Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03058:Vmn2r121'

409312

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r121

Ensembl Gene

ENSMUSG00000072049

Gene Name

vomeronasal 2, receptor 121

Synonyms

EG625699

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.076) question?

Stock #

IGL03058

Quality Score

Status

Chromosome

Chromosomal Location

123037036-123045607 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 123042618 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Asparagine at position 180 (H180N)

Ref Sequence

ENSEMBL: ENSMUSP00000092067 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094491]

AlphaFold

A2BE32

Predicted Effect

probably benign
Transcript: ENSMUST00000094491
AA Change: H180N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000092067
Gene: ENSMUSG00000072049
AA Change: H180N

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	75	448	3.2e-26	PFAM
Pfam:NCD3G	506	560	2.1e-19	PFAM
Pfam:7tm_3	593	828	3.8e-56	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg3	A	G	5: 105,109,112 (GRCm39)	V395A	probably benign	Het
Adck1	A	T	12: 88,425,900 (GRCm39)	T443S	probably benign	Het
Axdnd1	G	A	1: 156,204,233 (GRCm39)	A541V	probably benign	Het
B020011L13Rik	A	G	1: 117,710,699 (GRCm39)	D35G	possibly damaging	Het
Bmp3	T	G	5: 99,019,953 (GRCm39)	I125M	probably damaging	Het
Cdc40	T	C	10: 40,725,824 (GRCm39)	E215G	probably benign	Het
Ces1f	A	G	8: 93,996,600 (GRCm39)		probably null	Het
Chd8	A	C	14: 52,455,730 (GRCm39)	V986G	probably damaging	Het
Clca4a	A	T	3: 144,667,595 (GRCm39)		probably benign	Het
Crhbp	T	A	13: 95,580,306 (GRCm39)	E91V	probably damaging	Het
Dgkh	T	A	14: 78,865,237 (GRCm39)	H53L	probably benign	Het
Dnajc1	T	C	2: 18,222,132 (GRCm39)	D532G	possibly damaging	Het
Dot1l	T	C	10: 80,626,831 (GRCm39)	S230P	probably benign	Het
Evi5	C	T	5: 107,896,017 (GRCm39)	V809M	probably damaging	Het
Fbn1	T	A	2: 125,245,120 (GRCm39)	M256L	probably benign	Het
Fem1al	T	C	11: 29,774,656 (GRCm39)	D267G	probably benign	Het
Fgfr2	C	T	7: 129,784,422 (GRCm39)	D292N	probably damaging	Het
Fmn1	C	T	2: 113,272,159 (GRCm39)		probably benign	Het
Htatsf1	T	A	X: 56,104,281 (GRCm39)	D203E	probably damaging	Het
Kcnh1	T	A	1: 192,117,199 (GRCm39)	L51Q	probably damaging	Het
Lamp5	A	T	2: 135,911,047 (GRCm39)	H260L	probably benign	Het
Mindy4	T	A	6: 55,285,183 (GRCm39)	V659D	probably damaging	Het
Mkks	C	A	2: 136,718,090 (GRCm39)	L397F	probably damaging	Het
Ncan	G	A	8: 70,560,582 (GRCm39)	S795F	possibly damaging	Het
Or13c7d	A	C	4: 43,770,255 (GRCm39)	F252C	probably damaging	Het
Or9g4	T	C	2: 85,505,025 (GRCm39)	I157V	probably benign	Het
Papolg	T	C	11: 23,845,029 (GRCm39)	M4V	probably benign	Het
Pdk3	A	T	X: 92,845,892 (GRCm39)	I143N	probably benign	Het
Polr2a	A	T	11: 69,635,873 (GRCm39)		probably null	Het
Prc1	C	T	7: 79,950,873 (GRCm39)	T78I	probably benign	Het
Ret	C	A	6: 118,152,028 (GRCm39)	D569Y	probably damaging	Het
Samd9l	G	T	6: 3,374,980 (GRCm39)	N760K	probably damaging	Het
Slc5a12	T	A	2: 110,471,137 (GRCm39)	S460T	probably benign	Het
Slco1c1	A	G	6: 141,508,913 (GRCm39)	I573M	probably benign	Het
Spata31f1e	G	A	4: 42,793,764 (GRCm39)	L123F	probably damaging	Het
Steap4	A	G	5: 8,025,664 (GRCm39)	D75G	probably benign	Het
Tcf20	A	G	15: 82,736,205 (GRCm39)	F1749L	probably damaging	Het
Thbs2	T	C	17: 14,910,231 (GRCm39)	T123A	possibly damaging	Het
Tmc3	T	C	7: 83,265,094 (GRCm39)	S663P	possibly damaging	Het
Vnn1	T	C	10: 23,780,442 (GRCm39)	F477L	probably benign	Het
Xpnpep2	A	G	X: 47,214,302 (GRCm39)		probably null	Het
Zfand4	T	C	6: 116,265,038 (GRCm39)	F168L	probably benign	Het

