Incidental Mutation 'IGL03008:Wdr11'
ID 407683
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr11
Ensembl Gene ENSMUSG00000042055
Gene Name WD repeat domain 11
Synonyms Wdr11, Brwd2, 2900055P10Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.245) question?
Stock # IGL03008
Quality Score
Status
Chromosome 7
Chromosomal Location 129193587-129237462 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 129208715 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000084519]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000084519
SMART Domains Protein: ENSMUSP00000081567
Gene: ENSMUSG00000042055

DomainStartEndE-ValueType
WD40 50 99 2e-1 SMART
WD40 102 145 2.84e2 SMART
low complexity region 189 200 N/A INTRINSIC
low complexity region 213 227 N/A INTRINSIC
low complexity region 454 465 N/A INTRINSIC
WD40 552 595 4.42e1 SMART
WD40 696 735 1.66e0 SMART
WD40 737 777 1.43e1 SMART
WD40 780 821 1.38e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136734
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143422
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143849
Predicted Effect probably benign
Transcript: ENSMUST00000148752
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149541
Predicted Effect probably benign
Transcript: ENSMUST00000206442
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aga T C 8: 53,964,861 (GRCm39) S8P probably benign Het
Ankrd34c C T 9: 89,612,337 (GRCm39) M1I probably null Het
Ankrd44 T C 1: 54,805,968 (GRCm39) H146R probably damaging Het
Bst1 A G 5: 43,983,604 (GRCm39) probably null Het
Btbd8 T G 5: 107,639,464 (GRCm39) probably null Het
Cdh12 A T 15: 21,480,416 (GRCm39) I211F probably damaging Het
Cenpj G T 14: 56,764,406 (GRCm39) D1335E probably benign Het
Clpx G A 9: 65,230,057 (GRCm39) V502I possibly damaging Het
Cntnap4 T C 8: 113,500,222 (GRCm39) S505P probably benign Het
Cog2 T C 8: 125,262,131 (GRCm39) probably benign Het
Cped1 A G 6: 22,233,601 (GRCm39) Q819R probably benign Het
Cspg4 A G 9: 56,805,759 (GRCm39) E2190G possibly damaging Het
Ctsa G A 2: 164,679,368 (GRCm39) R359Q probably damaging Het
Cul9 A G 17: 46,813,623 (GRCm39) probably benign Het
Dab1 G T 4: 104,584,777 (GRCm39) V306F probably damaging Het
Dysf A G 6: 84,050,876 (GRCm39) I438V probably benign Het
Eif4g3 G T 4: 137,847,699 (GRCm39) G380W probably damaging Het
Exd1 T A 2: 119,350,862 (GRCm39) K466N probably benign Het
Eya3 A C 4: 132,434,294 (GRCm39) D325A probably damaging Het
Fmn1 A G 2: 113,195,445 (GRCm39) T382A unknown Het
Fry T A 5: 150,269,021 (GRCm39) D106E possibly damaging Het
Gm21957 T A 7: 124,818,733 (GRCm39) noncoding transcript Het
Gm44511 A G 6: 128,761,059 (GRCm39) probably benign Het
Itga4 A G 2: 79,155,982 (GRCm39) I983V probably benign Het
Lrpprc A T 17: 85,058,675 (GRCm39) D5E probably benign Het
Lrrc37 T C 11: 103,511,293 (GRCm39) E225G unknown Het
Ltbp4 G T 7: 27,023,789 (GRCm39) N747K probably damaging Het
Minar1 A G 9: 89,478,731 (GRCm39) Y772H probably damaging Het
Mlh3 T C 12: 85,287,625 (GRCm39) Q1308R probably benign Het
Mtfr2 T A 10: 20,229,185 (GRCm39) C63S possibly damaging Het
Myh11 T A 16: 14,022,617 (GRCm39) M1661L probably benign Het
Myo1c T C 11: 75,549,240 (GRCm39) M137T probably benign Het
Myocd A C 11: 65,078,392 (GRCm39) L340V probably damaging Het
Napsa A T 7: 44,235,220 (GRCm39) Q335L possibly damaging Het
