Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03062:Ficd'

409500

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ficd

Ensembl Gene

ENSMUSG00000053334

Gene Name

FIC domain containing

Synonyms

D5Ertd40e

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03062

Quality Score

Status

Chromosome

Chromosomal Location

113873864-113878661 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 113876314 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 163 (Y163C)

Ref Sequence

ENSEMBL: ENSMUSP00000071719 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000019118] [ENSMUST00000065698] [ENSMUST00000197041]

AlphaFold

Q8BIX9

Predicted Effect

probably benign
Transcript: ENSMUST00000019118

SMART Domains

Protein: ENSMUSP00000019118
Gene: ENSMUSG00000018974

Domain	Start	End	E-Value	Type
low complexity region	2	10	N/A	INTRINSIC
low complexity region	11	33	N/A	INTRINSIC
low complexity region	42	50	N/A	INTRINSIC
low complexity region	65	93	N/A	INTRINSIC
HAT	127	159	1.76e1	SMART
HAT	165	196	4.82e-1	SMART
HAT	202	238	1.53e-3	SMART
low complexity region	269	281	N/A	INTRINSIC
HAT	325	357	1.78e-4	SMART
HAT	360	392	7.83e-1	SMART
HAT	395	431	7.56e0	SMART
HAT	488	521	7.31e-1	SMART
coiled coil region	554	619	N/A	INTRINSIC
low complexity region	626	640	N/A	INTRINSIC
RRM	705	778	1.87e-14	SMART
RRM	802	874	3.2e-22	SMART
Pfam:LSM_int_assoc	877	937	3.1e-28	PFAM
Pfam:Lsm_interact	944	961	2e-9	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000065698
AA Change: Y163C

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071719
Gene: ENSMUSG00000053334
AA Change: Y163C

Domain	Start	End	E-Value	Type
transmembrane domain	20	42	N/A	INTRINSIC
SCOP:d1elwa_	105	180	2e-8	SMART
Pfam:Fic	284	381	1.8e-29	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000197041

