Incidental Mutation 'IGL03035:Ptgds'
ID 408624
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ptgds
Ensembl Gene ENSMUSG00000015090
Gene Name prostaglandin D2 synthase (brain)
Synonyms L-PGDS, PGD2, Ptgs3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # IGL03035
Quality Score
Status
Chromosome 2
Chromosomal Location 25356721-25360058 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25359622 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 22 (T22A)
Ref Sequence ENSEMBL: ENSMUSP00000109897 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015234] [ENSMUST00000114251] [ENSMUST00000114259]
AlphaFold O09114
Predicted Effect probably benign
Transcript: ENSMUST00000015234
AA Change: T22A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000015234
Gene: ENSMUSG00000015090
AA Change: T22A

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
Pfam:Lipocalin 40 184 4.2e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114251
AA Change: T22A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000109889
Gene: ENSMUSG00000015090
AA Change: T22A

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
Pfam:Lipocalin 40 184 4.2e-35 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114259
AA Change: T22A

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000109897
Gene: ENSMUSG00000015090
AA Change: T22A

DomainStartEndE-ValueType
low complexity region 4 18 N/A INTRINSIC
Pfam:Lipocalin 40 184 4.2e-35 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137417
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144016
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for one knock-out allele fail to exhibit PGE2- and bicuculline-induced allodynia and exhibit decreased susceptibility to IgE-induced PCA. Mice homozygous for another knock-out allele show normal induction of muscle injury after reperfusion of ischemic skeletal muscle. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc9 A G 6: 142,573,319 (GRCm39) L1004P probably damaging Het
Adgrf5 T C 17: 43,741,518 (GRCm39) I385T possibly damaging Het
Alpk3 T C 7: 80,728,352 (GRCm39) V494A probably benign Het
Camta2 C A 11: 70,562,335 (GRCm39) E1021* probably null Het
Ccdc6 T A 10: 70,018,006 (GRCm39) S334T probably benign Het
Cd84 T C 1: 171,679,601 (GRCm39) V93A probably damaging Het
Ceacam20 T C 7: 19,711,833 (GRCm39) probably null Het
Crip2 A C 12: 113,107,745 (GRCm39) T103P probably benign Het
Cyp4f14 T A 17: 33,133,608 (GRCm39) T83S probably benign Het
Dapk1 T A 13: 60,864,587 (GRCm39) V127D probably damaging Het
Dnah7c A G 1: 46,563,277 (GRCm39) E609G probably benign Het
Dscam T A 16: 96,621,170 (GRCm39) I513F possibly damaging Het
Ell2 T A 13: 75,911,767 (GRCm39) L351* probably null Het
Emcn G T 3: 137,078,612 (GRCm39) probably null Het
Fdft1 A T 14: 63,400,838 (GRCm39) C98* probably null Het
Fer1l4 A G 2: 155,864,526 (GRCm39) S1663P possibly damaging Het
Flt4 C A 11: 49,536,724 (GRCm39) Y1231* probably null Het
Gatb A G 3: 85,509,254 (GRCm39) K139E probably damaging Het
Gtf2a1 C A 12: 91,539,411 (GRCm39) probably benign Het
Gtf3c2 A C 5: 31,323,358 (GRCm39) V574G possibly damaging Het
Heatr1 T C 13: 12,428,100 (GRCm39) probably benign Het
Homer2 T A 7: 81,274,026 (GRCm39) T57S possibly damaging Het
Ice2 C A 9: 69,332,970 (GRCm39) F825L probably benign Het
Lepr C A 4: 101,622,177 (GRCm39) L370I probably damaging Het
Nalcn G A 14: 123,515,630 (GRCm39) Q1724* probably null Het
Nufip1 A G 14: 76,353,258 (GRCm39) D222G probably damaging Het
Or4f4b T C 2: 111,314,168 (GRCm39) V159A probably benign Het
Prl3b1 A G 13: 27,433,516 (GRCm39) probably benign Het
Ptbp3 A T 4: 59,477,218 (GRCm39) M393K probably benign Het
Rapgef2 T A 3: 79,001,731 (GRCm39) H282L probably damaging Het
Rars2 T C 4: 34,656,865 (GRCm39) probably null Het
Rnf213 G A 11: 119,336,452 (GRCm39) probably benign Het
Ros1 C A 10: 51,952,080 (GRCm39) probably benign Het
Slx4ip A G 2: 136,909,623 (GRCm39) D206G possibly damaging Het
Sprr1a T A 3: 92,391,884 (GRCm39) D39V probably benign Het
Stab1 A G 14: 30,869,726 (GRCm39) V1442A probably benign Het
Tbx3 C A 5: 119,821,161 (GRCm39) probably benign Het
Ubl3 A G 5: 148,442,947 (GRCm39) *118Q probably null Het
Vmn2r55 G A 7: 12,404,743 (GRCm39) S220L probably benign Het
Vps36 A G 8: 22,708,431 (GRCm39) K362E probably benign Het
Zfp268 C A 4: 145,348,802 (GRCm39) Q80K possibly damaging Het
Other mutations in Ptgds
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02164:Ptgds APN 2 25,359,124 (GRCm39) missense probably damaging 0.99
IGL03036:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
IGL03117:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
IGL03352:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
IGL03354:Ptgds APN 2 25,359,622 (GRCm39) missense probably benign 0.06
R0780:Ptgds UTSW 2 25,358,104 (GRCm39) missense possibly damaging 0.90
R0885:Ptgds UTSW 2 25,357,357 (GRCm39) missense possibly damaging 0.80
R4820:Ptgds UTSW 2 25,359,058 (GRCm39) missense probably benign 0.02
R7000:Ptgds UTSW 2 25,357,828 (GRCm39) critical splice donor site probably null
R7522:Ptgds UTSW 2 25,357,920 (GRCm39) missense probably benign 0.38
R8401:Ptgds UTSW 2 25,359,669 (GRCm39) missense unknown
R9794:Ptgds UTSW 2 25,359,129 (GRCm39) missense probably benign 0.05
Posted On 2016-08-02