Incidental Mutation 'IGL03068:Tlr11'
ID 409776
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tlr11
Ensembl Gene ENSMUSG00000051969
Gene Name toll-like receptor 11
Synonyms LOC239081
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03068
Quality Score
Status
Chromosome 14
Chromosomal Location 50595371-50601120 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50598941 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 309 (E309G)
Ref Sequence ENSEMBL: ENSMUSP00000138814 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063570] [ENSMUST00000185091]
AlphaFold Q6R5P0
Predicted Effect probably benign
Transcript: ENSMUST00000063570
AA Change: E304G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000068906
Gene: ENSMUSG00000051969
AA Change: E304G

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
low complexity region 105 122 N/A INTRINSIC
low complexity region 153 161 N/A INTRINSIC
LRR 311 333 3.36e1 SMART
LRR 335 361 4.44e0 SMART
LRR 362 383 2.03e1 SMART
LRR_TYP 384 407 2.57e-3 SMART
LRR_TYP 408 431 2.75e-3 SMART
low complexity region 544 556 N/A INTRINSIC
LRR 605 628 6.06e1 SMART
transmembrane domain 719 741 N/A INTRINSIC
Pfam:TIR 773 922 2.1e-9 PFAM
Pfam:TIR_2 776 894 6.6e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185091
AA Change: E309G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000138814
Gene: ENSMUSG00000051969
AA Change: E309G

DomainStartEndE-ValueType
transmembrane domain 16 38 N/A INTRINSIC
low complexity region 110 127 N/A INTRINSIC
low complexity region 158 166 N/A INTRINSIC
Pfam:LRR_6 221 244 5.3e-2 PFAM
LRR 316 338 3.36e1 SMART
LRR 340 366 4.44e0 SMART
LRR 367 388 2.03e1 SMART
LRR_TYP 389 412 2.57e-3 SMART
LRR_TYP 413 436 2.75e-3 SMART
low complexity region 549 561 N/A INTRINSIC
LRR 610 633 6.06e1 SMART
transmembrane domain 724 746 N/A INTRINSIC
Pfam:TIR_2 781 898 1e-12 PFAM
Pfam:TIR 781 922 1.8e-13 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ago3 A G 4: 126,311,171 (GRCm39) L14P probably damaging Het
Ak2 G T 4: 128,901,819 (GRCm39) probably benign Het
Appbp2 T C 11: 85,092,246 (GRCm39) Y311C probably damaging Het
Arl9 C A 5: 77,155,225 (GRCm39) L119I possibly damaging Het
Atp1a1 T C 3: 101,491,175 (GRCm39) H620R probably benign Het
Cfap52 T C 11: 67,826,682 (GRCm39) D381G probably benign Het
Cngb3 T C 4: 19,375,246 (GRCm39) F292S possibly damaging Het
Comtd1 G A 14: 21,897,711 (GRCm39) R203C probably damaging Het
Crmp1 G T 5: 37,422,633 (GRCm39) A147S possibly damaging Het
Csmd3 T A 15: 47,710,517 (GRCm39) H1586L possibly damaging Het
Ctnna1 G A 18: 35,382,785 (GRCm39) E644K possibly damaging Het
Dock3 T C 9: 106,841,958 (GRCm39) D957G possibly damaging Het
Ear1 G T 14: 44,056,502 (GRCm39) S122* probably null Het
Eefsec G T 6: 88,235,209 (GRCm39) Q576K probably benign Het
Efcab5 T A 11: 76,994,927 (GRCm39) I1215L probably benign Het
Etfa A T 9: 55,394,766 (GRCm39) D160E probably benign Het
Exoc7 G A 11: 116,191,960 (GRCm39) R197C possibly damaging Het
