Incidental Mutation 'R0025:Dock3'
| ID |
40793 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock3
|
| Ensembl Gene |
ENSMUSG00000039716 |
| Gene Name |
dedicator of cyto-kinesis 3 |
| Synonyms |
Moca, PBP |
| MMRRC Submission |
038320-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.549)
|
| Stock # |
R0025 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
106770024-107109108 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 106790467 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Lysine
at position 1419
(Q1419K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000047652
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044532]
[ENSMUST00000171095]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044532
AA Change: Q1419K
PolyPhen 2
Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000047652
Gene: ENSMUSG00000039716
AA Change: Q1419K
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
9 |
66 |
3.85e-9 |
SMART |
|
Pfam:DOCK_N
|
69 |
412 |
1.4e-120 |
PFAM |
|
Pfam:DOCK-C2
|
417 |
608 |
7.7e-56 |
PFAM |
|
low complexity region
|
854 |
867 |
N/A |
INTRINSIC |
|
low complexity region
|
892 |
916 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1121 |
1628 |
9e-133 |
PFAM |
|
low complexity region
|
1679 |
1690 |
N/A |
INTRINSIC |
|
low complexity region
|
1693 |
1704 |
N/A |
INTRINSIC |
|
low complexity region
|
1730 |
1754 |
N/A |
INTRINSIC |
|
low complexity region
|
1880 |
1902 |
N/A |
INTRINSIC |
|
low complexity region
|
1963 |
1977 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000165562
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000166759
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168759
|
| SMART Domains |
Protein: ENSMUSP00000131410
Gene: ENSMUSG00000039716
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DHR-2
|
1 |
241 |
4e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171095
|
| SMART Domains |
Protein: ENSMUSP00000127059
Gene: ENSMUSG00000039716
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Ded_cyto
|
1 |
172 |
8.9e-52 |
PFAM |
|
low complexity region
|
223 |
234 |
N/A |
INTRINSIC |
|
low complexity region
|
237 |
248 |
N/A |
INTRINSIC |
|
low complexity region
|
260 |
275 |
N/A |
INTRINSIC |
|
low complexity region
|
402 |
424 |
N/A |
INTRINSIC |
|
low complexity region
|
485 |
499 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.5029 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.7%
- 20x: 90.3%
|
| Validation Efficiency |
98% (115/117) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit abnormal behaviors and muscular weakness associated with axonal dystrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm1 |
A |
T |
7: 119,257,538 (GRCm39) |
T435S |
probably damaging |
Het |
| Agtpbp1 |
G |
A |
13: 59,648,014 (GRCm39) |
T602I |
probably benign |
Het |
| Ahnak2 |
T |
A |
12: 112,749,154 (GRCm39) |
D231V |
probably damaging |
Het |
| Ampd3 |
G |
A |
7: 110,392,876 (GRCm39) |
D215N |
probably benign |
Het |
| Ankrd17 |
T |
C |
5: 90,398,264 (GRCm39) |
D1762G |
probably damaging |
Het |
| Asb8 |
C |
T |
15: 98,040,552 (GRCm39) |
V37I |
possibly damaging |
Het |
| Bicra |
T |
C |
7: 15,721,436 (GRCm39) |
T694A |
possibly damaging |
Het |
| Btnl6 |
A |
T |
17: 34,733,273 (GRCm39) |
M234K |
probably benign |
Het |
| Ccnb1 |
A |
T |
13: 100,916,289 (GRCm39) |
V336D |
probably damaging |
Het |
| Cdca8 |
A |
T |
4: 124,815,047 (GRCm39) |
L190Q |
possibly damaging |
Het |
| Cep290 |
A |
T |
10: 100,373,693 (GRCm39) |
L1324F |
probably damaging |
Het |
| Ces1f |
T |
C |
8: 93,998,513 (GRCm39) |
