Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03123:Zfp526'

410063

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp526

Ensembl Gene

ENSMUSG00000046541

Gene Name

zinc finger protein 526

Synonyms

D030024H03Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.160) question?

Stock #

IGL03123

Quality Score

Status

Chromosome

Chromosomal Location

24920850-24926932 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 24924049 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 103 (T103P)

Ref Sequence

ENSEMBL: ENSMUSP00000053567 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055604] [ENSMUST00000058702] [ENSMUST00000071739] [ENSMUST00000108411] [ENSMUST00000205271]

AlphaFold

Q8BI66

Predicted Effect

probably benign
Transcript: ENSMUST00000055604
AA Change: T103P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000053567
Gene: ENSMUSG00000046541
AA Change: T103P

Domain	Start	End	E-Value	Type
ZnF_C2H2	56	78	1.41e0	SMART
low complexity region	79	90	N/A	INTRINSIC
ZnF_C2H2	108	130	9.46e0	SMART
ZnF_C2H2	140	163	4.65e-1	SMART
low complexity region	171	193	N/A	INTRINSIC
ZnF_C2H2	200	222	4.72e-2	SMART
coiled coil region	234	254	N/A	INTRINSIC
ZnF_C2H2	280	303	1.26e1	SMART
ZnF_C2H2	312	334	3.29e-1	SMART
ZnF_C2H2	339	361	6.78e-3	SMART
ZnF_C2H2	367	389	4.65e-1	SMART
ZnF_C2H2	395	416	3.56e1	SMART
ZnF_C2H2	447	470	8.47e-4	SMART
ZnF_C2H2	477	499	2.05e-2	SMART
ZnF_C2H2	505	527	2.09e-3	SMART
ZnF_C2H2	533	555	5.99e-4	SMART
ZnF_C2H2	578	600	8.22e-2	SMART
low complexity region	610	624	N/A	INTRINSIC
low complexity region	656	670	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000058702

SMART Domains

Protein: ENSMUSP00000049763
Gene: ENSMUSG00000054499

Domain	Start	End	E-Value	Type
DED	24	104	6.34e-13	SMART
low complexity region	130	147	N/A	INTRINSIC
low complexity region	157	182	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000071739

SMART Domains

Protein: ENSMUSP00000071654
Gene: ENSMUSG00000057177

Domain	Start	End	E-Value	Type
low complexity region	2	15	N/A	INTRINSIC
low complexity region	25	90	N/A	INTRINSIC
S_TKc	119	404	3.11e-84	SMART
low complexity region	481	490	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108411

SMART Domains

Protein: ENSMUSP00000104049
Gene: ENSMUSG00000057177

Domain	Start	End	E-Value	Type
low complexity region	2	15	N/A	INTRINSIC
low complexity region	25	90	N/A	INTRINSIC
S_TKc	119	404	3.11e-84	SMART
low complexity region	477	486	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000169914

SMART Domains

Protein: ENSMUSP00000126890
Gene: ENSMUSG00000090330

Domain	Start	End	E-Value	Type
low complexity region	77	90	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190693

