Incidental Mutation 'IGL03059:Olfr295'
ID409356
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr295
Ensembl Gene ENSMUSG00000059319
Gene Nameolfactory receptor 295
SynonymsMOR220-1, GA_x6K02T2NHDJ-9539243-9538314
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL03059
Quality Score
Status
Chromosome7
Chromosomal Location86583862-86591128 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 86585571 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 99 (I99V)
Ref Sequence ENSEMBL: ENSMUSP00000150377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078447] [ENSMUST00000172965] [ENSMUST00000215365]
Predicted Effect probably benign
Transcript: ENSMUST00000078447
AA Change: I99V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000077542
Gene: ENSMUSG00000059319
AA Change: I99V

DomainStartEndE-ValueType
Pfam:7tm_1 39 288 6.1e-26 PFAM
Pfam:7tm_4 137 281 2.2e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172965
AA Change: I99V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000134371
Gene: ENSMUSG00000057067
AA Change: I99V

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.2e-46 PFAM
Pfam:7tm_1 39 288 2e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215365
AA Change: I99V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahsg T C 16: 22,899,005 V244A possibly damaging Het
Ccdc187 C A 2: 26,294,241 R48M probably null Het
Cnga2 G A X: 72,008,272 R251H probably damaging Het
Cop1 A C 1: 159,306,709 K174Q probably damaging Het
Cul9 T C 17: 46,538,987 D512G probably damaging Het
Flt4 G A 11: 49,642,307 A1140T probably damaging Het
Galnt3 C T 2: 66,093,610 R438H probably damaging Het
Gatm G A 2: 122,609,700 A86V probably damaging Het
Klhl28 C T 12: 64,951,566 A385T probably benign Het
Klhl40 T A 9: 121,778,137 V121E probably damaging Het
L1cam T A X: 73,867,024 H30L probably benign Het
Lss A T 10: 76,532,026 probably benign Het
Mrnip A T 11: 50,199,769 Q253H probably damaging Het
Mroh9 A T 1: 163,024,636 F828Y possibly damaging Het
Mst1 T C 9: 108,084,813 C668R probably damaging Het
Nadk A G 4: 155,586,796 E143G probably benign Het
Nap1l4 C T 7: 143,527,165 probably null Het
Nme8 A G 13: 19,652,244 I254T possibly damaging Het
Olfr1382 A G 11: 49,535,194 Y3C probably benign Het
Olfr374 T A 8: 72,109,998 L144Q probably damaging Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Pkd1l3 C T 8: 109,648,367 L1491F probably damaging Het
Plec G T 15: 76,175,768 T3488N probably damaging Het
Plk2 T G 13: 110,399,134 S497A probably benign Het
Polr1a G A 6: 71,936,512 V617I probably benign Het
Prelid3a C A 18: 67,476,839 Y112* probably null Het
Rnf113a2 C A 12: 84,417,476 S47R possibly damaging Het
Rtel1 A G 2: 181,350,183 N410D probably benign Het
Ryr3 C T 2: 112,800,047 A2140T probably damaging Het
Slc22a29 A G 19: 8,169,990 L336P probably benign Het
Sphkap T A 1: 83,257,242 Q1621L probably damaging Het
Svs1 A T 6: 48,987,415 Y119F probably benign Het
Tcrg-C1 A T 13: 19,215,902 K123* probably null Het
Ttn T A 2: 76,909,519 S3559C probably benign Het
Ubr4 C T 4: 139,480,676 R4923W probably damaging Het
Vac14 T C 8: 110,710,452 L599P probably damaging Het
Wdr5 T C 2: 27,519,734 probably benign Het
Other mutations in Olfr295
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01362:Olfr295 APN 7 86585439 missense possibly damaging 0.91
IGL02248:Olfr295 APN 7 86586104 nonsense probably null
IGL02309:Olfr295 APN 7 86585497 missense possibly damaging 0.84
IGL02866:Olfr295 APN 7 86585693 nonsense probably null
IGL03134:Olfr295 UTSW 7 86586012 missense probably damaging 0.99
R1311:Olfr295 UTSW 7 86585953 missense probably damaging 0.96
R1777:Olfr295 UTSW 7 86586064 missense probably benign
R2259:Olfr295 UTSW 7 86585884 missense possibly damaging 0.80
R2379:Olfr295 UTSW 7 86586192 missense probably benign
R5944:Olfr295 UTSW 7 86585278 start codon destroyed probably null 1.00
R6213:Olfr295 UTSW 7 86585277 start codon destroyed probably null 1.00
R6241:Olfr295 UTSW 7 86586037 missense probably benign 0.35
Posted On2016-08-02