E161G |
probably benign |
Het |
| Ces2g |
A |
G |
8: 105,692,628 (GRCm39) |
|
probably benign |
Het |
| Cfap74 |
C |
T |
4: 155,510,572 (GRCm39) |
R386C |
probably benign |
Het |
| Clec3b |
A |
G |
9: 122,986,090 (GRCm39) |
T163A |
probably benign |
Het |
| Cntnap4 |
T |
G |
8: 113,529,796 (GRCm39) |
L668R |
probably damaging |
Het |
| Col27a1 |
A |
G |
4: 63,194,214 (GRCm39) |
D857G |
probably damaging |
Het |
| Csf1 |
A |
G |
3: 107,655,960 (GRCm39) |
V245A |
probably benign |
Het |
| Ctss |
A |
G |
3: 95,457,448 (GRCm39) |
Y302C |
probably damaging |
Het |
| Cyb5d1 |
A |
G |
11: 69,285,792 (GRCm39) |
|
probably null |
Het |
| Cyp1a2 |
A |
G |
9: 57,589,344 (GRCm39) |
S157P |
probably damaging |
Het |
| Cyp2b9 |
A |
T |
7: 25,900,238 (GRCm39) |
T349S |
probably benign |
Het |
| Dennd6b |
T |
C |
15: 89,070,386 (GRCm39) |
I428V |
probably benign |
Het |
| Denr |
A |
G |
5: 124,065,298 (GRCm39) |
|
probably benign |
Het |
| Dnah9 |
G |
A |
11: 65,860,781 (GRCm39) |
|
probably benign |
Het |
| Dph3b-ps |
A |
T |
13: 106,683,375 (GRCm39) |
|
noncoding transcript |
Het |
| Emc7 |
G |
T |
2: 112,289,830 (GRCm39) |
D87Y |
probably damaging |
Het |
| Enah |
T |
C |
1: 181,740,938 (GRCm39) |
E462G |
possibly damaging |
Het |
| Eno1b |
T |
C |
18: 48,180,806 (GRCm39) |
I328T |
probably benign |
Het |
| Enpp6 |
A |
G |
8: 47,519,035 (GRCm39) |
K268E |
probably damaging |
Het |
| Eps15l1 |
T |
G |
8: 73,135,341 (GRCm39) |
|
probably benign |
Het |
| Fam151a |
T |
C |
4: 106,605,371 (GRCm39) |
Y578H |
probably benign |
Het |
| Fmn2 |
T |
C |
1: 174,618,880 (GRCm39) |
V1512A |
probably damaging |
Het |
| Focad |
C |
A |
4: 88,327,196 (GRCm39) |
N168K |
probably benign |
Het |
| Fyco1 |
A |
G |
9: 123,658,074 (GRCm39) |
C701R |
probably damaging |
Het |
| Gabbr1 |
G |
T |
17: 37,378,102 (GRCm39) |
|
probably benign |
Het |
| Golga7b |
A |
T |
19: 42,255,278 (GRCm39) |
E76V |
probably damaging |
Het |
| Gucy2d |
A |
G |
7: 98,116,959 (GRCm39) |
D924G |
probably benign |
Het |
| H2-M9 |
A |
G |
17: 36,952,647 (GRCm39) |
F133S |
probably damaging |
Het |
| Hc |
A |
G |
2: 34,876,304 (GRCm39) |
Y1581H |
probably damaging |
Het |
| Herc3 |
C |
T |
6: 58,851,293 (GRCm39) |
P514L |
probably damaging |
Het |
| Hormad1 |
T |
C |
3: 95,492,436 (GRCm39) |
|
probably benign |
Het |
| Iigp1 |
T |
A |
18: 60,523,859 (GRCm39) |
S326T |
possibly damaging |
Het |
| Itga2 |
G |
A |
13: 115,007,032 (GRCm39) |
S432L |
possibly damaging |
Het |
| Kcnk7 |
T |
G |
19: 5,757,042 (GRCm39) |
*344G |
probably null |
Het |
| Kif13a |
A |
G |
13: 46,939,987 (GRCm39) |
|
probably null |
Het |
| Kif1a |
A |
C |
1: 92,970,080 (GRCm39) |
I1027S |
probably damaging |
Het |
| Kif2c |
G |
T |
4: 117,022,714 (GRCm39) |
H416Q |
probably damaging |
Het |
| Liat1 |
AGAGGAGGAGGAGGAGG |
AGAGGAGGAGGAGG |
11: 75,890,941 (GRCm39) |
|
probably benign |
Het |
| Map3k1 |
A |
G |
13: 111,892,663 (GRCm39) |
V864A |
probably benign |
Het |
| Mark2 |
T |
C |
19: 7,263,287 (GRCm39) |
D160G |
probably damaging |
Het |
| Mbd4 |
A |
G |
6: 115,821,529 (GRCm39) |
|
probably null |
Het |
| Micu1 |
A |
G |
10: 59,624,699 (GRCm39) |
|
probably null |
Het |
| Mink1 |
T |
C |
11: 70,503,868 (GRCm39) |
W1263R |
probably damaging |
Het |
| Mov10 |
A |
C |
3: 104,711,919 (GRCm39) |
L224R |
probably damaging |
Het |
| Ndel1 |
T |
C |
11: 68,726,999 (GRCm39) |
E226G |
probably damaging |
Het |
| Neb |
A |
T |
2: 52,112,786 (GRCm39) |
V4336E |
probably damaging |
Het |
| Nln |
T |
A |
13: 104,173,399 (GRCm39) |
K602N |
probably damaging |
Het |
| Nlrp14 |
A |
T |
