Incidental Mutation 'IGL03034:Or6c2'
ID |
408563 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Or6c2
|
Ensembl Gene |
ENSMUSG00000047626 |
Gene Name |
olfactory receptor family 6 subfamily C member 2 |
Synonyms |
MOR114-1, Olfr791, GA_x6K02T2PULF-11205096-11206034 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.108)
|
Stock # |
IGL03034
|
Quality Score |
|
Status
|
|
Chromosome |
10 |
Chromosomal Location |
129362098-129363036 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 129362527 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 144
(I144F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000150497
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000057477]
[ENSMUST00000217228]
|
AlphaFold |
Q8VGJ0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000057477
AA Change: I144F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000052722 Gene: ENSMUSG00000047626 AA Change: I144F
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
29 |
307 |
7.6e-45 |
PFAM |
Pfam:7TM_GPCR_Srsx
|
33 |
303 |
4.3e-6 |
PFAM |
Pfam:7tm_1
|
39 |
288 |
4.7e-24 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000217228
AA Change: I144F
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
5530401A14Rik |
C |
T |
11: 81,780,908 (GRCm39) |
|
probably benign |
Het |
Ablim2 |
A |
G |
5: 35,985,509 (GRCm39) |
T269A |
probably benign |
Het |
Asgr2 |
G |
T |
11: 69,989,089 (GRCm39) |
G178W |
probably damaging |
Het |
Chtf18 |
A |
G |
17: 25,946,320 (GRCm39) |
|
probably benign |
Het |
Cnmd |
C |
T |
14: 79,879,368 (GRCm39) |
A257T |
probably benign |
Het |
Cox7a1 |
A |
G |
7: 29,884,693 (GRCm39) |
|
probably benign |
Het |
Cpox |
C |
T |
16: 58,495,718 (GRCm39) |
T345M |
probably damaging |
Het |
Crisp1 |
T |
C |
17: 40,618,619 (GRCm39) |
T81A |
probably benign |
Het |
Dcc |
T |
A |
18: 71,708,214 (GRCm39) |
R501* |
probably null |
Het |
Dlx6 |
A |
C |
6: 6,863,807 (GRCm39) |
Q143P |
probably benign |
Het |
Dpp10 |
T |
A |
1: 123,269,348 (GRCm39) |
Y687F |
probably damaging |
Het |
Eif2b1 |
A |
G |
5: 124,709,894 (GRCm39) |
V228A |
probably benign |
Het |
Enpep |
T |
C |
3: 129,092,599 (GRCm39) |
D528G |
probably damaging |
Het |
Fbxo6 |
G |
A |
4: 148,230,579 (GRCm39) |
Q228* |
probably null |
Het |
Iars1 |
T |
A |
13: 49,843,965 (GRCm39) |
N146K |
possibly damaging |
Het |
Kctd9 |
T |
A |
14: 67,971,728 (GRCm39) |
S268T |
probably benign |
Het |
Kifap3 |
G |
A |
1: 163,715,846 (GRCm39) |
V749M |
probably benign |
Het |
Mdm4 |
T |
C |
1: 132,938,809 (GRCm39) |
D94G |
probably damaging |
Het |
Mllt10 |
T |
G |
2: 18,069,847 (GRCm39) |
M1R |
probably null |
Het |
Mtcl1 |
T |
C |
17: 66,651,193 (GRCm39) |
Y1424C |
probably damaging |
Het |
Mybpc2 |
A |
T |
7: 44,161,321 (GRCm39) |
I549N |
possibly damaging |
Het |
Myocd |
T |
C |
11: 65,109,511 (GRCm39) |
T87A |
probably benign |
Het |
Nr3c2 |
T |
G |
8: 77,914,267 (GRCm39) |
Y824* |
probably null |
Het |
Omg |
T |
A |
11: 79,392,947 (GRCm39) |
T304S |
possibly damaging |
Het |
Or4b1 |
A |
G |
2: 89,980,177 (GRCm39) |
Y58H |
probably damaging |
Het |
Or52p2 |
G |
A |
7: 102,237,147 (GRCm39) |
H268Y |
probably benign |
Het |
Or5an1b |
T |
C |
19: 12,300,018 (GRCm39) |
T58A |
possibly damaging |
Het |
Or5b97 |
T |
C |
19: 12,879,121 (GRCm39) |
T8A |
possibly damaging |
Het |
Pde3a |
G |
A |
6: 141,438,126 (GRCm39) |
|
probably benign |
