Incidental Mutation 'IGL03066:Vmn2r6'
ID409679
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r6
Ensembl Gene ENSMUSG00000090581
Gene Namevomeronasal 2, receptor 6
SynonymsEG620718, EG667069
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.572) question?
Stock #IGL03066
Quality Score
Status
Chromosome3
Chromosomal Location64537561-64565298 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 64565153 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 49 (N49I)
Ref Sequence ENSEMBL: ENSMUSP00000135148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000176481]
Predicted Effect probably damaging
Transcript: ENSMUST00000176481
AA Change: N49I

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: N49I

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 88 505 9.8e-77 PFAM
Pfam:Peripla_BP_6 142 331 3.4e-10 PFAM
Pfam:NCD3G 547 600 5.4e-17 PFAM
Pfam:7tm_3 633 867 3.9e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Brd4 A C 17: 32,199,088 probably benign Het
Cd209d C A 8: 3,878,437 probably null Het
Cela2a T A 4: 141,821,454 I124F probably damaging Het
Cnot2 A T 10: 116,499,357 N245K probably benign Het
Cpt2 A G 4: 107,907,986 F148L probably benign Het
Ctsj A C 13: 61,004,488 H21Q possibly damaging Het
Cul4a A G 8: 13,133,776 N388S probably benign Het
Dnah12 A G 14: 26,697,398 D147G probably benign Het
Dnhd1 A G 7: 105,719,882 T4287A probably damaging Het
Dock10 C A 1: 80,585,041 C534F probably benign Het
Efcab14 A G 4: 115,738,804 E49G probably benign Het
Fancm G T 12: 65,125,114 E86* probably null Het
Galnt17 A T 5: 130,900,648 S440R probably benign Het
Hectd4 T A 5: 121,365,053 Y4362N possibly damaging Het
Lctl T G 9: 64,117,735 M1R probably null Het
Llgl1 A G 11: 60,706,034 T154A possibly damaging Het
Mink1 G T 11: 70,608,889 V750F probably benign Het
Mroh7 A G 4: 106,692,398 V950A possibly damaging Het
Myg1 G A 15: 102,334,366 probably benign Het
Olfr1265 A T 2: 90,037,434 I172F probably damaging Het
Olfr1415 T A 1: 92,491,583 R57S probably damaging Het
Olfr77 A G 9: 19,920,371 H54R probably benign Het
Pask A T 1: 93,330,866 S253R probably benign Het
Pkd1 C A 17: 24,586,234 H3253Q probably damaging Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Rapgef4 A G 2: 72,141,179 probably benign Het
Rnf169 G T 7: 99,925,553 R612S possibly damaging Het
Sclt1 A T 3: 41,717,843 D104E probably benign Het
Shh G T 5: 28,461,371 D172E probably damaging Het
Sil1 G T 18: 35,269,206 probably benign Het
Slc19a3 A G 1: 83,014,836 I388T probably damaging Het
Spink5 A G 18: 44,016,390 Y946C probably damaging Het
Sulf1 A T 1: 12,807,944 I219F probably damaging Het
Tcf3 T C 10: 80,413,045 D529G probably damaging Het
Tmem2 G A 19: 21,823,843 D775N possibly damaging Het
Txnip G A 3: 96,559,618 E203K probably damaging Het
Ubc G T 5: 125,388,263 probably benign Het
Ubxn4 A T 1: 128,260,854 probably null Het
Usp16 T C 16: 87,471,833 V284A probably damaging Het
Ythdf1 A T 2: 180,911,546 I292N probably damaging Het
Zfp128 A G 7: 12,890,117 I137M probably benign Het
Other mutations in Vmn2r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01547:Vmn2r6 APN 3 64538104 missense probably damaging 1.00
IGL01968:Vmn2r6 APN 3 64556345 missense possibly damaging 0.94
IGL02009:Vmn2r6 APN 3 64537902 missense possibly damaging 0.61
IGL02039:Vmn2r6 APN 3 64556189 missense probably damaging 1.00