Nlrp4b C A 7: 10,448,516 (GRCm39) Q240K probably benign Het
Npepps A C 11: 97,128,984 (GRCm39) F400C probably damaging Het
Nxpe4 A T 9: 48,304,738 (GRCm39) E275V probably benign Het
Ofd1 T C X: 165,192,530 (GRCm39) D501G probably benign Het
Or13a19 T C 7: 139,903,445 (GRCm39) Y278H probably damaging Het
Or4f6 A G 2: 111,838,868 (GRCm39) I221T possibly damaging Het
Or5p79 T G 7: 108,221,490 (GRCm39) L157R probably damaging Het
Or8k41 A T 2: 86,313,678 (GRCm39) M136K probably damaging Het
P2ry1 A T 3: 60,910,947 (GRCm39) T29S probably benign Het
Papss1 T C 3: 131,290,860 (GRCm39) V201A possibly damaging Het
Paxip1 A G 5: 27,957,764 (GRCm39) V864A probably benign Het
Pcdhgc5 T A 18: 37,954,887 (GRCm39) H720Q probably benign Het
Pdxdc1 T C 16: 13,694,023 (GRCm39) N133S possibly damaging Het
Prkar1a T C 11: 109,544,690 (GRCm39) I27T probably damaging Het
Rnf10 G T 5: 115,389,355 (GRCm39) H271N possibly damaging Het
Scn9a A G 2: 66,392,855 (GRCm39) S246P probably damaging Het
Sertad2 G T 11: 20,597,798 (GRCm39) probably benign Het
Slc22a27 A G 19: 7,887,067 (GRCm39) I274T possibly damaging Het
Slc22a5 A T 11: 53,782,058 (GRCm39) V103E probably damaging Het
Slc5a9 A T 4: 111,748,138 (GRCm39) F225I probably benign Het
Slc6a3 G A 13: 73,706,404 (GRCm39) probably null Het
Smcr8 A G 11: 60,669,287 (GRCm39) E145G probably damaging Het
Spen A T 4: 141,203,448 (GRCm39) D1726E possibly damaging Het
Sphkap A T 1: 83,254,552 (GRCm39) S779T probably damaging Het
Stag1 A T 9: 100,658,844 (GRCm39) N144Y probably damaging Het
Strada T C 11: 106,061,783 (GRCm39) H156R probably damaging Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Tas2r138 A C 6: 40,590,116 (GRCm39) D43E probably damaging Het
Tdpoz3 A T 3: 93,733,642 (GRCm39) K106* probably null Het
Trbv13-1 A G 6: 41,093,229 (GRCm39) D54G probably damaging Het
Ttc39b A G 4: 83,165,932 (GRCm39) V218A probably benign Het
Ttn G A 2: 76,611,203 (GRCm39) T15697I probably damaging Het
Ugt2b38 G A 5: 87,560,282 (GRCm39) T344I probably benign Het
Vmn2r94 T C 17: 18,477,908 (GRCm39) M168V probably benign Het
Wipf2 T C 11: 98,783,554 (GRCm39) probably benign Het
Zranb2 T A 3: 157,252,302 (GRCm39) probably null Het
Other mutations in Wdr11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00834:Wdr11 APN 7 129,194,817 (GRCm39) splice site probably null
IGL01121:Wdr11 APN 7 129,229,746 (GRCm39) missense probably benign 0.02
IGL01385:Wdr11 APN 7 129,209,637 (GRCm39) missense probably benign
IGL01923:Wdr11 APN 7 129,234,046 (GRCm39) critical splice acceptor site probably null
IGL02274:Wdr11 APN 7 129,232,896 (GRCm39) critical splice acceptor site probably null
IGL02894:Wdr11 APN 7 129,232,890 (GRCm39) splice site probably benign
IGL02927:Wdr11 APN 7 129,208,822 (GRCm39) critical splice donor site probably null
IGL03026:Wdr11 APN 7 129,226,060 (GRCm39) missense probably damaging 1.00
IGL03354:Wdr11 APN 7 129,227,026 (GRCm39) missense probably benign 0.01
IGL03379:Wdr11 APN 7 129,200,847 (GRCm39) missense probably damaging 1.00
beeline UTSW 7 129,207,437 (GRCm39) nonsense probably null
bekummernis UTSW 7 129,226,451 (GRCm39) missense probably damaging 0.97
hort UTSW 7 129,232,523 (GRCm39) critical splice donor site probably null
Knees UTSW 7 129,236,560 (GRCm39) missense probably benign 0.02
Propeller UTSW 7 129,208,399 (GRCm39) missense possibly damaging 0.91