SMART Domains

Protein: ENSMUSP00000143778
Gene: ENSMUSG00000018974

Domain	Start	End	E-Value	Type
low complexity region	2	10	N/A	INTRINSIC
low complexity region	11	33	N/A	INTRINSIC
low complexity region	42	50	N/A	INTRINSIC
low complexity region	65	93	N/A	INTRINSIC
HAT	127	159	1.76e1	SMART
HAT	165	196	4.82e-1	SMART
HAT	202	238	1.53e-3	SMART
low complexity region	269	281	N/A	INTRINSIC
Blast:HAT	292	323	1e-5	BLAST
HAT	325	357	1.33e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb10	C	T	8: 124,681,054 (GRCm39)	R714Q	possibly damaging	Het
Abcb5	T	A	12: 118,899,822 (GRCm39)	I282L	probably benign	Het
Aox1	A	T	1: 58,117,624 (GRCm39)	E835D	probably benign	Het
Arhgap17	C	T	7: 122,921,097 (GRCm39)		probably null	Het
Bltp1	T	C	3: 37,092,666 (GRCm39)		probably benign	Het
Calcr	C	T	6: 3,693,718 (GRCm39)	V359I	probably benign	Het
Chd9	T	A	8: 91,741,895 (GRCm39)		probably benign	Het
Col28a1	T	C	6: 8,017,029 (GRCm39)		probably benign	Het
Dnajc11	A	G	4: 152,055,318 (GRCm39)	E171G	possibly damaging	Het
Efhd1	T	C	1: 87,192,406 (GRCm39)	F79L	possibly damaging	Het
Fam83a	A	T	15: 57,856,473 (GRCm39)		probably null	Het
Fam98a	A	G	17: 75,847,100 (GRCm39)		probably benign	Het
Filip1l	T	C	16: 57,327,167 (GRCm39)	S66P	probably damaging	Het
Fmo5	A	G	3: 97,542,909 (GRCm39)	Y73C	probably damaging	Het
Galnt12	C	A	4: 47,122,566 (GRCm39)	R574S	possibly damaging	Het
Klc3	C	A	7: 19,128,987 (GRCm39)	G461W	probably damaging	Het
Lmo7	A	T	14: 102,149,515 (GRCm39)	T973S	possibly damaging	Het
Loxl1	C	A	9: 58,219,193 (GRCm39)	G326V	possibly damaging	Het
Lrrc24	A	G	15: 76,602,504 (GRCm39)	V127A	probably benign	Het
Lyrm1	T	C	7: 119,515,354 (GRCm39)		probably benign	Het
Med28	G	A	5: 45,679,811 (GRCm39)	V65I	probably damaging	Het
Mgat4c	T	C	10: 102,224,322 (GRCm39)	Y179H	probably damaging	Het
Micall1	A	C	15: 78,998,881 (GRCm39)	N58T	probably damaging	Het
Mtcl3	T	A	10: 29,074,945 (GRCm39)	F911Y	probably damaging	Het
Ncoa4	T	A	14: 31,895,377 (GRCm39)	M72K	possibly damaging	Het
Nutm1	T	C	2: 112,079,278 (GRCm39)	Q879R	probably benign	Het
Or4d6	C	T	19: 12,086,512 (GRCm39)	V133I	probably benign	Het
Or8b12i	T	A	9: 20,082,463 (GRCm39)	I135F	probably damaging	Het
Or8g52	T	A	9: 39,631,331 (GRCm39)	D269E	probably benign	Het
Phf11b	T	C	14: 59,562,373 (GRCm39)	I177M	probably damaging	Het
Pin1rt1	T	G	2: 104,545,052 (GRCm39)	I27L	probably benign	Het
Plxna2	T	C	1: 194,444,858 (GRCm39)	V750A	possibly damaging	Het
Pou5f1	A	T	17: 35,820,936 (GRCm39)	N126I	possibly damaging	Het
Ptprn	A	T	1: 75,224,517 (GRCm39)	H946Q	possibly damaging	Het
Rnf43	G	T	11: 87,623,130 (GRCm39)	G744*	probably null	Het
Rsbn1	C	A	3: 103,860,945 (GRCm39)		probably benign	Het
Sars2	T	A	7: 28,446,206 (GRCm39)	I145N	possibly damaging	Het
Sh3tc2	A	T	18: 62,144,951 (GRCm39)	E1135V	probably damaging	Het
Shroom1	A	G	11: 53,354,206 (GRCm39)	D42G	probably benign	Het
Sidt2	A	G	9: 45,853,981 (GRCm39)		probably null	Het
Slc39a8	T	C	3: 135,592,558 (GRCm39)		probably benign	Het
Slc9c1	T	C	16: 45,420,121 (GRCm39)	S1059P	probably benign	Het
Socs6	A	T	18: 88,887,970 (GRCm39)	M315K	probably benign	Het
Speer2	T	C	16: 69,654,865 (GRCm39)	E200G	probably damaging	Het
Sult2a5	T	A	7: 13,358,107 (GRCm39)		probably null	Het
Tmbim1	A	T	1: 74,330,858 (GRCm39)	I168N	possibly damaging	Het
Trim38	T	C	13: 23,966,946 (GRCm39)	V131A	probably damaging	Het
Ube2o	A	G	11: 116,432,468 (GRCm39)	S833P	probably damaging	Het
Uggt2	T	C	14: 119,312,758 (GRCm39)	I350M	probably damaging	Het
Unc80	A	G	1: 66,548,648 (GRCm39)	D640G	probably damaging	Het
Vmn2r13	A	G	5: 109,304,148 (GRCm39)	F761S	probably damaging	Het
Vmn2r54	C	T	7: 12,366,355 (GRCm39)	C193Y	probably damaging	Het

Other mutations in Ficd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01622:Ficd	APN	5	113,876,622 (GRCm39)	missense	probably damaging	1.00
IGL01774:Ficd	APN	5	113,877,073 (GRCm39)	missense	probably damaging	0.98
IGL01899:Ficd	APN	5	113,875,158 (GRCm39)	missense	probably benign
IGL02237:Ficd	APN	5	113,876,373 (GRCm39)	missense	probably damaging	0.98
IGL02527:Ficd	APN	5	113,875,027 (GRCm39)	missense	probably benign	0.04
IGL03030:Ficd	APN	5	113,874,990 (GRCm39)	missense	probably benign
IGL03339:Ficd	APN	5	113,876,800 (GRCm39)	missense	probably benign	0.00
R0145:Ficd	UTSW	5	113,876,880 (GRCm39)	missense	probably damaging	1.00
R5207:Ficd	UTSW	5	113,875,072 (GRCm39)	missense	probably benign	0.15
R5530:Ficd	UTSW	5	113,876,986 (GRCm39)	missense	probably damaging	1.00
R6730:Ficd	UTSW	5	113,876,773 (GRCm39)	missense	probably damaging	1.00
R7256:Ficd	UTSW	5	113,876,880 (GRCm39)	missense	probably damaging	1.00
R7624:Ficd	UTSW	5	113,876,751 (GRCm39)	missense	probably benign	0.03
R7960:Ficd	UTSW	5	113,877,020 (GRCm39)	missense	probably benign	0.00
R8757:Ficd	UTSW	5	113,876,575 (GRCm39)	missense	probably damaging	0.99
R8759:Ficd	UTSW	5	113,876,575 (GRCm39)	missense	probably damaging	0.99
R8870:Ficd	UTSW	5	113,876,248 (GRCm39)	missense	probably damaging	0.98
R9224:Ficd	UTSW	5	113,875,196 (GRCm39)	missense	probably benign

Posted On

2016-08-02