Het |
Phf20l1 |
A |
G |
15: 66,469,252 (GRCm39) |
K129E |
probably damaging |
Het |
Phka2 |
G |
T |
X: 159,360,546 (GRCm39) |
E858* |
probably null |
Het |
Pp2d1 |
T |
C |
17: 53,815,081 (GRCm39) |
T548A |
possibly damaging |
Het |
Prr14l |
G |
A |
5: 32,984,782 (GRCm39) |
A1571V |
possibly damaging |
Het |
Rbms3 |
A |
G |
9: 117,080,879 (GRCm39) |
|
probably benign |
Het |
Sparcl1 |
T |
C |
5: 104,241,103 (GRCm39) |
E107G |
probably damaging |
Het |
Stra6l |
A |
G |
4: 45,885,392 (GRCm39) |
D620G |
probably benign |
Het |
Traf3ip2 |
A |
T |
10: 39,502,215 (GRCm39) |
K121I |
probably damaging |
Het |
Ttc34 |
T |
C |
4: 154,945,640 (GRCm39) |
S734P |
probably damaging |
Het |
Zfp953 |
C |
T |
13: 67,491,526 (GRCm39) |
C142Y |
probably damaging |
Het |
Zfp955b |
T |
A |
17: 33,521,142 (GRCm39) |
C204S |
probably benign |
Het |
|
Other mutations in Or6c2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01153:Or6c2
|
APN |
10 |
129,362,864 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL03281:Or6c2
|
APN |
10 |
129,362,272 (GRCm39) |
missense |
probably benign |
0.31 |
R0555:Or6c2
|
UTSW |
10 |
129,362,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1474:Or6c2
|
UTSW |
10 |
129,362,824 (GRCm39) |
missense |
probably benign |
0.03 |
R1638:Or6c2
|
UTSW |
10 |
129,362,488 (GRCm39) |
missense |
probably benign |
0.00 |
R1917:Or6c2
|
UTSW |
10 |
129,362,918 (GRCm39) |
missense |
probably damaging |
0.99 |
R1918:Or6c2
|
UTSW |
10 |
129,362,918 (GRCm39) |
missense |
probably damaging |
0.99 |
R1919:Or6c2
|
UTSW |
10 |
129,362,918 (GRCm39) |
missense |
probably damaging |
0.99 |
R2303:Or6c2
|
UTSW |
10 |
129,362,918 (GRCm39) |
missense |
probably benign |
0.10 |
R3113:Or6c2
|
UTSW |
10 |
129,363,012 (GRCm39) |
missense |
probably benign |
0.08 |
R3929:Or6c2
|
UTSW |
10 |
129,362,100 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R4704:Or6c2
|
UTSW |
10 |
129,362,171 (GRCm39) |
missense |
possibly damaging |
0.90 |
R4831:Or6c2
|
UTSW |
10 |
129,362,449 (GRCm39) |
missense |
probably damaging |
1.00 |
R5207:Or6c2
|
UTSW |
10 |
129,362,773 (GRCm39) |
missense |
probably benign |
0.08 |
R5313:Or6c2
|
UTSW |
10 |
129,362,950 (GRCm39) |
missense |
probably damaging |
1.00 |
R5644:Or6c2
|
UTSW |
10 |
129,362,972 (GRCm39) |
missense |
probably damaging |
1.00 |
R5661:Or6c2
|
UTSW |
10 |
129,362,618 (GRCm39) |
missense |
probably benign |
0.45 |
R5894:Or6c2
|
UTSW |
10 |
129,362,357 (GRCm39) |
missense |
probably damaging |
0.98 |
R6988:Or6c2
|
UTSW |
10 |
129,362,542 (GRCm39) |
missense |
probably benign |
0.02 |
R6996:Or6c2
|
UTSW |
10 |
129,362,732 (GRCm39) |
missense |
probably damaging |
1.00 |
R7380:Or6c2
|
UTSW |
10 |
129,362,530 (GRCm39) |
missense |
probably benign |
|
R7539:Or6c2
|
UTSW |
10 |
129,362,974 (GRCm39) |
nonsense |
probably null |
|
R7552:Or6c2
|
UTSW |
10 |
129,362,429 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7635:Or6c2
|
UTSW |
10 |
129,362,551 (GRCm39) |
missense |
probably benign |
0.00 |
R8084:Or6c2
|
UTSW |
10 |
129,362,809 (GRCm39) |
missense |
probably damaging |
1.00 |
R8260:Or6c2
|
UTSW |
10 |
129,362,957 (GRCm39) |
missense |
possibly damaging |
0.55 |
R8755:Or6c2
|
UTSW |
10 |
129,362,332 (GRCm39) |
missense |
possibly damaging |
0.60 |
X0066:Or6c2
|
UTSW |
10 |
129,362,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Posted On |
2016-08-02 |