Predicted Effect

probably benign
Transcript: ENSMUST00000205271

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206654

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206498

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206750

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206788

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap5m1	T	C	14: 49,311,218 (GRCm39)	V96A	probably damaging	Het
Atp10b	T	C	11: 43,044,110 (GRCm39)	V112A	probably benign	Het
Caprin2	G	T	6: 148,796,505 (GRCm39)	A36E	probably damaging	Het
Castor1	A	T	11: 4,170,278 (GRCm39)	T119S	probably damaging	Het
Dnase1l2	T	C	17: 24,661,226 (GRCm39)	M28V	possibly damaging	Het
Eci1	T	A	17: 24,655,300 (GRCm39)		probably null	Het
Edil3	T	A	13: 89,279,855 (GRCm39)	S178T	probably damaging	Het
Epha5	A	G	5: 84,479,085 (GRCm39)		probably null	Het
Exoc3l4	A	G	12: 111,388,547 (GRCm39)	E12G	probably damaging	Het
Frmd7	G	A	X: 49,984,835 (GRCm39)	T445I	probably benign	Het
Golga4	A	G	9: 118,365,953 (GRCm39)	E344G	probably damaging	Het
H2-M10.4	A	G	17: 36,772,812 (GRCm39)	Y57H	probably damaging	Het
Hnmt	T	C	2: 23,909,171 (GRCm39)	I81V	probably benign	Het
Hsd17b7	C	T	1: 169,780,649 (GRCm39)	E320K	probably damaging	Het
Htra3	C	T	5: 35,823,477 (GRCm39)	V280I	probably damaging	Het
Impg2	G	T	16: 56,087,485 (GRCm39)	E992D	probably damaging	Het
Kctd4	T	C	14: 76,200,418 (GRCm39)	W130R	possibly damaging	Het
Kdm3b	T	A	18: 34,942,544 (GRCm39)		probably null	Het
Kmt2d	G	A	15: 98,759,652 (GRCm39)	T1202M	unknown	Het
Lrp11	A	T	10: 7,478,689 (GRCm39)	D326V	probably damaging	Het
Lrrcc1	A	T	3: 14,601,144 (GRCm39)	I59F	probably damaging	Het
Lyg2	G	A	1: 37,954,845 (GRCm39)		probably benign	Het
Med16	A	G	10: 79,732,667 (GRCm39)	V699A	probably damaging	Het
Myo18b	G	T	5: 113,022,804 (GRCm39)		probably benign	Het
Nrxn2	A	G	19: 6,531,767 (GRCm39)	T744A	probably damaging	Het
Or1e1f	T	A	11: 73,855,812 (GRCm39)	I126N	probably damaging	Het
Oser1	A	T	2: 163,253,309 (GRCm39)		probably benign	Het
Pcdhgc5	T	C	18: 37,952,966 (GRCm39)	V80A	probably benign	Het
Pi4ka	C	T	16: 17,100,539 (GRCm39)	G1857D	possibly damaging	Het
Pitpnc1	C	T	11: 107,228,237 (GRCm39)		probably null	Het
Pofut2	A	G	10: 77,102,844 (GRCm39)	E137G	probably benign	Het
Rgsl1	A	T	1: 153,701,687 (GRCm39)	W291R	probably damaging	Het
Rnf113a2	T	C	12: 84,465,050 (GRCm39)	I314T	probably benign	Het
Rps2	C	T	17: 24,939,263 (GRCm39)		probably benign	Het
Setbp1	T	C	18: 78,900,224 (GRCm39)	K1148E	probably damaging	Het
Slc45a2	A	G	15: 11,012,741 (GRCm39)	D248G	probably benign	Het
Slit2	G	T	5: 48,368,681 (GRCm39)	R352L	probably damaging	Het
Smg1	A	G	7: 117,756,404 (GRCm39)		probably benign	Het
Sycp2	A	T	2: 177,994,272 (GRCm39)	C1217*	probably null	Het
Tbcb	A	G	7: 29,926,261 (GRCm39)		probably benign	Het
Tinf2	T	C	14: 55,918,346 (GRCm39)	D128G	probably damaging	Het
Traf3ip2	A	G	10: 39,515,218 (GRCm39)	D332G	possibly damaging	Het
Tram1	A	G	1: 13,659,829 (GRCm39)	F40L	probably benign	Het
Trank1	A	T	9: 111,196,475 (GRCm39)	I1500L	probably damaging	Het
Wdfy4	G	A	14: 32,884,827 (GRCm39)	P25L	probably benign	Het
Wnt5a	G	T	14: 28,244,882 (GRCm39)	Q376H	probably damaging	Het

Other mutations in Zfp526

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02255:Zfp526	APN	7	24,924,958 (GRCm39)	missense	possibly damaging	0.89
IGL02983:Zfp526	APN	7	24,923,840 (GRCm39)	missense	probably benign	0.27
R0456:Zfp526	UTSW	7	24,925,637 (GRCm39)	missense	probably damaging	1.00
R1269:Zfp526	UTSW	7	24,923,788 (GRCm39)	missense	probably benign
R1542:Zfp526	UTSW	7	24,925,687 (GRCm39)	missense	probably benign	0.12
R1668:Zfp526	UTSW	7	24,924,967 (GRCm39)	missense	probably benign	0.15
R1742:Zfp526	UTSW	7	24,923,939 (GRCm39)	missense	possibly damaging	0.93
R1870:Zfp526	UTSW	7	24,924,594 (GRCm39)	missense	possibly damaging	0.67
R3791:Zfp526	UTSW	7	24,925,628 (GRCm39)	missense	probably damaging	0.98
R4755:Zfp526	UTSW	7	24,925,064 (GRCm39)	missense	probably benign	0.00
R4833:Zfp526	UTSW	7	24,925,295 (GRCm39)	missense	probably damaging	1.00
R5549:Zfp526	UTSW	7	24,925,109 (GRCm39)	missense	possibly damaging	0.82
R5853:Zfp526	UTSW	7	24,924,601 (GRCm39)	nonsense	probably null
R6061:Zfp526	UTSW	7	24,925,757 (GRCm39)	missense	probably damaging	1.00
R6186:Zfp526	UTSW	7	24,925,561 (GRCm39)	missense	probably benign
R7270:Zfp526	UTSW	7	24,925,345 (GRCm39)	missense	probably damaging	1.00
R7882:Zfp526	UTSW	7	24,920,860 (GRCm39)	unclassified	probably benign
R8084:Zfp526	UTSW	7	24,924,737 (GRCm39)	missense	probably damaging	0.99
R9016:Zfp526	UTSW	7	24,925,264 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02