G6pc1 A G 11: 101,261,576 (GRCm39) D92G probably benign Het
Gm3182 T A 14: 4,483,921 (GRCm38) probably null Het
Gm4952 A G 19: 12,601,068 (GRCm39) N96S probably damaging Het
Gpr156 G A 16: 37,812,491 (GRCm39) V276M probably damaging Het
Irs2 A G 8: 11,054,974 (GRCm39) S1153P probably damaging Het
Kif21b T C 1: 136,086,093 (GRCm39) probably benign Het
Lmo7 A T 14: 102,112,928 (GRCm39) probably benign Het
Mapk4 G T 18: 74,103,415 (GRCm39) N31K probably damaging Het
Mccc2 T C 13: 100,100,319 (GRCm39) T357A probably damaging Het
Mpeg1 A G 19: 12,439,570 (GRCm39) T343A probably benign Het
Myo3b G T 2: 70,257,160 (GRCm39) probably benign Het
Pald1 T C 10: 61,156,963 (GRCm39) E829G possibly damaging Het
Pde11a A G 2: 75,848,208 (GRCm39) I873T probably damaging Het
Samd9l T A 6: 3,375,348 (GRCm39) K638* probably null Het
Sema4d A G 13: 51,862,922 (GRCm39) S479P probably damaging Het
Slc12a2 T C 18: 58,037,407 (GRCm39) probably benign Het
Slc47a2 T C 11: 61,194,769 (GRCm39) N470S probably damaging Het
Spag17 C T 3: 99,987,521 (GRCm39) P1604S probably benign Het
Taf8 C A 17: 47,812,290 (GRCm39) V39L probably damaging Het
Tmem260 A G 14: 48,724,371 (GRCm39) probably benign Het
Tsc1 A T 2: 28,571,270 (GRCm39) K816M probably damaging Het
Ttc29 A G 8: 79,052,180 (GRCm39) I354V probably benign Het
Ttll3 A T 6: 113,386,158 (GRCm39) N665Y probably damaging Het
Ubr4 A G 4: 139,137,041 (GRCm39) T971A probably benign Het
Vmn2r96 T A 17: 18,803,137 (GRCm39) I349N probably benign Het
Vwa5a A G 9: 38,646,143 (GRCm39) T504A probably benign Het
Ythdf3 T A 3: 16,258,882 (GRCm39) V354E possibly damaging Het
Zan C A 5: 137,474,677 (GRCm39) G13V probably damaging Het
Other mutations in Tlr11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00590:Tlr11 APN 14 50,598,373 (GRCm39) missense probably benign
IGL02090:Tlr11 APN 14 50,600,489 (GRCm39) missense probably damaging 0.99
IGL02286:Tlr11 APN 14 50,598,328 (GRCm39) missense possibly damaging 0.91
IGL02671:Tlr11 APN 14 50,598,149 (GRCm39) missense probably damaging 1.00
IGL03064:Tlr11 APN 14 50,598,557 (GRCm39) missense probably damaging 1.00
R0099:Tlr11 UTSW 14 50,598,275 (GRCm39) missense probably benign 0.14
R0727:Tlr11 UTSW 14 50,598,926 (GRCm39) missense possibly damaging 0.67
R0944:Tlr11 UTSW 14 50,599,793 (GRCm39) missense probably benign 0.12
R1490:Tlr11 UTSW 14 50,600,633 (GRCm39) missense probably benign 0.00
R1726:Tlr11 UTSW 14 50,598,998 (GRCm39) missense probably benign 0.00
R1803:Tlr11 UTSW 14 50,598,104 (GRCm39) missense probably benign 0.00
R1908:Tlr11 UTSW 14 50,598,664 (GRCm39) missense probably benign 0.00
R1971:Tlr11 UTSW 14 50,598,691 (GRCm39) missense probably benign
R1981:Tlr11 UTSW 14 50,599,445 (GRCm39) missense possibly damaging 0.95
R2023:Tlr11 UTSW 14 50,600,026 (GRCm39) missense probably damaging 0.96
R2079:Tlr11 UTSW 14 50,598,437 (GRCm39) missense probably damaging 0.99
R2155:Tlr11 UTSW 14 50,598,139 (GRCm39) missense probably benign 0.01