Other mutations in Vmn2r121

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r121	APN	X	123,037,480 (GRCm39)	missense	possibly damaging	0.95
IGL00990:Vmn2r121	APN	X	123,037,499 (GRCm39)	missense	probably benign	0.04
IGL00990:Vmn2r121	APN	X	123,043,413 (GRCm39)	missense	probably benign	0.00
IGL01125:Vmn2r121	APN	X	123,042,504 (GRCm39)	missense	probably damaging	0.99
IGL01450:Vmn2r121	APN	X	123,040,888 (GRCm39)	missense	possibly damaging	0.57
IGL01619:Vmn2r121	APN	X	123,041,997 (GRCm39)	missense	probably benign
IGL01797:Vmn2r121	APN	X	123,041,048 (GRCm39)	splice site	probably benign
IGL02227:Vmn2r121	APN	X	123,042,378 (GRCm39)	missense	probably benign	0.44
IGL02971:Vmn2r121	APN	X	123,037,591 (GRCm39)	missense	probably damaging	1.00
IGL03142:Vmn2r121	APN	X	123,042,635 (GRCm39)	missense	possibly damaging	0.94
IGL03183:Vmn2r121	APN	X	123,042,023 (GRCm39)	missense	probably benign	0.03
E0370:Vmn2r121	UTSW	X	123,037,617 (GRCm39)	missense	probably benign	0.01
R0196:Vmn2r121	UTSW	X	123,041,879 (GRCm39)	missense	probably benign	0.03
R1381:Vmn2r121	UTSW	X	123,037,837 (GRCm39)	missense	probably damaging	1.00
R1399:Vmn2r121	UTSW	X	123,039,545 (GRCm39)	missense	possibly damaging	0.94
R1423:Vmn2r121	UTSW	X	123,039,602 (GRCm39)	missense	possibly damaging	0.52
R1687:Vmn2r121	UTSW	X	123,042,488 (GRCm39)	missense	probably benign	0.39
R2121:Vmn2r121	UTSW	X	123,043,439 (GRCm39)	splice site	probably null
R2124:Vmn2r121	UTSW	X	123,043,439 (GRCm39)	splice site	probably null
R3151:Vmn2r121	UTSW	X	123,040,849 (GRCm39)	missense	probably benign	0.20
R4460:Vmn2r121	UTSW	X	123,038,281 (GRCm39)	missense	probably benign	0.01
R4735:Vmn2r121	UTSW	X	123,038,335 (GRCm39)	missense	probably benign
R5332:Vmn2r121	UTSW	X	123,043,272 (GRCm39)	missense	probably benign
R6102:Vmn2r121	UTSW	X	123,043,272 (GRCm39)	missense	probably benign
X0023:Vmn2r121	UTSW	X	123,045,354 (GRCm39)	missense	possibly damaging	0.64

Posted On

2016-08-02