Incidental Mutation 'IGL03036:Zfr2'
ID 408700
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfr2
Ensembl Gene ENSMUSG00000034949
Gene Name zinc finger RNA binding protein 2
Synonyms 2010013I23Rik, 9130206N08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL03036
Quality Score
Status
Chromosome 10
Chromosomal Location 81068989-81087957 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 81077985 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 271 (M271L)
Ref Sequence ENSEMBL: ENSMUSP00000113913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117798] [ENSMUST00000144087]
AlphaFold E9Q5M4
Predicted Effect probably benign
Transcript: ENSMUST00000117798
AA Change: M271L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000113913
Gene: ENSMUSG00000034949
AA Change: M271L

DomainStartEndE-ValueType
low complexity region 16 23 N/A INTRINSIC
low complexity region 44 62 N/A INTRINSIC
low complexity region 123 163 N/A INTRINSIC
ZnF_U1 202 236 3.58e-5 SMART
ZnF_C2H2 205 229 7.68e0 SMART
ZnF_U1 249 283 3.78e-4 SMART
ZnF_C2H2 252 276 4.12e0 SMART
ZnF_U1 397 431 3.78e-4 SMART
ZnF_C2H2 400 424 1.99e0 SMART
low complexity region 484 508 N/A INTRINSIC
DZF 585 837 2.06e-129 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127526
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128182
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132174
Predicted Effect probably benign
Transcript: ENSMUST00000144087
SMART Domains Protein: ENSMUSP00000115001
Gene: ENSMUSG00000034949

DomainStartEndE-ValueType
low complexity region 33 51 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd17a A T 10: 80,421,534 (GRCm39) Y145* probably null Het
Afdn T G 17: 14,108,350 (GRCm39) I1291S probably benign Het
Arfgap3 T G 15: 83,191,127 (GRCm39) I16L possibly damaging Het
Bbs12 T A 3: 37,373,343 (GRCm39) H45Q possibly damaging Het
Brpf3 T C 17: 29,043,022 (GRCm39) L1021P possibly damaging Het
Cep170 A G 1: 176,596,903 (GRCm39) S485P possibly damaging Het
Cgref1 A T 5: 31,090,937 (GRCm39) N292K probably damaging Het
Chst3 A T 10: 60,022,261 (GRCm39) Y195* probably null Het
Clmn T C 12: 104,740,782 (GRCm39) Y125C probably damaging Het
Col13a1 A G 10: 61,729,692 (GRCm39) probably null Het
Cpeb3 A T 19: 37,002,348 (GRCm39) I688N probably damaging Het
Cpn2 A T 16: 30,079,647 (GRCm39) L18H probably benign Het
Crybg3 T A 16: 59,375,542 (GRCm39) H1904L possibly damaging Het
Csde1 C T 3: 102,951,155 (GRCm39) P249S probably damaging Het
Dcaf1 T C 9: 106,721,339 (GRCm39) L377P probably damaging Het
Dmwd A T 7: 18,815,054 (GRCm39) K568M probably damaging Het
Dsg2 T C 18: 20,712,134 (GRCm39) I90T probably damaging Het
Dytn A G 1: 63,680,281 (GRCm39) I426T probably damaging Het
Edc4 G A 8: 106,613,943 (GRCm39) probably null Het
Elac1 G T 18: 73,871,985 (GRCm39) Q337K probably benign Het
Exd2 G T 12: 80,536,185 (GRCm39) A272S probably damaging Het
F13b A G 1: 139,435,853 (GRCm39) I220V possibly damaging Het
Fblim1 G T 4: 141,310,435 (GRCm39) R276S possibly damaging Het
Fn1 A C 1: 71,668,932 (GRCm39) L671R probably damaging Het
Frem1 A T 4: 82,877,576 (GRCm39) F1334I possibly damaging Het
H2-T23 T A 17: 36,343,249 (GRCm39) I43F possibly damaging Het
Hp1bp3 G A 4: 137,956,043 (GRCm39) G202D probably damaging Het
Kdm5b A G 1: 134,536,675 (GRCm39) M632V probably damaging Het
Klra5 T A 6: 129,885,830 (GRCm39) S20C probably damaging Het
Lancl1 A T 1: 67,046,074 (GRCm39) C276S probably damaging Het
Lect2 A G 13: 56,690,520 (GRCm39) *152Q probably null Het
Maff C A 15: 79,241,658 (GRCm39) S25* probably null Het
Mtr A G 13: 12,262,263 (GRCm39) L171P probably damaging Het
Ndufs1 A T 1: 63,202,855 (GRCm39) Y236* probably null Het
Neb A C 2: 52,134,165 (GRCm39) Y3273D probably damaging Het
Nup133 A T 8: 124,673,333 (GRCm39) I66K probably benign Het
Or4c110 T C 2: 88,832,459 (GRCm39) M58V possibly damaging Het