7: 106,780,465 (GRCm39) |
|
probably benign |
Het |
| Nmd3 |
A |
T |
3: 69,655,654 (GRCm39) |
D445V |
probably damaging |
Het |
| Nop14 |
T |
C |
5: 34,801,297 (GRCm39) |
I625V |
probably benign |
Het |
| Notch1 |
T |
C |
2: 26,360,943 (GRCm39) |
Q1134R |
probably damaging |
Het |
| Nr4a2 |
T |
C |
2: 56,998,627 (GRCm39) |
I392M |
probably benign |
Het |
| Or13n4 |
A |
G |
7: 106,422,963 (GRCm39) |
F257L |
possibly damaging |
Het |
| Or4f6 |
T |
A |
2: 111,839,365 (GRCm39) |
L55F |
probably damaging |
Het |
| Or8b57 |
A |
G |
9: 40,003,549 (GRCm39) |
S234P |
probably damaging |
Het |
| Osbp |
T |
C |
19: 11,961,322 (GRCm39) |
Y454H |
probably damaging |
Het |
| Pak4 |
G |
A |
7: 28,263,708 (GRCm39) |
R343C |
probably damaging |
Het |
| Pak5 |
T |
C |
2: 135,942,704 (GRCm39) |
K479E |
possibly damaging |
Het |
| Pard3 |
C |
A |
8: 127,888,058 (GRCm39) |
D73E |
probably damaging |
Het |
| Pcdh10 |
T |
C |
3: 45,334,934 (GRCm39) |
V416A |
possibly damaging |
Het |
| Plek |
A |
C |
11: 16,935,594 (GRCm39) |
W261G |
probably damaging |
Het |
| Pmp22 |
A |
T |
11: 63,049,076 (GRCm39) |
|
probably null |
Het |
| Prph2 |
A |
C |
17: 47,230,697 (GRCm39) |
K197Q |
probably benign |
Het |
| Prss45 |
T |
A |
9: 110,669,962 (GRCm39) |
L257Q |
probably damaging |
Het |
| Psmb6 |
C |
A |
11: 70,417,171 (GRCm39) |
H73Q |
probably benign |
Het |
| Rin2 |
T |
C |
2: 145,720,752 (GRCm39) |
|
probably benign |
Het |
| Rps6kb1 |
A |
T |
11: 86,402,413 (GRCm39) |
|
probably null |
Het |
| Scn10a |
C |
A |
9: 119,499,550 (GRCm39) |
D248Y |
probably damaging |
Het |
| Scn4a |
C |
T |
11: 106,215,386 (GRCm39) |
V1197I |
probably benign |
Het |
| Siglecf |
A |
T |
7: 43,001,349 (GRCm39) |
I106F |
probably benign |
Het |
| Sik1 |
A |
G |
17: 32,066,249 (GRCm39) |
|
probably benign |
Het |
| Slc22a21 |
T |
G |
11: 53,870,514 (GRCm39) |
N57T |
probably damaging |
Het |
| Slc36a2 |
A |
G |
11: 55,053,621 (GRCm39) |
L339P |
probably damaging |
Het |
| Slc4a9 |
G |
T |
18: 36,664,719 (GRCm39) |
|
probably benign |
Het |
| Smg1 |
G |
A |
7: 117,811,666 (GRCm39) |
T104I |
possibly damaging |
Het |
| Stc2 |
A |
T |
11: 31,315,559 (GRCm39) |
|
probably null |
Het |
| Stx18 |
T |
A |
5: 38,249,908 (GRCm39) |
Y74N |
probably damaging |
Het |
| Stxbp5 |
A |
T |
10: 9,638,492 (GRCm39) |
H1102Q |
probably damaging |
Het |
| Tnfaip8l2 |
G |
A |
3: 95,047,339 (GRCm39) |
L175F |
probably damaging |
Het |
| Tom1l2 |
T |
C |
11: 60,120,960 (GRCm39) |
K450E |
probably damaging |
Het |
| Tpo |
T |
C |
12: 30,150,389 (GRCm39) |
Q497R |
probably benign |
Het |
| Tprg1l |
G |
T |
4: 154,244,802 (GRCm39) |
|
probably benign |
Het |
| Triml2 |
A |
G |
8: 43,638,469 (GRCm39) |
M146V |
probably benign |
Het |
| Tsc2 |
A |
G |
17: 24,849,978 (GRCm39) |
|
probably benign |
Het |
| Tut7 |
A |
T |
13: 59,953,142 (GRCm39) |
D99E |
probably benign |
Het |
| Vit |
G |
A |
17: 78,907,264 (GRCm39) |
G229R |
probably benign |
Het |
| Vmn2r19 |
C |
T |
6: 123,308,506 (GRCm39) |
L528F |
probably benign |
Het |
| Vwf |
T |
A |
6: 125,659,775 (GRCm39) |
I2658N |
probably benign |
Het |
| Wdfy3 |
T |
C |
5: 101,992,912 (GRCm39) |
D3341G |
probably damaging |
Het |
| Wdr36 |
T |
A |
18: 32,992,360 (GRCm39) |
D632E |
probably damaging |
Het |
| Wdr47 |
G |
T |
3: 108,545,307 (GRCm39) |
A733S |
probably damaging |
Het |
| Zfp458 |
T |
A |
13: 67,405,962 (GRCm39) |
H156L |
probably damaging |
Het |
| Zfp654 |
A |
G |
16: 64,605,181 (GRCm39) |
V466A |
probably benign |
Het |
| Zfp804b |
T |
C |
5: 6,821,665 (GRCm39) |
E466G |
probably damaging |
Het |
| Zfp941 |
T |
