Incidental Mutation 'IGL03059:Olfr374'
ID409366
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr374
Ensembl Gene ENSMUSG00000046881
Gene Nameolfactory receptor 374
SynonymsGA_x6K02T2NUPS-241490-242431, MOR130-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #IGL03059
Quality Score
Status
Chromosome8
Chromosomal Location72107040-72118200 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 72109998 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 144 (L144Q)
Ref Sequence ENSEMBL: ENSMUSP00000147605 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000209675] [ENSMUST00000210435]
Predicted Effect probably damaging
Transcript: ENSMUST00000055735
AA Change: L144Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000054673
Gene: ENSMUSG00000046881
AA Change: L144Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.2e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 224 1.3e-6 PFAM
Pfam:7tm_1 41 290 3e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157835
Predicted Effect probably damaging
Transcript: ENSMUST00000209675
AA Change: L144Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000210435
AA Change: L144Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210923
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahsg T C 16: 22,899,005 V244A possibly damaging Het
Ccdc187 C A 2: 26,294,241 R48M probably null Het
Cnga2 G A X: 72,008,272 R251H probably damaging Het
Cop1 A C 1: 159,306,709 K174Q probably damaging Het
Cul9 T C 17: 46,538,987 D512G probably damaging Het
Flt4 G A 11: 49,642,307 A1140T probably damaging Het
Galnt3 C T 2: 66,093,610 R438H probably damaging Het
Gatm G A 2: 122,609,700 A86V probably damaging Het
Klhl28 C T 12: 64,951,566 A385T probably benign Het
Klhl40 T A 9: 121,778,137 V121E probably damaging Het
L1cam T A X: 73,867,024 H30L probably benign Het
Lss A T 10: 76,532,026 probably benign Het
Mrnip A T 11: 50,199,769 Q253H probably damaging Het
Mroh9 A T 1: 163,024,636 F828Y possibly damaging Het
Mst1 T C 9: 108,084,813 C668R probably damaging Het
Nadk A G 4: 155,586,796 E143G probably benign Het
Nap1l4 C T 7: 143,527,165 probably null Het
Nme8 A G 13: 19,652,244 I254T possibly damaging Het
Olfr1382 A G 11: 49,535,194 Y3C probably benign Het
Olfr295 A G 7: 86,585,571 I99V probably benign Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Pkd1l3 C T 8: 109,648,367 L1491F probably damaging Het
Plec G T 15: 76,175,768 T3488N probably damaging Het
Plk2 T G 13: 110,399,134 S497A probably benign Het
Polr1a G A 6: 71,936,512 V617I probably benign Het
Prelid3a C A 18: 67,476,839 Y112* probably null Het
Rnf113a2 C A 12: 84,417,476 S47R possibly damaging Het
Rtel1 A G 2: 181,350,183 N410D probably benign Het
Ryr3 C T 2: 112,800,047 A2140T probably damaging Het
Slc22a29 A G 19: 8,169,990 L336P probably benign Het
Sphkap T A 1: 83,257,242 Q1621L probably damaging Het
Svs1 A T 6: 48,987,415 Y119F probably benign Het
Tcrg-C1 A T 13: 19,215,902 K123* probably null Het
Ttn T A 2: 76,909,519 S3559C probably benign Het
Ubr4 C T 4: 139,480,676 R4923W probably damaging Het
Vac14 T C 8: 110,710,452 L599P probably damaging Het
Wdr5 T C 2: 27,519,734 probably benign Het
Other mutations in Olfr374
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03022:Olfr374 APN 8 72110124 missense probably damaging 0.99
R1662:Olfr374 UTSW 8 72109779 missense probably benign 0.09
R1977:Olfr374 UTSW 8 72109854 missense probably benign 0.41
R3965:Olfr374 UTSW 8 72110264 missense probably damaging 1.00
R4577:Olfr374 UTSW 8 72110323 nonsense probably null
R4702:Olfr374 UTSW 8 72110200 missense probably damaging 1.00
R4703:Olfr374 UTSW 8 72110200 missense probably damaging 1.00
R4705:Olfr374 UTSW 8 72110200 missense probably damaging 1.00
R4909:Olfr374 UTSW 8 72109581 missense probably damaging 1.00
R6542:Olfr374 UTSW 8 72109871 missense probably damaging 0.98
R6867:Olfr374 UTSW 8 72109863 missense possibly damaging 0.90
R7094:Olfr374 UTSW 8 72109503 intron probably benign
R7148:Olfr374 UTSW 8 72110157 missense possibly damaging 0.50
Posted On2016-08-02