Incidental Mutation 'IGL03065:Pla2g15'
ID 409640
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pla2g15
Ensembl Gene ENSMUSG00000031903
Gene Name phospholipase A2, group XV
Synonyms Lpla2, C87498, Lypla3, LLPL
Accession Numbers
Essential gene? Probably non essential (E-score: 0.197) question?
Stock # IGL03065
Quality Score
Status
Chromosome 8
Chromosomal Location 106877031-106891347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 106886851 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 114 (R114H)
Ref Sequence ENSEMBL: ENSMUSP00000148565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034377] [ENSMUST00000212963]
AlphaFold Q8VEB4
Predicted Effect probably benign
Transcript: ENSMUST00000034377
AA Change: R114H

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000034377
Gene: ENSMUSG00000031903
AA Change: R114H

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:LCAT 72 399 6.2e-84 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212116
Predicted Effect probably benign
Transcript: ENSMUST00000212963
AA Change: R114H

PolyPhen 2 Score 0.204 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutant mice do not develop atherosclerotic lesions even when fed an atherogenic diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl1 A G 8: 84,665,143 (GRCm39) M1322V possibly damaging Het
Adprh C T 16: 38,266,396 (GRCm39) V249I probably benign Het
Afg2a T C 3: 37,486,328 (GRCm39) V350A possibly damaging Het
Als2 T C 1: 59,255,031 (GRCm39) S109G probably benign Het
Bpifa1 T A 2: 153,989,562 (GRCm39) N250K probably damaging Het
Capn9 A C 8: 125,332,298 (GRCm39) Y423S probably damaging Het
Cd200r1 T G 16: 44,614,645 (GRCm39) V308G probably benign Het
Cic T C 7: 24,985,246 (GRCm39) probably benign Het
Col5a1 T A 2: 27,922,757 (GRCm39) I275N possibly damaging Het
Col6a4 C A 9: 105,918,363 (GRCm39) probably benign Het
Cpeb1 T C 7: 81,086,038 (GRCm39) R35G probably benign Het
Cul1 A G 6: 47,472,015 (GRCm39) Y52C probably damaging Het
Dctn1 T C 6: 83,169,475 (GRCm39) F496L probably damaging Het
Dock11 G T X: 35,310,699 (GRCm39) probably benign Het
Eaf2 C T 16: 36,648,484 (GRCm39) R12H probably benign Het
Gcc1 T A 6: 28,418,401 (GRCm39) Q644L possibly damaging Het
Gm44865 C T 7: 108,165,004 (GRCm39) probably benign Het
Golgb1 C T 16: 36,733,228 (GRCm39) S825L probably benign Het
Gstp3 C T 19: 4,108,730 (GRCm39) probably null Het
Heph T A X: 95,571,173 (GRCm39) I669N probably benign Het
Il12rb1 A T 8: 71,273,202 (GRCm39) Y635F possibly damaging Het
Ing3 G A 6: 21,971,221 (GRCm39) A331T probably benign Het
Ipo8 T A 6: 148,686,205 (GRCm39) I762F probably benign Het
Itpr3 G A 17: 27,310,907 (GRCm39) R510Q probably damaging Het
Kif16b A G 2: 142,461,833 (GRCm39) Y1273H probably damaging Het
Map3k14 T C 11: 103,115,927 (GRCm39) E784G probably damaging Het
Mpdz A T 4: 81,210,802 (GRCm39) N1694K probably damaging Het
Myh13 T C 11: 67,235,679 (GRCm39) F648S probably damaging Het
Myh4 A G 11: 67,149,982 (GRCm39) H1847R probably benign Het
