Incidental Mutation 'IGL03037:Hnrnpa0'
ID 408748
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Hnrnpa0
Ensembl Gene ENSMUSG00000007836
Gene Name heterogeneous nuclear ribonucleoprotein A0
Synonyms Hnrpa0, 3010025E17Rik, 1110055B05Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.833) question?
Stock # IGL03037
Quality Score
Status
Chromosome 13
Chromosomal Location 58273693-58276370 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58275767 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 121 (F121L)
Ref Sequence ENSEMBL: ENSMUSP00000007980 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000007980]
AlphaFold Q9CX86
Predicted Effect probably damaging
Transcript: ENSMUST00000007980
AA Change: F121L

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000007980
Gene: ENSMUSG00000007836
AA Change: F121L

DomainStartEndE-ValueType
RRM 8 80 3.62e-21 SMART
RRM 99 171 1.91e-20 SMART
low complexity region 181 208 N/A INTRINSIC
low complexity region 216 262 N/A INTRINSIC
low complexity region 266 304 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind RNAs, followed by a glycine-rich C-terminus. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl11 T C 9: 107,807,294 (GRCm39) L539P probably damaging Het
Adam23 A T 1: 63,610,176 (GRCm39) Q726L possibly damaging Het
Ago1 T C 4: 126,355,587 (GRCm39) E74G probably benign Het
Atp6v1d C A 12: 78,904,122 (GRCm39) probably benign Het
Bltp1 C A 3: 37,023,356 (GRCm39) S2227R probably benign Het
Bltp1 T C 3: 37,023,357 (GRCm39) S2229P probably damaging Het
Cadm4 T A 7: 24,200,220 (GRCm39) L243Q probably damaging Het
Camsap2 C A 1: 136,202,595 (GRCm39) L1274F probably damaging Het
Car10 A G 11: 92,991,044 (GRCm39) probably benign Het
Catsperd A T 17: 56,948,583 (GRCm39) D186V possibly damaging Het
Cdc42bpg A G 19: 6,361,230 (GRCm39) Y285C probably damaging Het
Cenpi T A X: 133,250,017 (GRCm39) C599S possibly damaging Het
Cln8 A T 8: 14,944,679 (GRCm39) probably benign Het
Cnksr1 T C 4: 133,962,417 (GRCm39) probably null Het
Cripto C A 9: 110,772,288 (GRCm39) W36L probably benign Het
Ddx5 T C 11: 106,672,930 (GRCm39) N532D possibly damaging Het
Dock11 G T X: 35,310,699 (GRCm39) probably benign Het
Dock8 A G 19: 25,063,545 (GRCm39) E249G probably benign Het
Espnl T C 1: 91,269,643 (GRCm39) V393A probably benign Het
Fhip1b A T 7: 105,028,293 (GRCm39) H885Q probably benign Het
Frrs1 T C 3: 116,696,116 (GRCm39) probably benign Het
Fstl4 C A 11: 53,059,050 (GRCm39) A503D possibly damaging Het
Gda T A 19: 21,411,673 (GRCm39) I42L possibly damaging Het
Gprc5d C A 6: 135,093,319 (GRCm39) C196F probably damaging Het
Hsd3b7 C T 7: 127,400,322 (GRCm39) H24Y probably damaging Het
Ift140 T C 17: 25,311,368 (GRCm39) S1188P probably benign Het
Lyl1 C T 8: 85,429,300 (GRCm39) P3L possibly damaging Het
Mcemp1 C A 8: 3,717,055 (GRCm39) Y65* probably null Het
Mmp16 C T 4: 17,996,222 (GRCm39) P104S probably damaging Het
Mpst C A 15: 78,294,798 (GRCm39) R177S probably benign Het
Nek1 A T 8: 61,487,086 (GRCm39) T279S probably benign Het
Or1q1 C T 2: 36,887,560 (GRCm39) T246I probably benign Het
Or1x2 A T 11: 50,918,117 (GRCm39) Y96F probably damaging Het
Or4c11b A G 2: 88,625,299 (GRCm39) Y191C probably damaging Het
Or7g18 T A 9: 18,786,668 (GRCm39) I12N probably damaging Het
Pard3 A T 8: 128,032,975 (GRCm39) T190S probably benign Het
Pik3r4 A G 9: 105,528,012 (GRCm39) D455G probably damaging Het
Piwil4 T C 9: 14,616,308 (GRCm39) I756V possibly damaging Het
Pkhd1 A G 1: 20,592,923 (GRCm39) L1730P probably benign Het
Pnpla3 T C 15: 84,056,960 (GRCm39) I155T probably damaging Het
Prmt8 T C 6: 127,680,940 (GRCm39) Y243C possibly damaging Het
Rbfox1 T A 16: 7,110,147 (GRCm39) probably benign Het
Rps6ka2 G A 17: 7,521,849 (GRCm39) probably null Het
Scaf8 A G 17: 3,240,496 (GRCm39) K623E probably damaging Het
Slc26a4 A T 12: 31,581,686 (GRCm39) probably benign Het
Slfn8 T A 11: 82,894,078 (GRCm39) I854F probably damaging Het
Smarca4 T C 9: 21,544,231 (GRCm39) probably benign Het
Sos1 T C 17: 80,727,758 (GRCm39) D775G probably damaging Het
Spag17 G A 3: 99,979,486 (GRCm39) probably null Het
Spata31d1d T A 13: 59,873,947 (GRCm39) E1196V possibly damaging Het
Sqle T A 15: 59,193,246 (GRCm39) Y208N probably damaging Het
Tcl1b5 C T 12: 105,145,273 (GRCm39) T79M probably benign Het
Tenm3 A G 8: 48,751,913 (GRCm39) F959L possibly damaging Het
Tnfrsf19 T A 14: 61,261,721 (GRCm39) K26I possibly damaging Het
Trappc10 A T 10: 78,034,869 (GRCm39) probably benign Het
Trim80 T C 11: 115,332,419 (GRCm39) W204R possibly damaging Het
Trpm3 A G 19: 22,866,776 (GRCm39) T536A possibly damaging Het
Ttbk1 G A 17: 46,757,256 (GRCm39) T1126I probably benign Het
Uaca A G 9: 60,748,147 (GRCm39) D37G probably damaging Het
Ube3a T C 7: 58,896,971 (GRCm39) probably benign Het
Ubqln2 C T X: 152,282,692 (GRCm39) Q415* probably null Het
Ugp2 T A 11: 21,282,540 (GRCm39) K151* probably null Het
Wasf1 A G 10: 40,806,654 (GRCm39) K99R probably benign Het
Wnt4 C T 4: 137,016,472 (GRCm39) T42M possibly damaging Het
Zfp54 T A 17: 21,650,477 (GRCm39) D17E probably damaging Het
Other mutations in Hnrnpa0
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2092:Hnrnpa0 UTSW 13 58,275,614 (GRCm39) missense probably damaging 1.00
R3870:Hnrnpa0 UTSW 13 58,275,713 (GRCm39) missense probably damaging 1.00
R4432:Hnrnpa0 UTSW 13 58,275,751 (GRCm39) missense probably benign 0.43
R8260:Hnrnpa0 UTSW 13 58,275,228 (GRCm39) nonsense probably null
Posted On 2016-08-02