Incidental Mutation 'IGL03051:Rps6ka5'
ID 409077
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rps6ka5
Ensembl Gene ENSMUSG00000021180
Gene Name ribosomal protein S6 kinase, polypeptide 5
Synonyms 3110005L17Rik, MSK1, 6330404E13Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03051
Quality Score
Status
Chromosome 12
Chromosomal Location 100514692-100691693 bp(-) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to C at 100582250 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152481 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000043599] [ENSMUST00000222731]
AlphaFold Q8C050
Predicted Effect probably null
Transcript: ENSMUST00000043599
SMART Domains Protein: ENSMUSP00000042987
Gene: ENSMUSG00000021180

DomainStartEndE-ValueType
low complexity region 2 22 N/A INTRINSIC
S_TKc 48 317 1.08e-101 SMART
S_TK_X 318 378 2.45e-13 SMART
S_TKc 425 751 1.1e-75 SMART
low complexity region 812 832 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221246
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221379
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222347
Predicted Effect noncoding transcript
Transcript: ENSMUST00000222403
Predicted Effect probably null
Transcript: ENSMUST00000222731
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a mutant allele exhibit altered response to cocaine including decreased hyperlocomotor activity and sensitization at a lower dose. Mice homozygous for a kinase dead allele exhibit altered experience-dependent synaptic plasticity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 G T 6: 86,964,283 (GRCm39) probably benign Het
Abhd14a A T 9: 106,321,128 (GRCm39) F76I possibly damaging Het
Acvr1b A G 15: 101,100,959 (GRCm39) R374G probably damaging Het
Akap13 T A 7: 75,260,233 (GRCm39) C149* probably null Het
Appbp2 A T 11: 85,082,565 (GRCm39) D555E possibly damaging Het
Arhgap25 T C 6: 87,472,896 (GRCm39) Q87R probably null Het
Baz1b T A 5: 135,246,079 (GRCm39) N509K probably benign Het
Ccn4 T A 15: 66,778,399 (GRCm39) C73* probably null Het
Ces5a C A 8: 94,255,226 (GRCm39) G156C probably damaging Het
Chtf18 G A 17: 25,939,938 (GRCm39) R723W probably damaging Het
Clec4e A G 6: 123,266,692 (GRCm39) S6P probably benign Het
Dennd4a A G 9: 64,769,696 (GRCm39) I468V probably damaging Het
Epb41l4a A T 18: 34,007,825 (GRCm39) Y233N probably damaging Het
Fam210b C T 2: 172,194,612 (GRCm39) H155Y probably benign Het
Frmd4b A T 6: 97,272,943 (GRCm39) C770* probably null Het
Gpa33 A G 1: 165,992,790 (GRCm39) H301R probably benign Het
Gpr39 T A 1: 125,605,485 (GRCm39) C138S probably damaging Het
Gtf2i T A 5: 134,271,768 (GRCm39) K858* probably null Het
Ighv7-1 A T 12: 113,860,576 (GRCm39) probably benign Het
Iglv1 T C 16: 18,903,973 (GRCm39) T49A possibly damaging Het
Kif17 A C 4: 138,016,565 (GRCm39) D416A probably damaging Het
Mib2 T C 4: 155,741,747 (GRCm39) T431A probably damaging Het
Mpz G A 1: 170,986,380 (GRCm39) R98H probably damaging Het
Naa16 T C 14: 79,606,522 (GRCm39) E337G probably benign Het
Odam G A 5: 88,040,335 (GRCm39) probably benign Het
Or1e1f T A 11: 73,855,860 (GRCm39) L142H probably benign Het
Parp2 T C 14: 51,056,805 (GRCm39) probably benign Het
Pcdh7 T G 5: 58,286,415 (GRCm39) S1164A probably damaging Het
Pkp4 G T 2: 59,142,106 (GRCm39) A470S probably benign Het
Plin4 A T 17: 56,412,417 (GRCm39) M538K possibly damaging Het
Prex2 T C 1: 11,212,889 (GRCm39) V624A probably damaging Het
Simc1 T C 13: 54,674,036 (GRCm39) S795P probably benign Het
Slc35b4 A T 6: 34,137,406 (GRCm39) probably null Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Syt14 T C 1: 192,615,528 (GRCm39) N486S probably benign Het
Trim59 T C 3: 68,944,206 (GRCm39) N378S probably benign Het
Wdr17 T A 8: 55,104,349 (GRCm39) D908V probably damaging Het
Wdr74 A G 19: 8,716,875 (GRCm39) probably benign Het
Other mutations in Rps6ka5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01072:Rps6ka5 APN 12 100,540,157 (GRCm39) missense probably benign
IGL01450:Rps6ka5 APN 12 100,519,250 (GRCm39) splice site probably benign