R2251:Tlr11 UTSW 14 50,598,249 (GRCm39) missense probably benign 0.02
R3017:Tlr11 UTSW 14 50,600,178 (GRCm39) nonsense probably null
R3760:Tlr11 UTSW 14 50,599,700 (GRCm39) missense probably damaging 1.00
R3876:Tlr11 UTSW 14 50,600,611 (GRCm39) missense probably benign
R3936:Tlr11 UTSW 14 50,600,192 (GRCm39) missense possibly damaging 0.78
R4002:Tlr11 UTSW 14 50,599,984 (GRCm39) missense probably benign
R4024:Tlr11 UTSW 14 50,600,303 (GRCm39) missense probably benign 0.02
R4118:Tlr11 UTSW 14 50,600,684 (GRCm39) missense probably damaging 1.00
R4222:Tlr11 UTSW 14 50,599,306 (GRCm39) missense probably damaging 0.99
R4365:Tlr11 UTSW 14 50,598,926 (GRCm39) missense probably damaging 0.98
R4678:Tlr11 UTSW 14 50,598,439 (GRCm39) missense possibly damaging 0.85
R4779:Tlr11 UTSW 14 50,598,707 (GRCm39) missense possibly damaging 0.76
R4910:Tlr11 UTSW 14 50,600,346 (GRCm39) missense probably benign 0.45
R4921:Tlr11 UTSW 14 50,600,342 (GRCm39) missense possibly damaging 0.48
R5114:Tlr11 UTSW 14 50,600,578 (GRCm39) missense possibly damaging 0.81
R5126:Tlr11 UTSW 14 50,598,287 (GRCm39) missense probably damaging 1.00
R5349:Tlr11 UTSW 14 50,598,337 (GRCm39) missense probably benign 0.45
R5606:Tlr11 UTSW 14 50,599,717 (GRCm39) missense probably benign 0.08
R5650:Tlr11 UTSW 14 50,598,658 (GRCm39) missense probably benign 0.03
R5958:Tlr11 UTSW 14 50,598,234 (GRCm39) missense probably damaging 0.99
R5966:Tlr11 UTSW 14 50,599,712 (GRCm39) missense probably benign 0.02
R6480:Tlr11 UTSW 14 50,600,512 (GRCm39) missense possibly damaging 0.62
R6484:Tlr11 UTSW 14 50,600,135 (GRCm39) missense probably damaging 0.99
R6679:Tlr11 UTSW 14 50,600,311 (GRCm39) missense probably benign 0.00
R6717:Tlr11 UTSW 14 50,599,561 (GRCm39) missense probably benign
R7085:Tlr11 UTSW 14 50,600,113 (GRCm39) missense probably damaging 0.99
R7241:Tlr11 UTSW 14 50,599,598 (GRCm39) missense possibly damaging 0.95
R7440:Tlr11 UTSW 14 50,598,801 (GRCm39) missense probably benign 0.00
R7482:Tlr11 UTSW 14 50,600,456 (GRCm39) missense probably damaging 0.99
R7582:Tlr11 UTSW 14 50,599,186 (GRCm39) nonsense probably null
R7790:Tlr11 UTSW 14 50,599,382 (GRCm39) missense probably benign
R7818:Tlr11 UTSW 14 50,599,285 (GRCm39) missense probably damaging 1.00
R7827:Tlr11 UTSW 14 50,598,611 (GRCm39) missense probably benign 0.00
R8144:Tlr11 UTSW 14 50,599,945 (GRCm39) missense probably damaging 0.99
R8847:Tlr11 UTSW 14 50,600,182 (GRCm39) missense possibly damaging 0.85
R9027:Tlr11 UTSW 14 50,598,749 (GRCm39) missense probably damaging 1.00
R9035:Tlr11 UTSW 14 50,598,434 (GRCm39) missense probably benign 0.00
R9393:Tlr11 UTSW 14 50,599,547 (GRCm39) missense probably benign 0.03
RF002:Tlr11 UTSW 14 50,598,682 (GRCm39) missense possibly damaging 0.63
Z1088:Tlr11 UTSW 14 50,599,795 (GRCm39) missense possibly damaging 0.48
Z1176:Tlr11 UTSW 14 50,599,793 (GRCm39) missense probably benign 0.40
Z1176:Tlr11 UTSW 14 50,598,119 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02