Incidental Mutation 'IGL03067:Foxk2'
ID 409746
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Foxk2
Ensembl Gene ENSMUSG00000039275
Gene Name forkhead box K2
Synonyms 1110054H05Rik, Ilf1, 5730434B08Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03067
Quality Score
Status
Chromosome 11
Chromosomal Location 121150816-121200722 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 121176394 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 180 (T180M)
Ref Sequence ENSEMBL: ENSMUSP00000101719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106113]
AlphaFold Q3UCQ1
Predicted Effect possibly damaging
Transcript: ENSMUST00000106113
AA Change: T180M

PolyPhen 2 Score 0.871 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000101719
Gene: ENSMUSG00000039275
AA Change: T180M

DomainStartEndE-ValueType
low complexity region 2 32 N/A INTRINSIC
FHA 47 119 9.96e-10 SMART
FH 247 338 2.2e-52 SMART
low complexity region 440 465 N/A INTRINSIC
low complexity region 486 498 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A T 11: 119,900,909 (GRCm39) D1162E probably benign Het
Abhd2 T C 7: 79,009,782 (GRCm39) F386L probably benign Het
Adamts6 C T 13: 104,433,783 (GRCm39) R71W probably damaging Het
Adgrv1 T C 13: 81,590,599 (GRCm39) Y4403C probably damaging Het
Aldoart1 A T 4: 72,770,194 (GRCm39) C205S possibly damaging Het
Ap2a1 C A 7: 44,552,935 (GRCm39) A711S probably benign Het
Arhgef28 A G 13: 98,124,794 (GRCm39) I496T probably benign Het
Cyp27a1 A G 1: 74,771,068 (GRCm39) probably null Het
Cyp2c69 C T 19: 39,869,537 (GRCm39) G161S probably benign Het
Dpy19l1 A G 9: 24,349,956 (GRCm39) V428A probably benign Het
Gm3402 C A 5: 146,451,399 (GRCm39) H86N possibly damaging Het
Gm3543 A G 14: 41,802,830 (GRCm39) probably benign Het
Gnai3 T C 3: 108,025,609 (GRCm39) probably benign Het
Hmcn2 C T 2: 31,236,642 (GRCm39) P395L probably damaging Het
Igsf10 T C 3: 59,226,339 (GRCm39) I2445V probably benign Het
Il10ra T C 9: 45,167,157 (GRCm39) T465A probably benign Het
Itpr2 G A 6: 146,226,680 (GRCm39) L1322F probably damaging Het
Man1b1 T C 2: 25,239,344 (GRCm39) Y536H probably benign Het
P3h1 A G 4: 119,092,477 (GRCm39) H170R probably damaging Het
Pakap A T 4: 57,648,038 (GRCm39) T59S probably benign Het
Parp14 A G 16: 35,676,878 (GRCm39) V1030A probably benign Het
Pdzd2 A G 15: 12,388,628 (GRCm39) probably null Het
Pilra T C 5: 137,821,843 (GRCm39) Y264C probably damaging Het
Ptprf A G 4: 118,067,910 (GRCm39) V1799A possibly damaging Het
Rap1gap2 A G 11: 74,284,238 (GRCm39) S649P possibly damaging Het
Rasgrf2 T C 13: 92,159,413 (GRCm39) M426V probably damaging Het
Rpl9 A G 5: 65,548,191 (GRCm39) I18T possibly damaging Het
Slc6a19 C A 13: 73,837,849 (GRCm39) E217* probably null Het
Smtn C A 11: 3,480,165 (GRCm39) R352L possibly damaging Het
Supv3l1 C A 10: 62,265,600 (GRCm39) D647Y probably damaging Het
Sv2a A G 3: 96,092,498 (GRCm39) Y66C probably damaging Het
Upk1b A G 16: 38,605,272 (GRCm39) I107T probably damaging Het
Yif1a T C 19: 5,139,813 (GRCm39) V86A possibly damaging Het
Zfp820 T C 17: 22,038,801 (GRCm39) T176A possibly damaging Het
Other mutations in Foxk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00339:Foxk2 APN 11 121,190,560 (GRCm39) missense probably damaging 1.00
IGL00502:Foxk2 APN 11 121,187,925 (GRCm39) splice site probably benign
IGL02619:Foxk2 APN 11 121,190,402 (GRCm39) splice site probably benign
R1843:Foxk2 UTSW 11 121,176,363 (GRCm39) missense probably benign 0.01
R2153:Foxk2 UTSW 11 121,151,213 (GRCm39) missense probably benign 0.08
R2847:Foxk2 UTSW 11 121,151,317 (GRCm39) small insertion probably benign
R3770:Foxk2 UTSW 11 121,151,317 (GRCm39) small insertion probably benign
R4024:Foxk2 UTSW 11 121,176,439 (GRCm39) missense possibly damaging 0.67
R6958:Foxk2 UTSW 11 121,190,563 (GRCm39) missense probably benign 0.16
R6968:Foxk2 UTSW 11 121,151,308 (GRCm39) missense possibly damaging 0.87
R7558:Foxk2 UTSW 11 121,178,884 (GRCm39) missense probably benign 0.00
R7736:Foxk2 UTSW 11 121,190,473 (GRCm39) missense possibly damaging 0.92
R7902:Foxk2 UTSW 11 121,190,553 (GRCm39) missense probably benign
Posted On 2016-08-02