C |
7: 140,393,185 (GRCm39) |
D58G |
probably benign |
Het |
|
| Other mutations in Dock3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00940:Dock3
|
APN |
9 |
106,788,576 (GRCm39) |
splice site |
probably benign |
|
|
IGL01067:Dock3
|
APN |
9 |
106,959,572 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01160:Dock3
|
APN |
9 |
106,783,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01290:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01291:Dock3
|
APN |
9 |
106,835,599 (GRCm39) |
splice site |
probably benign |
|
|
IGL01391:Dock3
|
APN |
9 |
106,784,433 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01399:Dock3
|
APN |
9 |
106,870,670 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01660:Dock3
|
APN |
9 |
106,909,563 (GRCm39) |
splice site |
probably benign |
|
|
IGL01752:Dock3
|
APN |
9 |
106,902,512 (GRCm39) |
splice site |
probably benign |
|
|
IGL01820:Dock3
|
APN |
9 |
106,773,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01908:Dock3
|
APN |
9 |
106,783,861 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02191:Dock3
|
APN |
9 |
106,815,340 (GRCm39) |
missense |
probably benign |
|
|
IGL02227:Dock3
|
APN |
9 |
106,939,254 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02309:Dock3
|
APN |
9 |
106,790,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Dock3
|
APN |
9 |
106,790,298 (GRCm39) |
splice site |
probably benign |
|
|
IGL02469:Dock3
|
APN |
9 |
106,863,215 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02545:Dock3
|
APN |
9 |
106,939,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Dock3
|
APN |
9 |
106,807,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Dock3
|
APN |
9 |
106,900,944 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03027:Dock3
|
APN |
9 |
106,870,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03068:Dock3
|
APN |
9 |
106,841,958 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03128:Dock3
|
APN |
9 |
106,909,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03161:Dock3
|
APN |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03263:Dock3
|
APN |
9 |
106,807,330 (GRCm39) |
splice site |
probably benign |
|
|
IGL03279:Dock3
|
APN |
9 |
106,788,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL03366:Dock3
|
APN |
9 |
106,882,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
Implosion
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
Squeeze
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Tight
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
ANU05:Dock3
|
UTSW |
9 |
106,772,862 (GRCm39) |
missense |
probably benign |
|
|
R0025:Dock3
|
UTSW |
9 |
106,790,467 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0030:Dock3
|
UTSW |
9 |
106,789,512 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0076:Dock3
|
UTSW |
9 |
106,788,685 (GRCm39) |
splice site |
probably benign |
|
|
R0206:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0208:Dock3
|
UTSW |
9 |
106,874,195 (GRCm39) |
nonsense |
probably null |
|
|
R0384:Dock3
|
UTSW |
9 |
106,779,094 (GRCm39) |
splice site |
probably benign |
|
|
R0610:Dock3
|
UTSW |
9 |
106,900,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0731:Dock3
|
UTSW |
9 |
106,847,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dock3
|
UTSW |
9 |
106,846,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1350:Dock3
|
UTSW |
9 |
106,791,831 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1393:Dock3
|
UTSW |
9 |
106,788,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1424:Dock3
|
UTSW |
9 |
