Incidental Mutation 'IGL03062:Trim38'
ID 409516
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trim38
Ensembl Gene ENSMUSG00000064140
Gene Name tripartite motif-containing 38
Synonyms LOC214158
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL03062
Quality Score
Status
Chromosome 13
Chromosomal Location 23962483-23975721 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 23966946 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 131 (V131A)
Ref Sequence ENSEMBL: ENSMUSP00000153240 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074067] [ENSMUST00000223911] [ENSMUST00000226039]
AlphaFold Q5SZ99
Predicted Effect probably damaging
Transcript: ENSMUST00000074067
AA Change: V131A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000073709
Gene: ENSMUSG00000064140
AA Change: V131A

DomainStartEndE-ValueType
RING 16 61 8.95e-7 SMART
BBOX 90 131 4.34e-5 SMART
coiled coil region 202 249 N/A INTRINSIC
PRY 293 347 2.31e-9 SMART
SPRY 348 469 6.71e-21 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000223911
AA Change: V131A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000226039
AA Change: V131A

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased poly(I:C) and LPS-induced IFN-beta, TNFalpha and IL6 with increased induced mortality induced by poly(I:C), LPS or S. typhimurium infection, [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb10 C T 8: 124,681,054 (GRCm39) R714Q possibly damaging Het
Abcb5 T A 12: 118,899,822 (GRCm39) I282L probably benign Het
Aox1 A T 1: 58,117,624 (GRCm39) E835D probably benign Het
Arhgap17 C T 7: 122,921,097 (GRCm39) probably null Het
Bltp1 T C 3: 37,092,666 (GRCm39) probably benign Het
Calcr C T 6: 3,693,718 (GRCm39) V359I probably benign Het
Chd9 T A 8: 91,741,895 (GRCm39) probably benign Het
Col28a1 T C 6: 8,017,029 (GRCm39) probably benign Het
Dnajc11 A G 4: 152,055,318 (GRCm39) E171G possibly damaging Het
Efhd1 T C 1: 87,192,406 (GRCm39) F79L possibly damaging Het
Fam83a A T 15: 57,856,473 (GRCm39) probably null Het
Fam98a A G 17: 75,847,100 (GRCm39) probably benign Het
Ficd A G 5: 113,876,314 (GRCm39) Y163C probably damaging Het
Filip1l T C 16: 57,327,167 (GRCm39) S66P probably damaging Het
Fmo5 A G 3: 97,542,909 (GRCm39) Y73C probably damaging Het
Galnt12 C A 4: 47,122,566 (GRCm39) R574S possibly damaging Het
Klc3 C A 7: 19,128,987 (GRCm39) G461W probably damaging Het
Lmo7 A T 14: 102,149,515 (GRCm39) T973S possibly damaging Het
Loxl1 C A 9: 58,219,193 (GRCm39) G326V possibly damaging Het
Lrrc24 A G 15: 76,602,504 (GRCm39) V127A probably benign Het
Lyrm1 T C 7: 119,515,354 (GRCm39) probably benign Het
Med28 G A 5: 45,679,811 (GRCm39) V65I probably damaging Het
Mgat4c T C 10: 102,224,322 (GRCm39) Y179H probably damaging Het
Micall1 A C 15: 78,998,881 (GRCm39) N58T probably damaging Het
Mtcl3 T A 10: 29,074,945 (GRCm39) F911Y probably damaging Het
Ncoa4 T A 14: 31,895,377 (GRCm39) M72K possibly damaging Het
Nutm1 T C 2: 112,079,278 (GRCm39) Q879R probably benign Het
Or4d6 C T 19: 12,086,512 (GRCm39) V133I probably benign Het
Or8b12i T A 9: 20,082,463 (GRCm39) I135F probably damaging Het
Or8g52 T A 9: 39,631,331 (GRCm39) D269E probably benign Het
