Incidental Mutation 'IGL03122:Or5ac15'
ID 410001
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or5ac15
Ensembl Gene ENSMUSG00000063020
Gene Name olfactory receptor family 5 subfamily AC member 15
Synonyms MOR182-13, MOR182-7P, GA_x54KRFPKG5P-55348161-55347241, Olfr194
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL03122
Quality Score
Status
Chromosome 16
Chromosomal Location 58939511-58940431 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58939801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 211 (M211V)
Ref Sequence ENSEMBL: ENSMUSP00000149379 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072608] [ENSMUST00000213228] [ENSMUST00000216519]
AlphaFold L7N1Y8
Predicted Effect probably benign
Transcript: ENSMUST00000072608
AA Change: M211V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000072407
Gene: ENSMUSG00000063020
AA Change: M211V

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 1.7e-47 PFAM
Pfam:7tm_1 40 289 1.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213228
AA Change: M211V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000216519
AA Change: M211V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg7 G A 16: 56,590,725 (GRCm39) probably benign Het
Afap1l1 T C 18: 61,866,902 (GRCm39) D719G probably benign Het
Amph C T 13: 19,287,113 (GRCm39) T274M probably damaging Het
Atp2c2 T A 8: 120,469,414 (GRCm39) D396E possibly damaging Het
Atpaf1 T C 4: 115,648,475 (GRCm39) I164T probably damaging Het
Avpr1b C A 1: 131,528,257 (GRCm39) P260Q probably damaging Het
Cacna1a T C 8: 85,189,305 (GRCm39) probably benign Het
Cald1 A G 6: 34,741,963 (GRCm39) I449V probably damaging Het
Ccdc24 A G 4: 117,728,942 (GRCm39) probably null Het
Cdcp3 A G 7: 130,798,243 (GRCm39) Q84R possibly damaging Het
Cenpk C A 13: 104,378,885 (GRCm39) Q134K probably damaging Het
Clasp1 A G 1: 118,438,007 (GRCm39) N373D probably damaging Het
Col7a1 T A 9: 108,790,751 (GRCm39) S1042T unknown Het
Cry2 G A 2: 92,243,640 (GRCm39) R439C probably damaging Het
Dip2a G T 10: 76,110,880 (GRCm39) D1138E probably benign Het
Dlgap3 T C 4: 127,089,018 (GRCm39) S205P possibly damaging Het
Echdc2 T A 4: 108,022,777 (GRCm39) S18T probably benign Het
Efcab2 T A 1: 178,265,042 (GRCm39) V36E probably damaging Het
Galk1 A T 11: 115,901,065 (GRCm39) probably null Het
Hoxc11 A T 15: 102,863,390 (GRCm39) N144Y probably damaging Het
Ift140 T A 17: 25,305,884 (GRCm39) C824S probably damaging Het
Inf2 A G 12: 112,570,663 (GRCm39) S401G probably benign Het
Kcnn1 T G 8: 71,307,724 (GRCm39) D106A probably damaging Het
Lama4 A G 10: 38,943,959 (GRCm39) N754S probably benign Het
Marchf6 A G 15: 31,478,439 (GRCm39) probably null Het
Nlrp1b A C 11: 71,072,659 (GRCm39) C395G probably benign Het
Or2n1d T C 17: 38,646,192 (GRCm39) V48A probably benign Het
Or4k2 A T 14: 50,424,461 (GRCm39) M71K probably damaging Het
Or9q1 A G 19: 13,805,014 (GRCm39) S249P possibly damaging Het
Scel A G 14: 103,836,842 (GRCm39) R477G possibly damaging Het
Sdk2 A G 11: 113,732,894 (GRCm39) S984P probably damaging Het
Slc4a7 C T 14: 14,782,040 (GRCm38) probably benign Het
Tas2r103 A G 6: 133,013,872 (GRCm39) S65P probably damaging Het
Tnip2 T C 5: 34,661,095 (GRCm39) E119G possibly damaging Het
Zgrf1 T A 3: 127,381,782 (GRCm39) L310M possibly damaging Het
Other mutations in Or5ac15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01807:Or5ac15 APN 16 58,939,936 (GRCm39) missense possibly damaging 0.94
IGL02098:Or5ac15 APN 16 58,940,433 (GRCm39) utr 5 prime probably benign
IGL02276:Or5ac15 APN 16 58,940,378 (GRCm39) missense probably benign 0.01
R0781:Or5ac15 UTSW 16 58,940,187 (GRCm39) missense probably damaging 0.97
R1162:Or5ac15 UTSW 16 58,939,735 (GRCm39) missense probably damaging 0.99
R1526:Or5ac15 UTSW 16 58,940,293 (GRCm39) missense probably damaging 1.00
R1654:Or5ac15 UTSW 16 58,940,052 (GRCm39) missense possibly damaging 0.50
R4379:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R4380:Or5ac15 UTSW 16 58,940,027 (GRCm39) missense probably benign 0.22
R5768:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5771:Or5ac15 UTSW 16 58,940,335 (GRCm39) small deletion probably benign
R5942:Or5ac15 UTSW 16 58,940,039 (GRCm39) nonsense probably null
R6131:Or5ac15 UTSW 16 58,940,256 (GRCm39) missense probably damaging 1.00
R6539:Or5ac15 UTSW 16 58,940,114 (GRCm39) missense probably damaging 0.99
R6621:Or5ac15 UTSW 16 58,940,287 (GRCm39) missense probably benign 0.19
R7642:Or5ac15 UTSW 16 58,940,011 (GRCm39) missense possibly damaging 0.94
R8308:Or5ac15 UTSW 16 58,939,899 (GRCm39) missense probably damaging 1.00
R8863:Or5ac15 UTSW 16 58,939,712 (GRCm39) nonsense probably null
RF009:Or5ac15 UTSW 16 58,940,274 (GRCm39) missense probably damaging 0.99
Z1177:Or5ac15 UTSW 16 58,939,735 (GRCm39) nonsense probably null
Posted On 2016-08-02