106,790,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1469:Dock3
|
UTSW |
9 |
106,832,908 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1539:Dock3
|
UTSW |
9 |
106,874,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1539:Dock3
|
UTSW |
9 |
106,829,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1571:Dock3
|
UTSW |
9 |
106,815,158 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1682:Dock3
|
UTSW |
9 |
106,851,040 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1795:Dock3
|
UTSW |
9 |
106,902,534 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1987:Dock3
|
UTSW |
9 |
106,985,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2000:Dock3
|
UTSW |
9 |
106,870,160 (GRCm39) |
splice site |
probably benign |
|
|
R2074:Dock3
|
UTSW |
9 |
106,870,662 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2114:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2265:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Dock3
|
UTSW |
9 |
106,818,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2370:Dock3
|
UTSW |
9 |
106,829,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2377:Dock3
|
UTSW |
9 |
106,773,090 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2385:Dock3
|
UTSW |
9 |
106,868,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2426:Dock3
|
UTSW |
9 |
106,791,740 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R3076:Dock3
|
UTSW |
9 |
106,818,725 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3122:Dock3
|
UTSW |
9 |
106,788,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4052:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4294:Dock3
|
UTSW |
9 |
106,807,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4623:Dock3
|
UTSW |
9 |
106,939,244 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4664:Dock3
|
UTSW |
9 |
106,870,743 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4705:Dock3
|
UTSW |
9 |
106,902,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Dock3
|
UTSW |
9 |
106,829,557 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4898:Dock3
|
UTSW |
9 |
106,870,171 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4898:Dock3
|
UTSW |
9 |
106,807,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Dock3
|
UTSW |
9 |
106,868,354 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4961:Dock3
|
UTSW |
9 |
106,818,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4986:Dock3
|
UTSW |
9 |
106,809,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5054:Dock3
|
UTSW |
9 |
106,815,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5065:Dock3
|
UTSW |
9 |
106,832,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Dock3
|
UTSW |
9 |
106,868,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5101:Dock3
|
UTSW |
9 |
106,846,980 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5135:Dock3
|
UTSW |
9 |
106,810,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Dock3
|
UTSW |
9 |
106,863,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5258:Dock3
|
UTSW |
9 |
106,874,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5273:Dock3
|
UTSW |
9 |
106,777,904 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5322:Dock3
|
UTSW |
9 |
106,779,028 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5482:Dock3
|
UTSW |
9 |
106,855,937 (GRCm39) |
nonsense |
probably null |
|
|
R5553:Dock3
|
UTSW |
9 |
106,868,309 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5631:Dock3
|
UTSW |
9 |
106,832,898 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5739:Dock3
|
UTSW |
9 |
106,850,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5838:Dock3