Zuversicht UTSW 7 129,208,264 (GRCm39) missense probably benign 0.13
R0003:Wdr11 UTSW 7 129,200,785 (GRCm39) missense probably damaging 1.00
R0928:Wdr11 UTSW 7 129,208,377 (GRCm39) missense probably damaging 1.00
R1170:Wdr11 UTSW 7 129,208,831 (GRCm39) unclassified probably benign
R1645:Wdr11 UTSW 7 129,215,613 (GRCm39) missense probably benign 0.29
R1908:Wdr11 UTSW 7 129,206,954 (GRCm39) missense possibly damaging 0.60
R1938:Wdr11 UTSW 7 129,208,331 (GRCm39) missense probably benign 0.08
R2122:Wdr11 UTSW 7 129,233,490 (GRCm39) missense probably damaging 1.00
R2148:Wdr11 UTSW 7 129,230,807 (GRCm39) splice site probably null
R2240:Wdr11 UTSW 7 129,207,418 (GRCm39) critical splice acceptor site probably null
R2362:Wdr11 UTSW 7 129,236,560 (GRCm39) missense probably benign 0.05
R3774:Wdr11 UTSW 7 129,233,417 (GRCm39) splice site probably null
R4297:Wdr11 UTSW 7 129,226,910 (GRCm39) missense probably benign 0.18
R4546:Wdr11 UTSW 7 129,230,729 (GRCm39) missense probably damaging 1.00
R4787:Wdr11 UTSW 7 129,210,658 (GRCm39) splice site probably benign
R4789:Wdr11 UTSW 7 129,220,394 (GRCm39) nonsense probably null
R4807:Wdr11 UTSW 7 129,229,746 (GRCm39) missense probably benign 0.02
R4855:Wdr11 UTSW 7 129,202,158 (GRCm39) splice site probably null
R4898:Wdr11 UTSW 7 129,235,445 (GRCm39) missense probably benign
R5022:Wdr11 UTSW 7 129,226,435 (GRCm39) missense probably benign 0.10
R5326:Wdr11 UTSW 7 129,226,973 (GRCm39) missense probably damaging 1.00
R5398:Wdr11 UTSW 7 129,232,956 (GRCm39) missense probably damaging 1.00
R6120:Wdr11 UTSW 7 129,226,515 (GRCm39) missense probably damaging 0.99
R6136:Wdr11 UTSW 7 129,220,427 (GRCm39) missense possibly damaging 0.86
R6280:Wdr11 UTSW 7 129,200,830 (GRCm39) nonsense probably null
R6352:Wdr11 UTSW 7 129,208,399 (GRCm39) missense possibly damaging 0.91
R6432:Wdr11 UTSW 7 129,208,242 (GRCm39) missense possibly damaging 0.83
R6766:Wdr11 UTSW 7 129,226,036 (GRCm39) missense probably benign 0.02
R6911:Wdr11 UTSW 7 129,208,819 (GRCm39) missense probably benign 0.28
R7135:Wdr11 UTSW 7 129,229,830 (GRCm39) missense possibly damaging 0.76
R7151:Wdr11 UTSW 7 129,208,376 (GRCm39) missense probably damaging 1.00
R7463:Wdr11 UTSW 7 129,208,810 (GRCm39) missense probably damaging 0.99
R7503:Wdr11 UTSW 7 129,204,834 (GRCm39) missense probably benign
R8097:Wdr11 UTSW 7 129,209,611 (GRCm39) missense probably damaging 1.00
R8254:Wdr11 UTSW 7 129,236,560 (GRCm39) missense probably benign 0.02
R8354:Wdr11 UTSW 7 129,204,723 (GRCm39) missense probably damaging 0.99
R8377:Wdr11 UTSW 7 129,208,412 (GRCm39) missense possibly damaging 0.56
R8416:Wdr11 UTSW 7 129,232,403 (GRCm39) missense possibly damaging 0.62
R8708:Wdr11 UTSW 7 129,200,780 (GRCm39) missense probably benign 0.07
R8896:Wdr11 UTSW 7 129,207,437 (GRCm39) nonsense probably null
R9092:Wdr11 UTSW 7 129,226,451 (GRCm39) missense probably damaging 0.97
R9136:Wdr11 UTSW 7 129,204,816 (GRCm39) missense
R9315:Wdr11 UTSW 7 129,208,264 (GRCm39) missense probably benign 0.13
R9343:Wdr11 UTSW 7 129,232,523 (GRCm39) critical splice donor site probably null
R9663:Wdr11 UTSW 7 129,210,647 (GRCm39) missense probably damaging 1.00
R9771:Wdr11 UTSW 7 129,206,851 (GRCm39) missense probably damaging 1.00
Z1177:Wdr11 UTSW 7 129,209,602 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02