Incidental Mutation 'IGL03012:Vmn1r78'
ID407815
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r78
Ensembl Gene ENSMUSG00000061602
Gene Namevomeronasal 1 receptor 78
SynonymsV1rg7
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL03012
Quality Score
Status
Chromosome7
Chromosomal Location12150257-12159959 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 12153364 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 301 (S301T)
Ref Sequence ENSEMBL: ENSMUSP00000154797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]
Predicted Effect probably benign
Transcript: ENSMUST00000078039
AA Change: S301T

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: S301T

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 5.7e-8 PFAM
Pfam:V1R 12 301 1.5e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209489
Predicted Effect probably benign
Transcript: ENSMUST00000228244
AA Change: S301T

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000228664
AA Change: S301T

PolyPhen 2 Score 0.317 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaa1b A C 9: 119,156,946 S17A probably benign Het
Acp1 T G 12: 30,895,949 N135T probably benign Het
Adamts2 A G 11: 50,776,269 probably benign Het
Arfgef2 C T 2: 166,868,888 probably benign Het
Atp10b T A 11: 43,194,655 I287N probably damaging Het
Camta1 T A 4: 151,453,299 K141N probably damaging Het
Carmil1 T C 13: 24,036,372 D719G probably benign Het
Cntnap5c T A 17: 58,359,234 H1086Q probably benign Het
Dsg3 A G 18: 20,537,243 probably null Het
Emilin3 G A 2: 160,908,729 Q320* probably null Het
G6pd2 A G 5: 61,809,473 Y197C probably damaging Het
Il13ra1 G T X: 36,130,594 probably benign Het
Ivl G A 3: 92,572,426 P111S probably benign Het
Kmt2a T C 9: 44,810,966 probably benign Het
Lztr1 T C 16: 17,521,484 S57P possibly damaging Het
Mtss1 T G 15: 59,058,400 D32A probably damaging Het
Mylk G A 16: 34,952,781 D1250N probably benign Het
Ncln A G 10: 81,489,965 F349L probably benign Het
Pgap1 A G 1: 54,533,413 probably benign Het
Rarres2 T C 6: 48,570,305 D107G probably benign Het
Ric3 T C 7: 109,038,718 D276G probably benign Het
Trim54 A G 5: 31,137,145 D339G probably benign Het
Trip11 G A 12: 101,883,936 H1005Y probably damaging Het
Tulp4 G T 17: 6,213,379 probably benign Het
Unc93a C T 17: 13,109,608 E453K probably benign Het
Vmn1r181 A T 7: 23,984,602 D164V probably damaging Het
Vmn1r85 T C 7: 13,084,765 N151D probably benign Het
Wnk2 T C 13: 49,044,389 K2008E probably damaging Het
Wrap73 A G 4: 154,145,234 probably benign Het
Zfp408 G A 2: 91,647,808 A41V probably benign Het
Zfp472 A G 17: 32,977,571 S207G probably benign Het
Other mutations in Vmn1r78
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Vmn1r78 APN 7 12153238 missense probably benign 0.10
IGL02019:Vmn1r78 APN 7 12152707 missense probably damaging 0.99
IGL02143:Vmn1r78 APN 7 12152480 missense probably benign
IGL02154:Vmn1r78 APN 7 12152545 missense probably benign 0.22
IGL02290:Vmn1r78 APN 7 12153155 missense probably damaging 1.00
IGL03256:Vmn1r78 APN 7 12152798 missense probably damaging 1.00
IGL03373:Vmn1r78 APN 7 12153343 missense possibly damaging 0.86
IGL03384:Vmn1r78 APN 7 12153209 missense possibly damaging 0.94
R0016:Vmn1r78 UTSW 7 12153352 missense probably benign 0.02
R1445:Vmn1r78 UTSW 7 12152581 missense possibly damaging 0.64
R1748:Vmn1r78 UTSW 7 12153323 missense probably damaging 1.00
R2017:Vmn1r78 UTSW 7 12153343 missense possibly damaging 0.86
R2032:Vmn1r78 UTSW 7 12153283 missense probably benign 0.00
R2198:Vmn1r78 UTSW 7 12152560 missense probably benign 0.06
R4330:Vmn1r78 UTSW 7 12152459 unclassified probably null
R4564:Vmn1r78 UTSW 7 12152558 missense probably damaging 1.00
R4769:Vmn1r78 UTSW 7 12152798 missense probably damaging 1.00
R4801:Vmn1r78 UTSW 7 12152964 nonsense probably null
R4802:Vmn1r78 UTSW 7 12152964 nonsense probably null
R4860:Vmn1r78 UTSW 7 12152756 missense probably damaging 1.00
R4860:Vmn1r78 UTSW 7 12152756 missense probably damaging 1.00
R5648:Vmn1r78 UTSW 7 12152766 missense possibly damaging 0.92
R6561:Vmn1r78 UTSW 7 12152899 missense probably damaging 1.00
R6869:Vmn1r78 UTSW 7 12152749 missense probably benign 0.01
R6945:Vmn1r78 UTSW 7 12152905 missense probably benign 0.01
Z1088:Vmn1r78 UTSW 7 12152714 missense probably damaging 1.00
Posted On2016-08-02