Incidental Mutation 'IGL03022:Dynlt5'
ID 408013
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dynlt5
Ensembl Gene ENSMUSG00000028523
Gene Name dynein light chain Tctex-type 5
Synonyms 1700055O19Rik, Tctex1d1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.109) question?
Stock # IGL03022
Quality Score
Status
Chromosome 4
Chromosomal Location 102835900-102862419 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 102859714 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 85 (T85A)
Ref Sequence ENSEMBL: ENSMUSP00000128228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030248] [ENSMUST00000116317] [ENSMUST00000125417] [ENSMUST00000140654] [ENSMUST00000169211] [ENSMUST00000223169]
AlphaFold Q9D5I4
Predicted Effect probably benign
Transcript: ENSMUST00000030248
AA Change: T85A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000030248
Gene: ENSMUSG00000028523
AA Change: T85A

DomainStartEndE-ValueType
Pfam:Tctex-1 74 171 9.8e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000116317
AA Change: T85A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000112019
Gene: ENSMUSG00000028523
AA Change: T85A

DomainStartEndE-ValueType
Pfam:Tctex-1 72 172 7.7e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125417
AA Change: T28A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000117319
Gene: ENSMUSG00000028523
AA Change: T28A

DomainStartEndE-ValueType
Pfam:Tctex-1 17 114 4.5e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000140654
AA Change: T28A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000116692
Gene: ENSMUSG00000028523
AA Change: T28A

DomainStartEndE-ValueType
Pfam:Tctex-1 15 99 4.6e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148892
Predicted Effect probably benign
Transcript: ENSMUST00000169211
AA Change: T85A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000128228
Gene: ENSMUSG00000028523
AA Change: T85A

DomainStartEndE-ValueType
Pfam:Tctex-1 15 115 3.3e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000223169
AA Change: T89A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr2b G T 9: 119,256,587 (GRCm39) R40L probably benign Het
Asph T C 4: 9,517,668 (GRCm39) N402D possibly damaging Het
Brip1 T C 11: 85,968,776 (GRCm39) Y803C probably damaging Het
Cenpc1 T C 5: 86,170,234 (GRCm39) probably benign Het
Fam110b A G 4: 5,799,448 (GRCm39) M289V probably benign Het
Fam193b T C 13: 55,691,475 (GRCm39) N429S probably damaging Het
Folh1 T C 7: 86,395,379 (GRCm39) Y351C possibly damaging Het
Fryl G A 5: 73,216,726 (GRCm39) A2188V possibly damaging Het
Gtf2f1 C T 17: 57,317,971 (GRCm39) probably null Het
Gucy1a1 T C 3: 82,016,404 (GRCm39) K195E probably benign Het
H2-Oa T C 17: 34,313,023 (GRCm39) V100A probably damaging Het
Kcnu1 A T 8: 26,427,614 (GRCm39) K310N probably damaging Het
Mtss1 A G 15: 58,825,439 (GRCm39) S254P probably damaging Het
N4bp2l2 A G 5: 150,566,761 (GRCm39) S516P probably benign Het
Nrcam A G 12: 44,645,225 (GRCm39) D1139G probably damaging Het
Nxpe4 T C 9: 48,304,548 (GRCm39) S212P probably damaging Het
Or1ab2 A C 8: 72,863,968 (GRCm39) K186T probably damaging Het
Or5d47 C T 2: 87,804,341 (GRCm39) V223I probably benign Het
Or5p52 A T 7: 107,502,188 (GRCm39) H88L probably benign Het
Parp2 T C 14: 51,058,553 (GRCm39) Y528H probably damaging Het
Pdgfd T C 9: 6,288,495 (GRCm39) Y50H probably damaging Het
Prkaca A G 8: 84,721,976 (GRCm39) D329G possibly damaging Het
Rbbp8 A G 18: 11,858,559 (GRCm39) probably benign Het
Sele A G 1: 163,882,248 (GRCm39) T578A probably benign Het
Shroom2 A G X: 151,443,089 (GRCm39) V692A probably benign Het
Stxbp3 G A 3: 108,708,072 (GRCm39) L410F probably damaging Het
Tcaf1 C A 6: 42,655,060 (GRCm39) G553* probably null Het
Ttn G A 2: 76,576,862 (GRCm39) T24677M probably damaging Het
Vmn2r24 T A 6: 123,755,967 (GRCm39) L13H probably damaging Het
Zfp106 C A 2: 120,359,120 (GRCm39) probably benign Het
Zfp616 A G 11: 73,973,800 (GRCm39) D23G possibly damaging Het
Zfp84 T C 7: 29,474,759 (GRCm39) probably benign Het
Other mutations in Dynlt5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02650:Dynlt5 APN 4 102,845,803 (GRCm39) missense probably benign 0.00
IGL02813:Dynlt5 APN 4 102,849,769 (GRCm39) missense probably damaging 1.00
R0127:Dynlt5 UTSW 4 102,859,649 (GRCm39) splice site probably benign
R0685:Dynlt5 UTSW 4 102,859,735 (GRCm39) missense probably damaging 1.00
R4695:Dynlt5 UTSW 4 102,861,426 (GRCm39) missense probably damaging 0.98
R5274:Dynlt5 UTSW 4 102,859,768 (GRCm39) missense possibly damaging 0.85
R5433:Dynlt5 UTSW 4 102,859,700 (GRCm39) missense possibly damaging 0.75
R5950:Dynlt5 UTSW 4 102,861,447 (GRCm39) missense probably damaging 1.00
R6196:Dynlt5 UTSW 4 102,849,766 (GRCm39) missense possibly damaging 0.89
R6245:Dynlt5 UTSW 4 102,845,864 (GRCm39) missense probably benign 0.02
R9270:Dynlt5 UTSW 4 102,845,955 (GRCm39) splice site probably null
Posted On 2016-08-02