Ncoa7 T A 10: 30,523,993 (GRCm39) D840V probably damaging Het
Nxpe2 T A 9: 48,230,992 (GRCm39) N459I possibly damaging Het
Or4d10c C A 19: 12,065,975 (GRCm39) L60F possibly damaging Het
Or4k2 C A 14: 50,424,465 (GRCm39) D70Y probably damaging Het
Or4k47 T C 2: 111,451,535 (GRCm39) K295E probably damaging Het
Ovgp1 T C 3: 105,893,682 (GRCm39) F485S probably benign Het
Parp4 G T 14: 56,875,326 (GRCm39) A1182S probably benign Het
Pkd1l2 G A 8: 117,792,484 (GRCm39) T436I probably benign Het
Plppr3 T A 10: 79,701,880 (GRCm39) T321S probably benign Het
Rnf113a1 A G X: 36,455,748 (GRCm39) D235G probably benign Het
Rsrp1 A G 4: 134,651,700 (GRCm39) T155A possibly damaging Het
Simc1 G T 13: 54,685,025 (GRCm39) C87F probably damaging Het
Slco1a5 A G 6: 142,194,569 (GRCm39) probably benign Het
Slco1a8 C A 6: 141,938,228 (GRCm39) L230F probably damaging Het
Smyd5 A G 6: 85,419,146 (GRCm39) D276G possibly damaging Het
Tmem132c A G 5: 127,640,688 (GRCm39) Y953C probably damaging Het
Trank1 T A 9: 111,219,361 (GRCm39) S2033T possibly damaging Het
Trim69 A G 2: 122,009,115 (GRCm39) T392A probably damaging Het
Tsks T C 7: 44,592,724 (GRCm39) V6A probably damaging Het
Yjefn3 A G 8: 70,342,206 (GRCm39) probably benign Het
Zfp263 T G 16: 3,564,344 (GRCm39) D211E probably benign Het
Zfp994 A T 17: 22,421,661 (GRCm39) F51L probably damaging Het
Znfx1 A T 2: 166,897,685 (GRCm39) M413K probably benign Het
Other mutations in Pla2g15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01522:Pla2g15 APN 8 106,889,748 (GRCm39) missense probably benign 0.00
IGL02719:Pla2g15 APN 8 106,886,828 (GRCm39) missense probably benign 0.01
R0125:Pla2g15 UTSW 8 106,889,756 (GRCm39) missense probably benign 0.00
R1691:Pla2g15 UTSW 8 106,881,581 (GRCm39) missense possibly damaging 0.93
R1939:Pla2g15 UTSW 8 106,889,927 (GRCm39) missense probably damaging 0.96
R3887:Pla2g15 UTSW 8 106,887,767 (GRCm39) missense probably damaging 0.99
R4633:Pla2g15 UTSW 8 106,886,887 (GRCm39) missense probably damaging 1.00
R4702:Pla2g15 UTSW 8 106,889,691 (GRCm39) missense probably benign 0.08
R4703:Pla2g15 UTSW 8 106,889,691 (GRCm39) missense probably benign 0.08
R4705:Pla2g15 UTSW 8 106,889,691 (GRCm39) missense probably benign 0.08
R4766:Pla2g15 UTSW 8 106,889,703 (GRCm39) missense probably damaging 1.00
R4928:Pla2g15 UTSW 8 106,889,850 (GRCm39) nonsense probably null
R5543:Pla2g15 UTSW 8 106,887,775 (GRCm39) missense probably damaging 0.99
R6489:Pla2g15 UTSW 8 106,889,826 (GRCm39) missense probably benign 0.10
R6802:Pla2g15 UTSW 8 106,877,213 (GRCm39) missense probably damaging 0.99
R7381:Pla2g15 UTSW 8 106,889,576 (GRCm39) missense probably benign 0.03
R9245:Pla2g15 UTSW 8 106,889,539 (GRCm39) missense possibly damaging 0.81
R9302:Pla2g15 UTSW 8 106,877,201 (GRCm39) missense probably benign 0.04
R9623:Pla2g15 UTSW 8 106,887,275 (GRCm39) missense possibly damaging 0.90
Z1177:Pla2g15 UTSW 8 106,889,619 (GRCm39) missense probably benign 0.19
Posted On 2016-08-02