Psmd14 A G 2: 61,614,205 (GRCm39) Y200C probably damaging Het
Ptgds T C 2: 25,359,622 (GRCm39) T22A probably benign Het
Ptk2b T A 14: 66,411,344 (GRCm39) probably benign Het
Pum3 G A 19: 27,398,713 (GRCm39) T279M probably damaging Het
Rabl6 C T 2: 25,474,868 (GRCm39) G614D probably benign Het
Ripk3 T C 14: 56,024,796 (GRCm39) D128G probably benign Het
Serinc4 A T 2: 121,270,039 (GRCm39) probably benign Het
Slco1a8 T G 6: 141,954,333 (GRCm39) I47L possibly damaging Het
Sorbs2 T C 8: 46,235,902 (GRCm39) S322P probably benign Het
Spmap2l A C 5: 77,164,197 (GRCm39) K67Q possibly damaging Het
Srebf1 A T 11: 60,111,284 (GRCm39) I29N possibly damaging Het
Stk38l T C 6: 146,670,372 (GRCm39) L238S probably damaging Het
Supt20 T A 3: 54,616,723 (GRCm39) C298* probably null Het
Tbc1d19 A G 5: 54,054,389 (GRCm39) D459G probably damaging Het
Ulk2 A T 11: 61,725,660 (GRCm39) L139M probably damaging Het
Unc13b A G 4: 43,235,249 (GRCm39) N3279S probably damaging Het
Ush2a A G 1: 188,596,818 (GRCm39) R3853G possibly damaging Het
Usp7 C T 16: 8,556,078 (GRCm39) M24I probably benign Het
Vil1 A G 1: 74,458,771 (GRCm39) T131A probably damaging Het
Vmn2r2 C T 3: 64,024,321 (GRCm39) M753I probably benign Het
Vmn2r74 A T 7: 85,601,900 (GRCm39) Y579* probably null Het
Zdhhc3 A T 9: 122,929,582 (GRCm39) Y18N probably damaging Het
Zfp609 C T 9: 65,609,927 (GRCm39) S1012N possibly damaging Het
Other mutations in Zfr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00672:Zfr2 APN 10 81,077,919 (GRCm39) missense probably damaging 0.96
IGL01622:Zfr2 APN 10 81,087,193 (GRCm39) missense probably benign
IGL01623:Zfr2 APN 10 81,087,193 (GRCm39) missense probably benign
IGL02719:Zfr2 APN 10 81,080,546 (GRCm39) missense probably damaging 1.00
R0302:Zfr2 UTSW 10 81,087,170 (GRCm39) unclassified probably benign
R0837:Zfr2 UTSW 10 81,081,242 (GRCm39) missense probably damaging 1.00
R1557:Zfr2 UTSW 10 81,083,225 (GRCm39) missense probably benign 0.01
R1714:Zfr2 UTSW 10 81,080,583 (GRCm39) missense probably damaging 1.00
R1737:Zfr2 UTSW 10 81,077,919 (GRCm39) missense probably damaging 0.96
R1991:Zfr2 UTSW 10 81,078,686 (GRCm39) missense possibly damaging 0.86
R2134:Zfr2 UTSW 10 81,078,735 (GRCm39) missense probably damaging 1.00
R2148:Zfr2 UTSW 10 81,077,950 (GRCm39) missense probably benign 0.13
R2150:Zfr2 UTSW 10 81,077,950 (GRCm39) missense probably benign 0.13
R3703:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R3704:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R3705:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R3715:Zfr2 UTSW 10 81,081,913 (GRCm39) missense probably benign 0.40
R4301:Zfr2 UTSW 10 81,078,018 (GRCm39) unclassified probably benign
R4654:Zfr2 UTSW 10 81,087,083 (GRCm39) splice site probably null
R4811:Zfr2 UTSW 10 81,079,547 (GRCm39) missense probably benign 0.07
R5290:Zfr2 UTSW 10 81,082,544 (GRCm39) frame shift probably null
R5781:Zfr2 UTSW 10 81,079,547 (GRCm39) missense probably benign 0.07
R7114:Zfr2 UTSW 10 81,080,559 (GRCm39) missense probably damaging 1.00
R8192:Zfr2 UTSW 10 81,078,649 (GRCm39) missense possibly damaging 0.83
R8359:Zfr2 UTSW 10 81,078,653 (GRCm39) missense possibly damaging 0.57
R8389:Zfr2 UTSW 10 81,081,323 (GRCm39) missense probably benign
R8827:Zfr2 UTSW 10 81,078,619 (GRCm39) missense probably benign 0.00
R8953:Zfr2 UTSW 10 81,084,271 (GRCm39) missense probably damaging 0.99
R9086:Zfr2 UTSW 10 81,076,029 (GRCm39) missense probably damaging 0.96
R9189:Zfr2 UTSW 10 81,080,496 (GRCm39) missense probably damaging 1.00
R9487:Zfr2 UTSW 10 81,075,969 (GRCm39) missense probably benign 0.33
R9592:Zfr2 UTSW 10 81,069,580 (GRCm39) missense unknown
R9645:Zfr2 UTSW 10 81,084,252 (GRCm39) nonsense probably null
X0063:Zfr2 UTSW 10 81,078,791 (GRCm39) critical splice donor site probably null
Z1177:Zfr2 UTSW 10 81,081,918 (GRCm39) nonsense probably null
Posted On 2016-08-02