IGL01586:Rps6ka5 APN 12 100,537,173 (GRCm39) missense probably damaging 0.99
IGL01743:Rps6ka5 APN 12 100,541,892 (GRCm39) critical splice donor site probably null
IGL02995:Rps6ka5 APN 12 100,540,258 (GRCm39) intron probably benign
IGL03190:Rps6ka5 APN 12 100,524,907 (GRCm39) splice site probably benign
chard UTSW 12 100,582,342 (GRCm39) missense probably damaging 1.00
Ramp UTSW 12 100,541,964 (GRCm39) missense possibly damaging 0.85
zwiebel UTSW 12 100,644,797 (GRCm39) missense probably damaging 0.99
R0055:Rps6ka5 UTSW 12 100,644,839 (GRCm39) missense probably damaging 0.97
R0055:Rps6ka5 UTSW 12 100,644,839 (GRCm39) missense probably damaging 0.97
R0067:Rps6ka5 UTSW 12 100,582,342 (GRCm39) missense probably damaging 1.00
R0212:Rps6ka5 UTSW 12 100,519,428 (GRCm39) splice site probably null
R0761:Rps6ka5 UTSW 12 100,537,141 (GRCm39) missense probably damaging 1.00
R0893:Rps6ka5 UTSW 12 100,540,697 (GRCm39) missense possibly damaging 0.71
R1237:Rps6ka5 UTSW 12 100,541,964 (GRCm39) missense possibly damaging 0.85
R1254:Rps6ka5 UTSW 12 100,585,788 (GRCm39) missense probably damaging 1.00
R1447:Rps6ka5 UTSW 12 100,544,084 (GRCm39) missense probably benign 0.02
R1611:Rps6ka5 UTSW 12 100,537,111 (GRCm39) missense possibly damaging 0.77
R2086:Rps6ka5 UTSW 12 100,585,874 (GRCm39) missense possibly damaging 0.67
R2129:Rps6ka5 UTSW 12 100,644,797 (GRCm39) missense probably damaging 0.99
R2298:Rps6ka5 UTSW 12 100,517,713 (GRCm39) missense probably damaging 0.99
R2432:Rps6ka5 UTSW 12 100,520,664 (GRCm39) missense probably damaging 0.98
R4378:Rps6ka5 UTSW 12 100,564,196 (GRCm39) missense probably damaging 1.00
R4394:Rps6ka5 UTSW 12 100,547,578 (GRCm39) missense probably damaging 0.97
R4461:Rps6ka5 UTSW 12 100,537,123 (GRCm39) missense probably damaging 0.99
R4584:Rps6ka5 UTSW 12 100,547,577 (GRCm39) missense probably damaging 1.00
R4672:Rps6ka5 UTSW 12 100,620,546 (GRCm39) missense possibly damaging 0.93
R4706:Rps6ka5 UTSW 12 100,547,578 (GRCm39) missense probably damaging 0.97
R4706:Rps6ka5 UTSW 12 100,564,144 (GRCm39) splice site probably null
R4707:Rps6ka5 UTSW 12 100,564,144 (GRCm39) splice site probably null
R4966:Rps6ka5 UTSW 12 100,519,325 (GRCm39) missense probably benign 0.01
R5059:Rps6ka5 UTSW 12 100,520,634 (GRCm39) missense probably damaging 0.96
R5404:Rps6ka5 UTSW 12 100,582,352 (GRCm39) missense probably damaging 1.00
R5660:Rps6ka5 UTSW 12 100,585,839 (GRCm39) missense possibly damaging 0.95
R5678:Rps6ka5 UTSW 12 100,691,135 (GRCm39) missense unknown
R5992:Rps6ka5 UTSW 12 100,541,509 (GRCm39) missense possibly damaging 0.68
R6104:Rps6ka5 UTSW 12 100,519,407 (GRCm39) missense possibly damaging 0.84
R6163:Rps6ka5 UTSW 12 100,562,179 (GRCm39) critical splice acceptor site probably null
R6390:Rps6ka5 UTSW 12 100,537,251 (GRCm39) missense probably damaging 0.99
R6599:Rps6ka5 UTSW 12 100,564,168 (GRCm39) missense probably damaging 1.00
R6653:Rps6ka5 UTSW 12 100,517,795 (GRCm39) missense probably damaging 1.00
R6693:Rps6ka5 UTSW 12 100,540,088 (GRCm39) missense probably benign 0.11
R7009:Rps6ka5 UTSW 12 100,585,796 (GRCm39) missense probably damaging 1.00
R7157:Rps6ka5 UTSW 12 100,547,679 (GRCm39) missense probably damaging 1.00
R7196:Rps6ka5 UTSW 12 100,562,123 (GRCm39) missense possibly damaging 0.77
R7510:Rps6ka5 UTSW 12 100,582,327 (GRCm39) missense possibly damaging 0.56
R7565:Rps6ka5 UTSW 12 100,582,342 (GRCm39) missense probably damaging 1.00
R7800:Rps6ka5 UTSW 12 100,524,824 (GRCm39) missense probably damaging 0.97
R7843:Rps6ka5 UTSW 12 100,519,408 (GRCm39) missense possibly damaging 0.92
R8009:Rps6ka5 UTSW 12 100,544,048 (GRCm39) missense probably damaging 0.97
R8057:Rps6ka5 UTSW 12 100,540,055 (GRCm39) critical splice donor site probably null
R8292:Rps6ka5 UTSW 12 100,644,791 (GRCm39) missense possibly damaging 0.83
R8324:Rps6ka5 UTSW 12 100,524,746 (GRCm39) missense possibly damaging 0.92
R8428:Rps6ka5 UTSW 12 100,541,500 (GRCm39) nonsense probably null
R8913:Rps6ka5 UTSW 12 100,520,595 (GRCm39) missense
R9711:Rps6ka5 UTSW 12 100,540,250 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02