|
UTSW |
9 |
106,772,687 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R5888:Dock3
|
UTSW |
9 |
106,901,002 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5960:Dock3
|
UTSW |
9 |
106,788,554 (GRCm39) |
nonsense |
probably null |
|
|
R5974:Dock3
|
UTSW |
9 |
106,871,261 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6116:Dock3
|
UTSW |
9 |
106,809,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6162:Dock3
|
UTSW |
9 |
106,841,998 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6176:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6219:Dock3
|
UTSW |
9 |
106,872,080 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6238:Dock3
|
UTSW |
9 |
106,790,147 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6266:Dock3
|
UTSW |
9 |
106,841,952 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Dock3
|
UTSW |
9 |
106,785,631 (GRCm39) |
missense |
probably benign |
|
|
R6531:Dock3
|
UTSW |
9 |
106,844,415 (GRCm39) |
missense |
probably benign |
|
|
R6567:Dock3
|
UTSW |
9 |
106,773,946 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6572:Dock3
|
UTSW |
9 |
106,866,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6620:Dock3
|
UTSW |
9 |
106,815,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6726:Dock3
|
UTSW |
9 |
107,036,651 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Dock3
|
UTSW |
9 |
106,779,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7151:Dock3
|
UTSW |
9 |
106,841,916 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7320:Dock3
|
UTSW |
9 |
106,772,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7357:Dock3
|
UTSW |
9 |
106,882,568 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7423:Dock3
|
UTSW |
9 |
106,844,370 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7426:Dock3
|
UTSW |
9 |
106,772,782 (GRCm39) |
missense |
probably benign |
|
|
R7439:Dock3
|
UTSW |
9 |
106,900,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7452:Dock3
|
UTSW |
9 |
106,866,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7470:Dock3
|
UTSW |
9 |
106,882,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Dock3
|
UTSW |
9 |
106,785,700 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8047:Dock3
|
UTSW |
9 |
106,870,208 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8308:Dock3
|
UTSW |
9 |
106,790,371 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8837:Dock3
|
UTSW |
9 |
106,774,539 (GRCm39) |
missense |
probably benign |
|
|
R8862:Dock3
|
UTSW |
9 |
106,855,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8952:Dock3
|
UTSW |
9 |
106,850,958 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9230:Dock3
|
UTSW |
9 |
106,807,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9269:Dock3
|
UTSW |
9 |
106,818,522 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9272:Dock3
|
UTSW |
9 |
106,774,569 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9344:Dock3
|
UTSW |
9 |
106,870,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Dock3
|
UTSW |
9 |
106,901,035 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9764:Dock3
|
UTSW |
9 |
106,959,713 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9766:Dock3
|
UTSW |
9 |
106,788,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
X0023:Dock3
|
UTSW |
9 |
106,863,197 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCACACCTCAGACTTGCTATGGAC -3'
(R):5'- CAGCACAGGACACTTTGACCAAATG -3'
Sequencing Primer
(F):5'- CTCAGACTTGCTATGGACATACATTC -3'
(R):5'- TGACACTCACTATTGGAGCAG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation