Incidental Mutation 'IGL03121:Stk3'
ID 409991
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Stk3
Ensembl Gene ENSMUSG00000022329
Gene Name serine/threonine kinase 3
Synonyms Ste20, 0610042I06Rik, Mst2, MST, mess1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03121
Quality Score
Status
Chromosome 15
Chromosomal Location 34875645-35155990 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 35099572 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000154154 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018476] [ENSMUST00000067033] [ENSMUST00000138841] [ENSMUST00000226555]
AlphaFold Q9JI10
Predicted Effect probably benign
Transcript: ENSMUST00000018476
SMART Domains Protein: ENSMUSP00000018476
Gene: ENSMUSG00000022329

DomainStartEndE-ValueType
low complexity region 7 19 N/A INTRINSIC
S_TKc 27 278 4.16e-103 SMART
low complexity region 301 324 N/A INTRINSIC
low complexity region 370 381 N/A INTRINSIC
Pfam:Mst1_SARAH 443 490 9.6e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000067033
SMART Domains Protein: ENSMUSP00000064225
Gene: ENSMUSG00000022329

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 5 205 2.1e-41 PFAM
Pfam:Pkinase 5 208 1.2e-56 PFAM
coiled coil region 217 256 N/A INTRINSIC
low complexity region 300 311 N/A INTRINSIC
Pfam:Mst1_SARAH 372 420 9.8e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138841
Predicted Effect probably benign
Transcript: ENSMUST00000226555
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
PHENOTYPE: Homozygous inactivation of this gene generally results in mice that are viable, fertile and developmentally normal. A small subset of mice homozygous for a knock-out allele develop mammary tumors in the absence of immunological defects. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012B09Rik A G 9: 14,672,946 (GRCm39) S4P possibly damaging Het
A2m A G 6: 121,618,265 (GRCm39) N186S probably benign Het
Afg2a T C 3: 37,518,800 (GRCm39) I778T probably damaging Het
Ago1 T C 4: 126,353,796 (GRCm39) K261R probably benign Het
Alas1 G A 9: 106,124,113 (GRCm39) P15L probably damaging Het
Aox1 G A 1: 58,398,113 (GRCm39) V1285M probably damaging Het
Brd8 A T 18: 34,739,740 (GRCm39) F678I probably damaging Het
Col27a1 T A 4: 63,143,446 (GRCm39) M378K probably benign Het
Dpy19l4 C A 4: 11,303,334 (GRCm39) V196F probably damaging Het
Dst G T 1: 34,256,884 (GRCm39) probably benign Het
Hsd17b1 T A 11: 100,970,870 (GRCm39) Y275* probably null Het
Kdm3b A G 18: 34,928,762 (GRCm39) E171G probably damaging Het
Klc1 T C 12: 111,748,076 (GRCm39) probably benign Het
Mlkl G A 8: 112,041,612 (GRCm39) R443W probably damaging Het
Mov10 A T 3: 104,708,318 (GRCm39) V477E probably benign Het
Nacad A G 11: 6,550,933 (GRCm39) S753P probably damaging Het
Ncapd2 A C 6: 125,150,575 (GRCm39) M842R probably benign Het
Nkd2 C A 13: 73,969,498 (GRCm39) A311S probably benign Het
Nrg1 A G 8: 32,314,608 (GRCm39) probably benign Het
Or4f6 A G 2: 111,838,953 (GRCm39) Y193H probably benign Het
Or6c68 A G 10: 129,158,037 (GRCm39) I182V probably benign Het
Pde6h A G 6: 136,936,280 (GRCm39) S8G probably null Het
Pik3c2b A G 1: 133,007,483 (GRCm39) K616E probably benign Het
Pnpt1 A T 11: 29,082,845 (GRCm39) R54S probably benign Het
Pramel38 T C 5: 94,368,912 (GRCm39) V469A possibly damaging Het
Rttn A G 18: 88,993,875 (GRCm39) D184G probably damaging Het
Skint5 T A 4: 113,574,284 (GRCm39) I756F unknown Het
Slc24a2 T C 4: 87,145,143 (GRCm39) T304A probably benign Het
Trim69 A G 2: 121,998,128 (GRCm39) I33M probably benign Het
Ube2q2 A T 9: 55,102,323 (GRCm39) probably benign Het
Vmn1r67 T A 7: 10,181,394 (GRCm39) N158K probably benign Het
Wipi2 G A 5: 142,648,857 (GRCm39) E252K probably benign Het
Other mutations in Stk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Stk3 APN 15 35,114,768 (GRCm39) missense possibly damaging 0.93
IGL02133:Stk3 APN 15 35,099,662 (GRCm39) missense probably damaging 1.00
IGL03309:Stk3 APN 15 35,099,697 (GRCm39) splice site probably benign
R0276:Stk3 UTSW 15 35,099,615 (GRCm39) missense probably damaging 1.00
R0416:Stk3 UTSW 15 35,114,778 (GRCm39) missense probably benign 0.07
R1352:Stk3 UTSW 15 35,008,371 (GRCm39) missense probably damaging 1.00
R1633:Stk3 UTSW 15 34,959,206 (GRCm39) missense probably damaging 1.00
R1638:Stk3 UTSW 15 35,008,454 (GRCm39) splice site probably null
R1917:Stk3 UTSW 15 35,073,363 (GRCm39) missense probably damaging 1.00
R1919:Stk3 UTSW 15 35,073,363 (GRCm39) missense probably damaging 1.00
R2011:Stk3 UTSW 15 35,072,644 (GRCm39) missense probably damaging 1.00
R2072:Stk3 UTSW 15 34,959,195 (GRCm39) missense possibly damaging 0.79
R2073:Stk3 UTSW 15 34,959,195 (GRCm39) missense possibly damaging 0.79
R2075:Stk3 UTSW 15 34,959,195 (GRCm39) missense possibly damaging 0.79
R3158:Stk3 UTSW 15 35,008,387 (GRCm39) missense possibly damaging 0.83
R3402:Stk3 UTSW 15 34,945,144 (GRCm39) splice site probably benign
R4633:Stk3 UTSW 15 34,959,074 (GRCm39) missense probably damaging 0.99
R4672:Stk3 UTSW 15 35,099,603 (GRCm39) missense probably benign 0.06
R4687:Stk3 UTSW 15 35,114,711 (GRCm39) missense probably damaging 0.99
R4825:Stk3 UTSW 15 35,000,054 (GRCm39) missense probably benign 0.14
R4903:Stk3 UTSW 15 34,959,212 (GRCm39) missense probably damaging 0.99
R5390:Stk3 UTSW 15 35,114,706 (GRCm39) nonsense probably null
R5834:Stk3 UTSW 15 34,959,164 (GRCm39) missense probably damaging 1.00
R7208:Stk3 UTSW 15 35,073,262 (GRCm39) missense possibly damaging 0.76
R7266:Stk3 UTSW 15 34,959,182 (GRCm39) missense probably benign 0.05
R7862:Stk3 UTSW 15 35,115,732 (GRCm39) missense possibly damaging 0.90
R8354:Stk3 UTSW 15 34,876,870 (GRCm39) missense probably damaging 1.00
R8454:Stk3 UTSW 15 34,876,870 (GRCm39) missense probably damaging 1.00
R8996:Stk3 UTSW 15 34,945,208 (GRCm39) missense possibly damaging 0.51
R9160:Stk3 UTSW 15 35,099,611 (GRCm39) missense probably damaging 0.99
R9366:Stk3 UTSW 15 35,072,634 (GRCm39) missense probably damaging 1.00
R9777:Stk3 UTSW 15 35,114,791 (GRCm39) missense probably damaging 1.00
X0021:Stk3 UTSW 15 35,072,701 (GRCm39) missense probably damaging 1.00
X0060:Stk3 UTSW 15 35,114,679 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02