Incidental Mutation 'IGL03060:Igll1'
ID 409423
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Igll1
Ensembl Gene ENSMUSG00000075370
Gene Name immunoglobulin lambda-like polypeptide 1
Synonyms Igll, Lambda 5, Igl-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL03060
Quality Score
Status
Chromosome 16
Chromosomal Location 16678535-16681849 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to T at 16680291 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000097713 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100136] [ENSMUST00000124890]
AlphaFold P20764
Predicted Effect probably null
Transcript: ENSMUST00000100136
SMART Domains Protein: ENSMUSP00000097713
Gene: ENSMUSG00000075370

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
IGc1 126 200 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124649
Predicted Effect probably benign
Transcript: ENSMUST00000124890
SMART Domains Protein: ENSMUSP00000122045
Gene: ENSMUSG00000075370

DomainStartEndE-ValueType
IGc1 102 176 2.17e-31 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000231439
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit spleen hypoplasia, a leaky blockade of B cell development at the pre-B stage, and decreased IgG levels in response to a T-cell dependent antigen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 G A 19: 56,902,682 (GRCm39) Q720* probably null Het
Amph A G 13: 19,278,984 (GRCm39) E153G probably damaging Het
Atad2 T C 15: 57,985,842 (GRCm39) probably benign Het
Atosa A G 9: 74,917,450 (GRCm39) D683G probably damaging Het
Cep152 C T 2: 125,461,907 (GRCm39) probably benign Het
Cntn2 C T 1: 132,456,678 (GRCm39) V123I probably benign Het
Dhrs2 C A 14: 55,474,775 (GRCm39) Q137K probably benign Het
Fam124a A G 14: 62,843,353 (GRCm39) Y287C probably benign Het
Flg2 C T 3: 93,110,920 (GRCm39) R983W unknown Het
Gm9637 G A 14: 19,402,173 (GRCm38) noncoding transcript Het
Helz2 A G 2: 180,871,015 (GRCm39) probably null Het
Iars1 G A 13: 49,843,923 (GRCm39) probably null Het
Iqch A G 9: 63,432,196 (GRCm39) Y361H probably damaging Het
Lrp1b A T 2: 40,527,765 (GRCm39) H105Q probably benign Het
Mapk6 A G 9: 75,305,084 (GRCm39) M111T probably damaging Het
Mrtfa G A 15: 80,929,523 (GRCm39) R27W probably damaging Het
Mt1 T A 8: 94,906,522 (GRCm39) probably benign Het
Myh7b A T 2: 155,474,671 (GRCm39) D1768V probably damaging Het
Myo6 A T 9: 80,168,159 (GRCm39) Q441L probably benign Het
Nt5c3b A T 11: 100,327,045 (GRCm39) Y84N probably damaging Het
Ntmt2 T C 1: 163,544,692 (GRCm39) D97G probably damaging Het
Or1e29 A G 11: 73,667,289 (GRCm39) F288S probably damaging Het
Paxx A G 2: 25,350,196 (GRCm39) L137P probably damaging Het
Ptprz1 T C 6: 22,972,834 (GRCm39) V248A probably damaging Het
Rif1 T A 2: 52,002,149 (GRCm39) C1868S probably damaging Het
Sec23a A T 12: 59,032,891 (GRCm39) C403S probably benign Het
Skint4 G A 4: 111,975,432 (GRCm39) V131I probably benign Het
Sugp2 T C 8: 70,695,837 (GRCm39) V270A possibly damaging Het
Tmed9 A G 13: 55,743,321 (GRCm39) D151G possibly damaging Het
Tubgcp4 A G 2: 121,007,071 (GRCm39) probably benign Het
Uaca A G 9: 60,777,148 (GRCm39) R512G probably damaging Het
Unc80 A G 1: 66,676,169 (GRCm39) Y1999C possibly damaging Het
Vwf T A 6: 125,640,523 (GRCm39) C2320S probably damaging Het
Other mutations in Igll1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00731:Igll1 APN 16 16,678,783 (GRCm39) missense probably benign 0.04
PIT4445001:Igll1 UTSW 16 16,678,783 (GRCm39) missense probably benign 0.04
R0058:Igll1 UTSW 16 16,681,740 (GRCm39) missense probably benign 0.02
R0058:Igll1 UTSW 16 16,681,740 (GRCm39) missense probably benign 0.02
R2014:Igll1 UTSW 16 16,681,639 (GRCm39) missense probably benign
R2015:Igll1 UTSW 16 16,681,639 (GRCm39) missense probably benign
R4242:Igll1 UTSW 16 16,681,564 (GRCm39) missense probably benign 0.15
R5024:Igll1 UTSW 16 16,681,657 (GRCm39) missense probably benign 0.05
R5453:Igll1 UTSW 16 16,681,558 (GRCm39) splice site probably null
R5855:Igll1 UTSW 16 16,678,921 (GRCm39) missense probably damaging 1.00
R6000:Igll1 UTSW 16 16,681,805 (GRCm39) start gained probably benign
R6946:Igll1 UTSW 16 16,678,920 (GRCm39) missense probably damaging 1.00
R7256:Igll1 UTSW 16 16,678,957 (GRCm39) missense probably damaging 1.00
R8904:Igll1 UTSW 16 16,681,576 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02