Incidental Mutation 'IGL03127:Gcnt7'
ID410198
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gcnt7
Ensembl Gene ENSMUSG00000074569
Gene Nameglucosaminyl (N-acetyl) transferase family member 7
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.121) question?
Stock #IGL03127
Quality Score
Status
Chromosome2
Chromosomal Location172450313-172458596 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 172454411 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 110 (C110*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029005] [ENSMUST00000099060]
Predicted Effect probably benign
Transcript: ENSMUST00000029005
SMART Domains Protein: ENSMUSP00000029005
Gene: ENSMUSG00000027502

DomainStartEndE-ValueType
Pfam:Rtf2 1 290 1.5e-99 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000099060
AA Change: C164*
SMART Domains Protein: ENSMUSP00000096659
Gene: ENSMUSG00000074569
AA Change: C164*

DomainStartEndE-ValueType
low complexity region 31 40 N/A INTRINSIC
Pfam:Branch 115 377 5.8e-40 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000109132
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140048
Predicted Effect probably null
Transcript: ENSMUST00000161334
AA Change: C110*
SMART Domains Protein: ENSMUSP00000125368
Gene: ENSMUSG00000074569
AA Change: C110*

DomainStartEndE-ValueType
Pfam:Branch 62 285 1.7e-38 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1b A G 15: 101,203,078 R374G probably damaging Het
Amdhd2 A G 17: 24,157,738 probably null Het
Apol7c A G 15: 77,525,906 M280T probably benign Het
Atl2 T C 17: 79,852,854 M264V probably damaging Het
Ccdc141 C T 2: 77,029,235 probably null Het
Dtx4 T C 19: 12,486,500 probably benign Het
Dyrk4 G A 6: 126,897,171 T152I possibly damaging Het
F5 T A 1: 164,193,538 I1194N probably benign Het
Gadl1 C T 9: 115,948,664 T126M probably damaging Het
H2-M9 C T 17: 36,640,822 V254M possibly damaging Het
Hadha A T 5: 30,134,186 Het
Kit T C 5: 75,641,188 M621T probably benign Het
Krt73 T C 15: 101,795,840 M422V probably benign Het
Neil2 T C 14: 63,191,808 H12R probably benign Het
Nrsn1 A G 13: 25,253,717 L76P probably damaging Het
Olfr1393 T G 11: 49,280,772 V208G possibly damaging Het
Olfr906 C A 9: 38,488,586 Q186K probably benign Het
Olfr924 T A 9: 38,848,209 Y32N probably damaging Het
Pot1a G A 6: 25,794,616 A23V probably benign Het
Ppp1r14d A G 2: 119,218,360 *147Q probably null Het
Ptger2 T C 14: 45,002,005 probably benign Het
Syne3 A T 12: 104,943,428 D716E probably benign Het
Tbc1d9 A G 8: 83,249,473 N554D probably damaging Het
Ushbp1 T A 8: 71,394,376 Q204L possibly damaging Het
Other mutations in Gcnt7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01488:Gcnt7 APN 2 172454289 missense probably damaging 1.00
IGL03293:Gcnt7 APN 2 172454383 missense possibly damaging 0.73
R1781:Gcnt7 UTSW 2 172454880 missense probably benign 0.03
R6468:Gcnt7 UTSW 2 172454073 missense probably damaging 1.00
R6884:Gcnt7 UTSW 2 172454205 missense probably damaging 1.00
Posted On2016-08-02