Incidental Mutation 'IGL03039:Setd3'
ID408840
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Setd3
Ensembl Gene ENSMUSG00000056770
Gene NameSET domain containing 3
Synonyms2610305M23Rik, 2610102I01Rik, D12Ertd771e
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03039
Quality Score
Status
Chromosome12
Chromosomal Location108106431-108179314 bp(-) (GRCm38)
Type of Mutationsplice site (3 bp from exon)
DNA Base Change (assembly) T to C at 108162970 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000122520 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071095] [ENSMUST00000109879] [ENSMUST00000125916] [ENSMUST00000132682] [ENSMUST00000147466]
Predicted Effect probably null
Transcript: ENSMUST00000071095
SMART Domains Protein: ENSMUSP00000066413
Gene: ENSMUSG00000056770

DomainStartEndE-ValueType
Pfam:SET 105 314 2.1e-12 PFAM
Pfam:Rubis-subs-bind 345 475 3.7e-31 PFAM
low complexity region 565 577 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000109879
SMART Domains Protein: ENSMUSP00000105505
Gene: ENSMUSG00000056770

DomainStartEndE-ValueType
Pfam:SET 105 287 6.5e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000125916
SMART Domains Protein: ENSMUSP00000122520
Gene: ENSMUSG00000056770

DomainStartEndE-ValueType
PDB:3SMT|A 9 155 1e-100 PDB
Blast:SET 101 155 5e-32 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000132682
SMART Domains Protein: ENSMUSP00000123159
Gene: ENSMUSG00000056770

DomainStartEndE-ValueType
PDB:3SMT|A 2 58 3e-30 PDB
SCOP:d1epua_ 50 79 6e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000147466
SMART Domains Protein: ENSMUSP00000121406
Gene: ENSMUSG00000056770

DomainStartEndE-ValueType
PDB:3SMT|A 2 58 3e-30 PDB
SCOP:d1epua_ 50 79 6e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000169951
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330182L06Rik A G 5: 9,418,055 E241G probably benign Het
Adam6b T C 12: 113,490,882 C440R probably damaging Het
Agbl2 A G 2: 90,801,222 D308G possibly damaging Het
Cfh G T 1: 140,136,261 Q408K possibly damaging Het
Chrna7 A G 7: 63,148,592 L114P probably damaging Het
Defa35 G A 8: 21,065,823 C66Y probably damaging Het
Dnah12 C A 14: 26,724,512 Q743K probably benign Het
Esco2 T C 14: 65,831,418 K148E probably damaging Het
Gm17079 T A 14: 51,693,061 E109V probably damaging Het
Herc2 T A 7: 56,169,021 probably benign Het
Igkv1-88 T C 6: 68,862,292 Y112C possibly damaging Het
Igkv4-50 T C 6: 69,701,058 R21G probably benign Het
Kbtbd11 A G 8: 15,027,467 D22G probably benign Het
Kcnb2 A G 1: 15,711,211 D769G probably benign Het
Kdm2b C A 5: 122,881,671 W817L probably benign Het
Myo18b A G 5: 112,840,771 V983A probably damaging Het
Nr1d2 A T 14: 18,215,184 M276K probably benign Het
Olfr1129 T A 2: 87,575,192 M36K probably benign Het
Olfr320 T A 11: 58,684,011 V46D probably damaging Het
Phf20 T C 2: 156,298,541 Y712H probably damaging Het
Phkg2 T A 7: 127,579,694 Y27* probably null Het
Pomt2 C A 12: 87,110,366 L726F probably benign Het
Skint4 T C 4: 112,124,650 V272A probably benign Het
Slc41a2 A G 10: 83,283,858 Y347H probably benign Het
Slc45a2 T C 15: 11,012,687 S259P probably benign Het
Tgfbr3 A C 5: 107,177,799 probably benign Het
Tgfbrap1 A T 1: 43,075,928 I4N possibly damaging Het
Trh C A 6: 92,243,728 R51L probably damaging Het
Vars2 A T 17: 35,664,121 V312E probably damaging Het
Wdfy2 T C 14: 62,948,720 V268A probably benign Het
Other mutations in Setd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00971:Setd3 APN 12 108160237 missense probably damaging 1.00
IGL01365:Setd3 APN 12 108157906 missense probably damaging 1.00
IGL02031:Setd3 APN 12 108163030 missense probably damaging 1.00
IGL02826:Setd3 APN 12 108112124 unclassified probably benign
IGL02878:Setd3 APN 12 108108555 critical splice donor site probably null
R0332:Setd3 UTSW 12 108107579 missense probably benign
R1644:Setd3 UTSW 12 108113344 missense possibly damaging 0.88
R1776:Setd3 UTSW 12 108165161 missense probably damaging 1.00
R2018:Setd3 UTSW 12 108118254 missense probably damaging 1.00
R2025:Setd3 UTSW 12 108160267 missense probably damaging 1.00
R2041:Setd3 UTSW 12 108113392 missense possibly damaging 0.84
R2058:Setd3 UTSW 12 108107341 missense probably benign 0.03
R2206:Setd3 UTSW 12 108107285 missense probably benign 0.11
R2207:Setd3 UTSW 12 108107285 missense probably benign 0.11
R3973:Setd3 UTSW 12 108165158 missense possibly damaging 0.93
R3976:Setd3 UTSW 12 108165158 missense possibly damaging 0.93
R3978:Setd3 UTSW 12 108157942 missense possibly damaging 0.63
R4684:Setd3 UTSW 12 108108690 missense probably benign 0.05
R4965:Setd3 UTSW 12 108113371 missense probably benign 0.29
R5691:Setd3 UTSW 12 108160285 missense probably benign 0.19
R5990:Setd3 UTSW 12 108160335 missense probably benign
R6198:Setd3 UTSW 12 108165168 missense possibly damaging 0.66
R6241:Setd3 UTSW 12 108157855 missense probably benign 0.24
R6428:Setd3 UTSW 12 108113338 missense probably damaging 0.99
X0052:Setd3 UTSW 12 108107665 missense probably benign 0.37
Posted On2016-08-02