Incidental Mutation 'IGL03069:Ttc24'
ID 409821
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ttc24
Ensembl Gene ENSMUSG00000051036
Gene Name tetratricopeptide repeat domain 24
Synonyms A430025D11Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # IGL03069
Quality Score
Status
Chromosome 3
Chromosomal Location 87976717-87985611 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87977408 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 113 (T113S)
Ref Sequence ENSEMBL: ENSMUSP00000066531 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050258] [ENSMUST00000064550]
AlphaFold Q8BYG0
Predicted Effect probably benign
Transcript: ENSMUST00000050258
AA Change: T311S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000061571
Gene: ENSMUSG00000051036
AA Change: T311S

DomainStartEndE-ValueType
TPR 35 68 3.5e0 SMART
TPR 72 105 4.09e-1 SMART
TPR 112 145 3.41e1 SMART
TPR 152 185 6.95e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000064550
AA Change: T113S

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029H14Rik T G 8: 13,607,704 (GRCm39) probably null Het
Acp3 T C 9: 104,197,204 (GRCm39) E145G possibly damaging Het
Ankrd28 T A 14: 31,477,743 (GRCm39) K42* probably null Het
Arsg A T 11: 109,454,082 (GRCm39) K429N probably damaging Het
Bsn G A 9: 107,991,462 (GRCm39) T1430I probably damaging Het
Calu A G 6: 29,356,582 (GRCm39) D36G possibly damaging Het
Ccdc18 T C 5: 108,376,767 (GRCm39) S1403P probably damaging Het
Cdca2 A G 14: 67,952,385 (GRCm39) probably benign Het
Cfh C A 1: 140,026,793 (GRCm39) probably benign Het
Cyp2c69 C T 19: 39,869,537 (GRCm39) G161S probably benign Het
Dennd4c C A 4: 86,692,674 (GRCm39) Y61* probably null Het
Diaph3 A G 14: 87,009,555 (GRCm39) S1075P probably damaging Het
Dpp7 T A 2: 25,245,735 (GRCm39) probably null Het
Dtd1 T A 2: 144,588,981 (GRCm39) probably benign Het
Dtl C A 1: 191,289,008 (GRCm39) probably benign Het
Exoc3l4 A G 12: 111,390,457 (GRCm39) D344G probably damaging Het
Hsp90ab1 A T 17: 45,879,954 (GRCm39) C159S possibly damaging Het
Kcnip2 T C 19: 45,784,710 (GRCm39) probably benign Het
Krba1 A G 6: 48,391,483 (GRCm39) T755A possibly damaging Het
L2hgdh C T 12: 69,739,173 (GRCm39) V433I probably benign Het
Lamc1 A T 1: 153,115,127 (GRCm39) L1050I probably damaging Het
Lgals4 A T 7: 28,540,343 (GRCm39) I213L probably benign Het
Lysmd1 A G 3: 95,044,945 (GRCm39) I64V probably damaging Het
Mfsd4b4 A C 10: 39,768,311 (GRCm39) C261G probably benign Het
Mrgprb3 T A 7: 48,293,198 (GRCm39) I118F possibly damaging Het
Mtmr2 T A 9: 13,704,501 (GRCm39) Y137* probably null Het
Ofcc1 A T 13: 40,226,140 (GRCm39) H797Q probably benign Het
Omd A T 13: 49,745,870 (GRCm39) probably benign Het
Or5d46 C T 2: 88,170,643 (GRCm39) probably null Het
Or8g21 A T 9: 38,906,728 (GRCm39) M1K probably null Het
Polr3a T A 14: 24,511,808 (GRCm39) D916V probably damaging Het
Prpf38a T C 4: 108,432,628 (GRCm39) Y117C probably damaging Het
Scn11a C T 9: 119,619,029 (GRCm39) G771D probably benign Het
Smarca4 C T 9: 21,547,132 (GRCm39) T219I probably benign Het
Snx1 T A 9: 66,001,906 (GRCm39) I306F probably benign Het
Snx31 T A 15: 36,525,749 (GRCm39) R317* probably null Het
Sorl1 T C 9: 41,902,722 (GRCm39) T1612A probably benign Het
Spag1 G T 15: 36,224,245 (GRCm39) probably benign Het
Stambp A G 6: 83,538,914 (GRCm39) F162S probably damaging Het
Tkfc T A 19: 10,576,518 (GRCm39) M122L probably benign Het
Tnni3k T A 3: 154,647,242 (GRCm39) probably null Het
Trim56 T C 5: 137,142,616 (GRCm39) Q300R probably damaging Het
Xirp2 A T 2: 67,339,876 (GRCm39) T706S possibly damaging Het
Yipf5 T A 18: 40,339,290 (GRCm39) probably benign Het
Zfp202 T C 9: 40,122,695 (GRCm39) S486P probably damaging Het
Zfp407 A G 18: 84,369,100 (GRCm39) S1676P probably damaging Het
Znrd2 G T 19: 5,780,450 (GRCm39) L183I possibly damaging Het
Other mutations in Ttc24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01896:Ttc24 APN 3 87,977,720 (GRCm39) critical splice acceptor site probably null
R0153:Ttc24 UTSW 3 87,982,234 (GRCm39) unclassified probably benign
R1626:Ttc24 UTSW 3 87,977,366 (GRCm39) missense probably benign 0.00
R1735:Ttc24 UTSW 3 87,980,401 (GRCm39) splice site probably null
R1938:Ttc24 UTSW 3 87,982,181 (GRCm39) missense probably benign 0.28
R4112:Ttc24 UTSW 3 87,981,946 (GRCm39) missense probably damaging 0.99
R4200:Ttc24 UTSW 3 87,981,824 (GRCm39) missense probably benign 0.01
R7600:Ttc24 UTSW 3 87,979,320 (GRCm39) start codon destroyed probably null
R7939:Ttc24 UTSW 3 87,981,945 (GRCm39) missense possibly damaging 0.83
R8432:Ttc24 UTSW 3 87,977,366 (GRCm39) missense probably benign 0.15
R8519:Ttc24 UTSW 3 87,980,369 (GRCm39) missense probably damaging 1.00
R8784:Ttc24 UTSW 3 87,980,033 (GRCm39) nonsense probably null
R9164:Ttc24 UTSW 3 87,980,295 (GRCm39) nonsense probably null
R9370:Ttc24 UTSW 3 87,980,136 (GRCm39) missense probably benign 0.20
R9531:Ttc24 UTSW 3 87,978,416 (GRCm39) missense possibly damaging 0.79
Z1176:Ttc24 UTSW 3 87,979,293 (GRCm39) missense probably benign 0.06
Z1176:Ttc24 UTSW 3 87,978,365 (GRCm39) frame shift probably null
Posted On 2016-08-02