably damaging Het
Other mutations in Sstr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0442:Sstr3 UTSW 15 78,424,597 (GRCm39) missense probably damaging 0.99
R1714:Sstr3 UTSW 15 78,424,473 (GRCm39) missense probably damaging 1.00
R1865:Sstr3 UTSW 15 78,424,168 (GRCm39) missense probably damaging 1.00
R2008:Sstr3 UTSW 15 78,424,711 (GRCm39) missense probably benign 0.14
R2351:Sstr3 UTSW 15 78,424,121 (GRCm39) missense probably benign 0.01
R3023:Sstr3 UTSW 15 78,424,187 (GRCm39) missense probably damaging 0.99
R3024:Sstr3 UTSW 15 78,424,187 (GRCm39) missense probably damaging 0.99
R3770:Sstr3 UTSW 15 78,424,577 (GRCm39) missense probably damaging 1.00
R4399:Sstr3 UTSW 15 78,424,324 (GRCm39) missense probably damaging 1.00
R4724:Sstr3 UTSW 15 78,423,897 (GRCm39) nonsense probably null
R6181:Sstr3 UTSW 15 78,423,661 (GRCm39) missense probably benign
R6247:Sstr3 UTSW 15 78,423,788 (GRCm39) missense probably damaging 0.99
R7450:Sstr3 UTSW 15 78,424,043 (GRCm39) missense probably damaging 1.00
R7578:Sstr3 UTSW 15 78,424,717 (GRCm39) missense probably benign
R7793:Sstr3 UTSW 15 78,424,588 (GRCm39) missense probably damaging 1.00
R8336:Sstr3 UTSW 15 78,424,693 (GRCm39) missense probably damaging 1.00
R9263:Sstr3 UTSW 15 78,423,792 (GRCm39) missense probably damaging 1.00
R9264:Sstr3 UTSW 15 78,423,792 (GRCm39) missense probably damaging 1.00
R9265:Sstr3 UTSW 15 78,423,792 (GRCm39) missense probably damaging 1.00
X0026:Sstr3 UTSW 15 78,423,574 (GRCm39) missense possibly damaging 0.57
Z1177:Sstr3 UTSW 15 78,423,503 (GRCm39) nonsense probably null
Posted On 2012-04-20