IGL02652:Vmn2r6 APN 3 64556328 missense probably benign 0.24
IGL02737:Vmn2r6 APN 3 64556490 missense possibly damaging 0.55
IGL02808:Vmn2r6 APN 3 64556496 missense probably damaging 1.00
IGL03331:Vmn2r6 APN 3 64538007 missense probably damaging 1.00
R0010:Vmn2r6 UTSW 3 64559545 nonsense probably null
R0206:Vmn2r6 UTSW 3 64539912 missense probably benign
R0206:Vmn2r6 UTSW 3 64539912 missense probably benign
R0208:Vmn2r6 UTSW 3 64539912 missense probably benign
R0427:Vmn2r6 UTSW 3 64559587 missense probably damaging 1.00
R0466:Vmn2r6 UTSW 3 64556302 missense probably damaging 1.00
R1018:Vmn2r6 UTSW 3 64556840 missense probably benign 0.00
R1104:Vmn2r6 UTSW 3 64538066 missense possibly damaging 0.93
R1186:Vmn2r6 UTSW 3 64565067 missense probably benign 0.01
R1245:Vmn2r6 UTSW 3 64556790 missense possibly damaging 0.53
R1295:Vmn2r6 UTSW 3 64538273 missense probably damaging 1.00
R1473:Vmn2r6 UTSW 3 64538158 nonsense probably null
R1498:Vmn2r6 UTSW 3 64556469 missense probably damaging 1.00
R1925:Vmn2r6 UTSW 3 64556277 missense possibly damaging 0.87
R2044:Vmn2r6 UTSW 3 64537841 missense probably damaging 0.96
R2069:Vmn2r6 UTSW 3 64556098 missense possibly damaging 0.89
R2253:Vmn2r6 UTSW 3 64559718 missense probably damaging 1.00
R2261:Vmn2r6 UTSW 3 64556669 missense probably benign 0.24
R2262:Vmn2r6 UTSW 3 64556669 missense probably benign 0.24
R2350:Vmn2r6 UTSW 3 64556352 missense probably benign 0.01
R2680:Vmn2r6 UTSW 3 64538286 missense possibly damaging 0.91
R2846:Vmn2r6 UTSW 3 64556790 missense possibly damaging 0.53
R2860:Vmn2r6 UTSW 3 64547339 missense probably benign 0.00
R2861:Vmn2r6 UTSW 3 64547339 missense probably benign 0.00
R3766:Vmn2r6 UTSW 3 64556508 missense probably benign 0.19
R3870:Vmn2r6 UTSW 3 64556621 missense probably damaging 0.96
R4018:Vmn2r6 UTSW 3 64556472 missense probably benign 0.05
R4024:Vmn2r6 UTSW 3 64538250 missense possibly damaging 0.73
R4026:Vmn2r6 UTSW 3 64538250 missense possibly damaging 0.73
R4227:Vmn2r6 UTSW 3 64537948 missense probably damaging 0.99
R4526:Vmn2r6 UTSW 3 64537724 missense probably benign 0.32
R4570:Vmn2r6 UTSW 3 64559647 missense probably benign 0.31
R4894:Vmn2r6 UTSW 3 64547408 missense probably benign
R4934:Vmn2r6 UTSW 3 64556345 missense probably damaging 0.99
R5057:Vmn2r6 UTSW 3 64537786 missense probably damaging 1.00
R5059:Vmn2r6 UTSW 3 64537623 missense possibly damaging 0.89
R5148:Vmn2r6 UTSW 3 64556594 missense probably damaging 0.99
R5155:Vmn2r6 UTSW 3 64538514 missense probably benign 0.44
R5179:Vmn2r6 UTSW 3 64537990 missense probably benign 0.00
R5256:Vmn2r6 UTSW 3 64556842 missense probably benign 0.33
R5861:Vmn2r6 UTSW 3 64556033 missense probably benign 0.00
R5950:Vmn2r6 UTSW 3 64565231 missense probably benign 0.05
R6081:Vmn2r6 UTSW 3 64556532 missense probably benign 0.25
R6173:Vmn2r6 UTSW 3 64559755 missense probably damaging 1.00
R6190:Vmn2r6 UTSW 3 64538003 missense probably benign 0.04
R6240:Vmn2r6 UTSW 3 64556805 missense probably damaging 1.00
R6433:Vmn2r6 UTSW 3 64547380 nonsense probably null
R6645:Vmn2r6 UTSW 3 64556876 missense probably damaging 1.00
R6791:Vmn2r6 UTSW 3 64538159 missense probably damaging 1.00
X0020:Vmn2r6 UTSW 3 64538450 missense probably benign
X0066:Vmn2r6 UTSW 3 64547378 missense probably damaging 1.00
Posted On2016-08-02