Phf11b T C 14: 59,562,373 (GRCm39) I177M probably damaging Het
Pin1rt1 T G 2: 104,545,052 (GRCm39) I27L probably benign Het
Plxna2 T C 1: 194,444,858 (GRCm39) V750A possibly damaging Het
Pou5f1 A T 17: 35,820,936 (GRCm39) N126I possibly damaging Het
Ptprn A T 1: 75,224,517 (GRCm39) H946Q possibly damaging Het
Rnf43 G T 11: 87,623,130 (GRCm39) G744* probably null Het
Rsbn1 C A 3: 103,860,945 (GRCm39) probably benign Het
Sars2 T A 7: 28,446,206 (GRCm39) I145N possibly damaging Het
Sh3tc2 A T 18: 62,144,951 (GRCm39) E1135V probably damaging Het
Shroom1 A G 11: 53,354,206 (GRCm39) D42G probably benign Het
Sidt2 A G 9: 45,853,981 (GRCm39) probably null Het
Slc39a8 T C 3: 135,592,558 (GRCm39) probably benign Het
Slc9c1 T C 16: 45,420,121 (GRCm39) S1059P probably benign Het
Socs6 A T 18: 88,887,970 (GRCm39) M315K probably benign Het
Speer2 T C 16: 69,654,865 (GRCm39) E200G probably damaging Het
Sult2a5 T A 7: 13,358,107 (GRCm39) probably null Het
Tmbim1 A T 1: 74,330,858 (GRCm39) I168N possibly damaging Het
Ube2o A G 11: 116,432,468 (GRCm39) S833P probably damaging Het
Uggt2 T C 14: 119,312,758 (GRCm39) I350M probably damaging Het
Unc80 A G 1: 66,548,648 (GRCm39) D640G probably damaging Het
Vmn2r13 A G 5: 109,304,148 (GRCm39) F761S probably damaging Het
Vmn2r54 C T 7: 12,366,355 (GRCm39) C193Y probably damaging Het
Other mutations in Trim38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00915:Trim38 APN 13 23,975,015 (GRCm39) missense possibly damaging 0.91
IGL01592:Trim38 APN 13 23,975,410 (GRCm39) missense possibly damaging 0.85
IGL02339:Trim38 APN 13 23,972,213 (GRCm39) missense probably damaging 1.00
IGL03278:Trim38 APN 13 23,974,979 (GRCm39) missense possibly damaging 0.65
R0630:Trim38 UTSW 13 23,975,115 (GRCm39) nonsense probably null
R1263:Trim38 UTSW 13 23,975,117 (GRCm39) missense probably damaging 1.00
R1560:Trim38 UTSW 13 23,966,685 (GRCm39) missense probably benign 0.02
R1978:Trim38 UTSW 13 23,975,081 (GRCm39) missense probably damaging 1.00
R4407:Trim38 UTSW 13 23,975,474 (GRCm39) missense probably benign 0.04
R4462:Trim38 UTSW 13 23,975,435 (GRCm39) missense probably null 1.00
R4649:Trim38 UTSW 13 23,966,952 (GRCm39) missense probably damaging 1.00
R4651:Trim38 UTSW 13 23,966,952 (GRCm39) missense probably damaging 1.00
R4653:Trim38 UTSW 13 23,966,952 (GRCm39) missense probably damaging 1.00
R4816:Trim38 UTSW 13 23,972,264 (GRCm39) missense probably damaging 1.00
R4970:Trim38 UTSW 13 23,975,312 (GRCm39) missense probably damaging 0.98
R5946:Trim38 UTSW 13 23,966,717 (GRCm39) missense probably benign 0.04
R6538:Trim38 UTSW 13 23,969,932 (GRCm39) missense probably damaging 0.97
R6974:Trim38 UTSW 13 23,973,502 (GRCm39) missense probably benign 0.05
R7227:Trim38 UTSW 13 23,969,946 (GRCm39) missense possibly damaging 0.88
R7319:Trim38 UTSW 13 23,975,384 (GRCm39) missense probably damaging 1.00
R7425:Trim38 UTSW 13 23,972,365 (GRCm39) missense probably benign 0.02
R8243:Trim38 UTSW 13 23,975,378 (GRCm39) missense probably damaging 1.00
R8965:Trim38 UTSW 13 23,975,006 (GRCm39) missense possibly damaging 0.65
R9354:Trim38 UTSW 13 23,969,875 (GRCm39) missense probably benign 0.09
R9573:Trim38 UTSW 13 23,966,688 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02